Prevalence and cardiovascular risk profile of chronic kidney disease in Italy

Results of the 2008-12 National Health Examination Survey

Luca De Nicola, Chiara Donfrancesco, Roberto Minutolo, Cinzia Lo Noce, Luigi Palmieri, Amalia De Curtis, Licia Iacoviello, Carmine Zoccali, Loreto Gesualdo, Giuseppe Conte, Diego Vanuzzo, Simona Giampaoli

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background National surveys in countries outside Europe have reported a high prevalence (11-13%) of chronic kidney disease (CKD). Studies in Europe have provided a variable prevalence likely due to differences in study design, including age and extent of geographic areas, equation used to evaluate estimated glomerular filtration rate (eGFR) and CKD stages examined. Methods The 2008-12 National Health Examination Survey in Italy randomly extracted samples from the general population aged 35-79 years, stratified by age and gender, from the resident list of each Italian region (440 persons/1.5 million of residents). We estimated the prevalence of CKD by means of urinary albumin: creatinine ratio and eGFR (CKD-EPI equation-enzymatic assay of serum creatinine). Cardiovascular (CV) risk profile was also evaluated. Results Three thousand eight hundred and forty-eight men and 3704 women were examined. In the whole population, mean age was 57 ± 12 and 56 ± 12 years in men and women, respectively; hypertension was prevalent in men and women, respectively (56 and 43%) and the same held true for overweight (48 and 33%), obesity (26 and 27%), diabetes (14 and 9%) and smoking (21 and 18%), whereas CV disease was less frequent (9 and 6%). Overall, the prevalence of CKD (95% confidence interval) was 7.05% (6.48-7.65). Early stages constituted 59% of the CKD population [Stage G1-2 A2-3: 4.16% (3.71-4.61) and Stage G3-5: 2.89% (2.51-3.26)]. At multivariate regression analysis, age, obesity, hypertension, diabetes, CV disease and smoking were all independent correlates of CKD. Conclusions CKD has a relatively lower prevalence in Italy, in particular for advanced stages, when compared with similar national surveys outside Europe. This occurs despite older age and unfavourable CV risk profile of the whole population.

Original languageEnglish
Pages (from-to)806-814
Number of pages9
JournalNephrology Dialysis Transplantation
Volume30
Issue number5
DOIs
Publication statusPublished - May 1 2015

Fingerprint

Health Surveys
Chronic Renal Insufficiency
Italy
Glomerular Filtration Rate
Population
Creatinine
Cardiovascular Diseases
Obesity
Smoking
Hypertension
Enzyme Assays
varespladib methyl
Albumins
Multivariate Analysis
Regression Analysis
Confidence Intervals
Serum

Keywords

  • albuminuria
  • chronic kidney disease
  • glomerular filtration rate
  • health survey
  • risk profile

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Medicine(all)

Cite this

Prevalence and cardiovascular risk profile of chronic kidney disease in Italy : Results of the 2008-12 National Health Examination Survey. / De Nicola, Luca; Donfrancesco, Chiara; Minutolo, Roberto; Lo Noce, Cinzia; Palmieri, Luigi; De Curtis, Amalia; Iacoviello, Licia; Zoccali, Carmine; Gesualdo, Loreto; Conte, Giuseppe; Vanuzzo, Diego; Giampaoli, Simona.

In: Nephrology Dialysis Transplantation, Vol. 30, No. 5, 01.05.2015, p. 806-814.

