VALUTAZIONE DELLO STATO IPERCOAGULATIVO IN UNA CASISTICA DI SOGGETTI A RISCHIO: STUDIO DI ALCUNI MARKERS PRETROMBOTICI

Translated title of the contribution: Prethrombotic markers in leukemic patients: Comparison of three tests

F. Cerneca, O. Radillo, R. Simeone, S. De Luyk, M. Mangiarotti

Research output: Contribution to journalArticlepeer-review

Abstract

We studied three immunoenzymatic techniques designed to evaluate an hypercoagulability status in a group of young leukemic patients (N = 40: age 3-16, sex: 17 F, 23 M) versus a control group of the same age and sex (N = 80; age 5-18, sex: 45 F, 35 M). Our aim was to choose the test that most specifically evidenciates an imbalancement in coagulation homeostasis in leukemic patients treated with L-asparaginase. We performed on our samples the following determinations: prothrombin fragment F1 + 2 (F1 + 2), thrombin-antithrombin complex (TAT), modified antithrombin III (ATM). The precision was satisfactory for each of the three tests, with a CV ranging from 4 to 7%. Pearson's correlation coefficient (r) was determined matching each test versus the other ones. The correlation is highly significant for TAT versus F1 + 2 (r = 0.9165), while it is not so high for TAT versus ATM (r = 0.7972) and F1 + 2 versus ATM (r = 0.7681). The mean values (± 2 SD) for each of the three tests performed on leukemic patients were significantly different (P <0.05) from those of control group. Among our leukemic L-asparaginase treated patients we could observe two cases of thrombosis, which were preceded by a significant increase of the tests hereby described.

Translated title of the contributionPrethrombotic markers in leukemic patients: Comparison of three tests
Original languageItalian
Pages (from-to)105-110
Number of pages6
JournalGiornale Italiano di Chimica Clinica
Volume18
Issue number2
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Clinical Biochemistry

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