Pretreatment serum hemoglobin level as a predictive factor of response to neoadjuvant chemotherapy in patients with locally advanced squamous cervical carcinoma: A preliminary report

Luca Fuso, Simona Mazzola, Francesco Marocco, Annamaria Ferrero, Daniela Dompè, Alice Peroglio Carus, Paolo Zola

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. The aim of this study was to evaluate the predictive value of pretreatment serum hemoglobin level (Hb) together with a series of clinical and pathological variables available before neoadjuvant chemotherapy in locally advanced squamous cervical cancer. Methods. The influence on response to neoadjuvant chemotherapy of a series of pretreatment clinico-pathological features: hemoglobin level at diagnosis, age, parity, menopausal status, body mass index, clinical stage, tumor diameter, and nuclear grading were analyzed on 73 patients with locally advanced cervical cancer treated with platinum-based neoadjuvant chemotherapy followed by radical surgery. The relationships between pretreatment variables and response to chemotherapy were assessed in univariate and multivariate settings. A univariate and multivariate logistic regression model was adapted to predict an "optimal" response (pathological complete response or more than 50% reduction in tumoral diameter) or "sub-optimal" response (

Original languageEnglish
JournalGynecologic Oncology
Volume99
Issue number3 SUPPL.
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Hemoglobin
  • Locally advanced squamous cervical cancer
  • Response to chemotherapy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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