We studied three immunoenzymatic techniques designed to evaluate an hypercoagulability status in a group of young leukemic patients (N = 40: age 3-16, sex: 17 F, 23 M) versus a control group of the same age and sex (N = 80; age 5-18, sex: 45 F, 35 M). Our aim was to choose the test that most specifically evidenciates an imbalancement in coagulation homeostasis in leukemic patients treated with L-asparaginase. We performed on our samples the following determinations: prothrombin fragment F1 + 2 (F1 + 2), thrombin-antithrombin complex (TAT), modified antithrombin III (ATM). The precision was satisfactory for each of the three tests, with a CV ranging from 4 to 7%. Pearson's correlation coefficient (r) was determined matching each test versus the other ones. The correlation is highly significant for TAT versus F1 + 2 (r = 0.9165), while it is not so high for TAT versus ATM (r = 0.7972) and F1 + 2 versus ATM (r = 0.7681). The mean values (± 2 SD) for each of the three tests performed on leukemic patients were significantly different (P <0.05) from those of control group. Among our leukemic L-asparaginase treated patients we could observe two cases of thrombosis, which were preceded by a significant increase of the tests hereby described.
|Translated title of the contribution||Prethrombotic markers in leukemic patients: Comparison of three tests|
|Number of pages||6|
|Journal||Giornale Italiano di Chimica Clinica|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Clinical Biochemistry