TY - JOUR
T1 - Preterm white matter injury
T2 - ultrasound diagnosis and classification
AU - eurUS.brain group
AU - Agut, Thais
AU - Alarcon, Ana
AU - Cabañas, Fernando
AU - Bartocci, Marco
AU - Martinez-Biarge, Miriam
AU - Horsch, Sandra
AU - Agut, Thais
AU - Alarcon, Ana
AU - Arena, Roberta
AU - Bartocci, Marco
AU - Bravo, Mayka
AU - Cabañas, Fernando
AU - Carreras, Nuria
AU - Claris, Olivier
AU - Dudink, Jeroen
AU - Fumagalli, Monica
AU - Govaert, Paul
AU - Horsch, Sandra
AU - Parodi, Alessandro
AU - Pellicer, Adelina
AU - Ramenghi, Luca
AU - Roehr, Charles C.
AU - Steggerda, Sylke
AU - Valverde, Eva
PY - 2020/3/1
Y1 - 2020/3/1
N2 - White matter injury (WMI) is the most frequent form of preterm brain injury. Cranial ultrasound (CUS) remains the preferred modality for initial and sequential neuroimaging in preterm infants, and is reliable for the diagnosis of cystic periventricular leukomalacia. Although magnetic resonance imaging is superior to CUS in detecting the diffuse and more subtle forms of WMI that prevail in very premature infants surviving nowadays, recent improvement in the quality of neonatal CUS imaging has broadened the spectrum of preterm white matter abnormalities that can be detected with this technique. We propose a structured CUS assessment of WMI of prematurity that seeks to account for both cystic and non-cystic changes, as well as signs of white matter loss and impaired brain growth and maturation, at or near term equivalent age. This novel assessment system aims to improve disease description in both routine clinical practice and clinical research. Whether this systematic assessment will improve prediction of outcome in preterm infants with WMI still needs to be evaluated in prospective studies.
AB - White matter injury (WMI) is the most frequent form of preterm brain injury. Cranial ultrasound (CUS) remains the preferred modality for initial and sequential neuroimaging in preterm infants, and is reliable for the diagnosis of cystic periventricular leukomalacia. Although magnetic resonance imaging is superior to CUS in detecting the diffuse and more subtle forms of WMI that prevail in very premature infants surviving nowadays, recent improvement in the quality of neonatal CUS imaging has broadened the spectrum of preterm white matter abnormalities that can be detected with this technique. We propose a structured CUS assessment of WMI of prematurity that seeks to account for both cystic and non-cystic changes, as well as signs of white matter loss and impaired brain growth and maturation, at or near term equivalent age. This novel assessment system aims to improve disease description in both routine clinical practice and clinical research. Whether this systematic assessment will improve prediction of outcome in preterm infants with WMI still needs to be evaluated in prospective studies.
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U2 - 10.1038/s41390-020-0781-1
DO - 10.1038/s41390-020-0781-1
M3 - Review article
C2 - 32218534
AN - SCOPUS:85082561460
VL - 87
SP - 37
EP - 49
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
ER -