Prevalence and antibiotic resistance of 15 minor staphylococcal species colonizing orthopedic implants

Carla Renata Arciola, D. Campoccia, Y. H. An, L. Baldassarri, V. Pirini, M. E. Donati, F. Pegreffi, L. Montanaro

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Several species belonging to Staphylococcus genus nonSau/nonSep species) exhibit increasing abilities as opportunistic pathogens in colonisation of periprosthesis tissues. Here we report on antibiotic resistance of 193 strains, belonging to nonSau/nonSep species, consecutively collected from orthopedic implant infections in a period of about 40 months. The 193 strains (representing 17% of all staphylococci isolated) were analysed for their antibiotic resistance to 16 different drugs. Five species turned out more prevalent, ranging from 1 to 5%: S. hominis (4.2%), S. haemolyticus (3.7%), S. capitis (2.7%), S. warneri (2.6%), and S. cohnii (1.6%). Among these, the prevalence of antibiotic resistance to penicillins was similar, ranging from 51% to 66%. Conversely, significant differences were observed for all the remaining antibiotics. For S. haemolyticus the resistances to oxacillin and imipenem, the four aminoglycosides and erythromycin were at least twice that of the other three species which were compared. S. warneri was on the contrary the species with the lowest occurrence of resistant strains. Ten species appeared only rarely at the infection sites: S. lugdunensis, S. caprae, S. equorum, S. intermedius, S. xylosus, S. simulans, S. saprophyticus, S. pasteuri, S. sciuri, and S. schleiferi. The behaviours of these species, often resistant to penicillins, were individually analysed. Differences in both the frequencies and the panels of antibiotic resistances abserved among the nonSau/nonSep species: i) suggest that horizontal spreading of resistance factors, if acting, was not sufficient per se to level their bio-diversities; ii) highlight and confirm the worrisome appearance within the Staphylococcus genus of emerging "new pathogens", not homogeneous for their virulence and antibiotic resistance prevalence, which deserve to be recognised and treated individually.

Original languageEnglish
Pages (from-to)395-401
Number of pages7
JournalInternational Journal of Artificial Organs
Volume29
Issue number4
Publication statusPublished - Apr 2006

Fingerprint

Orthopedics
Antibiotics
Microbial Drug Resistance
Anti-Bacterial Agents
Staphylococcus
hyaluronate lyase
Penicillins
Pathogens
Oxacillin
Aptitude
Imipenem
R Factors
Aminoglycosides
Erythromycin
Infection
Goats
Biodiversity
Virulence
Tissue
Pharmaceutical Preparations

Keywords

  • Antibiotic resistance
  • Coagulase-negative staphylococci
  • Orthopedic implants
  • Staphylococcus

ASJC Scopus subject areas

  • Biophysics

Cite this

Prevalence and antibiotic resistance of 15 minor staphylococcal species colonizing orthopedic implants. / Arciola, Carla Renata; Campoccia, D.; An, Y. H.; Baldassarri, L.; Pirini, V.; Donati, M. E.; Pegreffi, F.; Montanaro, L.

In: International Journal of Artificial Organs, Vol. 29, No. 4, 04.2006, p. 395-401.

Research output: Contribution to journalArticle

Arciola, CR, Campoccia, D, An, YH, Baldassarri, L, Pirini, V, Donati, ME, Pegreffi, F & Montanaro, L 2006, 'Prevalence and antibiotic resistance of 15 minor staphylococcal species colonizing orthopedic implants', International Journal of Artificial Organs, vol. 29, no. 4, pp. 395-401.
Arciola, Carla Renata ; Campoccia, D. ; An, Y. H. ; Baldassarri, L. ; Pirini, V. ; Donati, M. E. ; Pegreffi, F. ; Montanaro, L. / Prevalence and antibiotic resistance of 15 minor staphylococcal species colonizing orthopedic implants. In: International Journal of Artificial Organs. 2006 ; Vol. 29, No. 4. pp. 395-401.
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