Preterm infants with severe extrauterine growth retardation (EUGR) are at high risk of growth impairment during childhood

V. Pampanini, A. Boiani, C. De Marchis, C. Giacomozzi, R. Navas, R. Agostino, F. Dini, P. Ghirri, S. Cianfarani

Research output: Contribution to journalArticlepeer-review


Extrauterine growth retardation (EUGR) seriously affects premature newborns and is related to the impairment of growth during childhood. There are very limited data available concerning the growth outcome of EUGR children. Our aim was to assess the growth outcome in a cohort of children born before 34 weeks of gestation with severe EUGR. This was a retrospective multicenter study, performed in outpatient endocrinology clinic. A total of 103 premature children with weight and/or length below −2 standard deviation score (SDS) of “intrauterine” growth expectation at the time of discharge from hospital (within 42 weeks of postmenstrual age) were included in the study. The study participants underwent a thorough anthropometric assessment at a mean age of 3.9 years±1.7 SD. Of the EUGR children, 12.6 % showed a height below −2 SDS and 7.7 % even below−2.5 SDS. Growth impairment was more common in males than in females (17 vs. 8 %). The prevalence of subnormal weight (below −2 SDS) was 13.6 %, being higher in males than in females (17 vs. 10 %). BMI values below −2 SDS were found in 18.4 % of our study population (22.7 % in males and 12 % in females). The 19.6 % of EUGR children did not catch up in head circumference during early childhood. Length at term was the major predictor of height in childhood (P

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalEuropean Journal of Pediatrics
Issue number1
Publication statusPublished - Jun 24 2014


  • Extrauterine growth retardation
  • Growth
  • Low birth weight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


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