Research output: Contribution to journalArticle

De Nicola, L, Donfrancesco, C, Minutolo, R, Lo Noce, C, Palmieri, L, De Curtis, A, Iacoviello, L, Zoccali, C, Gesualdo, L, Conte, G, Vanuzzo, D & Giampaoli, S 2015, 'Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: Results of the 2008-12 National Health Examination Survey', Nephrology Dialysis Transplantation, vol. 30, no. 5, pp. 806-814. https://doi.org/10.1093/ndt/gfu383
De Nicola, Luca ; Donfrancesco, Chiara ; Minutolo, Roberto ; Lo Noce, Cinzia ; Palmieri, Luigi ; De Curtis, Amalia ; Iacoviello, Licia ; Zoccali, Carmine ; Gesualdo, Loreto ; Conte, Giuseppe ; Vanuzzo, Diego ; Giampaoli, Simona. / Prevalence and cardiovascular risk profile of chronic kidney disease in Italy : Results of the 2008-12 National Health Examination Survey. In: Nephrology Dialysis Transplantation. 2015 ; Vol. 30, No. 5. pp. 806-814.
@article{b5fdcbb0ba5048d8bb66bfcf7a465d28,
title = "Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: Results of the 2008-12 National Health Examination Survey",
abstract = "Background National surveys in countries outside Europe have reported a high prevalence (11-13{\%}) of chronic kidney disease (CKD). Studies in Europe have provided a variable prevalence likely due to differences in study design, including age and extent of geographic areas, equation used to evaluate estimated glomerular filtration rate (eGFR) and CKD stages examined. Methods The 2008-12 National Health Examination Survey in Italy randomly extracted samples from the general population aged 35-79 years, stratified by age and gender, from the resident list of each Italian region (440 persons/1.5 million of residents). We estimated the prevalence of CKD by means of urinary albumin: creatinine ratio and eGFR (CKD-EPI equation-enzymatic assay of serum creatinine). Cardiovascular (CV) risk profile was also evaluated. Results Three thousand eight hundred and forty-eight men and 3704 women were examined. In the whole population, mean age was 57 ± 12 and 56 ± 12 years in men and women, respectively; hypertension was prevalent in men and women, respectively (56 and 43{\%}) and the same held true for overweight (48 and 33{\%}), obesity (26 and 27{\%}), diabetes (14 and 9{\%}) and smoking (21 and 18{\%}), whereas CV disease was less frequent (9 and 6{\%}). Overall, the prevalence of CKD (95{\%} confidence interval) was 7.05{\%} (6.48-7.65). Early stages constituted 59{\%} of the CKD population [Stage G1-2 A2-3: 4.16{\%} (3.71-4.61) and Stage G3-5: 2.89{\%} (2.51-3.26)]. At multivariate regression analysis, age, obesity, hypertension, diabetes, CV disease and smoking were all independent correlates of CKD. Conclusions CKD has a relatively lower prevalence in Italy, in particular for advanced stages, when compared with similar national surveys outside Europe. This occurs despite older age and unfavourable CV risk profile of the whole population.",
keywords = "albuminuria, chronic kidney disease, glomerular filtration rate, health survey, risk profile",
author = "{De Nicola}, Luca and Chiara Donfrancesco and Roberto Minutolo and {Lo Noce}, Cinzia and Luigi Palmieri and {De Curtis}, Amalia and Licia Iacoviello and Carmine Zoccali and Loreto Gesualdo and Giuseppe Conte and Diego Vanuzzo and Simona Giampaoli",
year = "2015",
month = "5",
day = "1",
doi = "10.1093/ndt/gfu383",
language = "English",
volume = "30",
pages = "806--814",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Prevalence and cardiovascular risk profile of chronic kidney disease in Italy

T2 - Results of the 2008-12 National Health Examination Survey

AU - De Nicola, Luca

AU - Donfrancesco, Chiara

AU - Minutolo, Roberto

AU - Lo Noce, Cinzia

AU - Palmieri, Luigi

AU - De Curtis, Amalia

AU - Iacoviello, Licia

AU - Zoccali, Carmine

AU - Gesualdo, Loreto

AU - Conte, Giuseppe

AU - Vanuzzo, Diego

AU - Giampaoli, Simona

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background National surveys in countries outside Europe have reported a high prevalence (11-13%) of chronic kidney disease (CKD). Studies in Europe have provided a variable prevalence likely due to differences in study design, including age and extent of geographic areas, equation used to evaluate estimated glomerular filtration rate (eGFR) and CKD stages examined. Methods The 2008-12 National Health Examination Survey in Italy randomly extracted samples from the general population aged 35-79 years, stratified by age and gender, from the resident list of each Italian region (440 persons/1.5 million of residents). We estimated the prevalence of CKD by means of urinary albumin: creatinine ratio and eGFR (CKD-EPI equation-enzymatic assay of serum creatinine). Cardiovascular (CV) risk profile was also evaluated. Results Three thousand eight hundred and forty-eight men and 3704 women were examined. In the whole population, mean age was 57 ± 12 and 56 ± 12 years in men and women, respectively; hypertension was prevalent in men and women, respectively (56 and 43%) and the same held true for overweight (48 and 33%), obesity (26 and 27%), diabetes (14 and 9%) and smoking (21 and 18%), whereas CV disease was less frequent (9 and 6%). Overall, the prevalence of CKD (95% confidence interval) was 7.05% (6.48-7.65). Early stages constituted 59% of the CKD population [Stage G1-2 A2-3: 4.16% (3.71-4.61) and Stage G3-5: 2.89% (2.51-3.26)]. At multivariate regression analysis, age, obesity, hypertension, diabetes, CV disease and smoking were all independent correlates of CKD. Conclusions CKD has a relatively lower prevalence in Italy, in particular for advanced stages, when compared with similar national surveys outside Europe. This occurs despite older age and unfavourable CV risk profile of the whole population.

AB - Background National surveys in countries outside Europe have reported a high prevalence (11-13%) of chronic kidney disease (CKD). Studies in Europe have provided a variable prevalence likely due to differences in study design, including age and extent of geographic areas, equation used to evaluate estimated glomerular filtration rate (eGFR) and CKD stages examined. Methods The 2008-12 National Health Examination Survey in Italy randomly extracted samples from the general population aged 35-79 years, stratified by age and gender, from the resident list of each Italian region (440 persons/1.5 million of residents). We estimated the prevalence of CKD by means of urinary albumin: creatinine ratio and eGFR (CKD-EPI equation-enzymatic assay of serum creatinine). Cardiovascular (CV) risk profile was also evaluated. Results Three thousand eight hundred and forty-eight men and 3704 women were examined. In the whole population, mean age was 57 ± 12 and 56 ± 12 years in men and women, respectively; hypertension was prevalent in men and women, respectively (56 and 43%) and the same held true for overweight (48 and 33%), obesity (26 and 27%), diabetes (14 and 9%) and smoking (21 and 18%), whereas CV disease was less frequent (9 and 6%). Overall, the prevalence of CKD (95% confidence interval) was 7.05% (6.48-7.65). Early stages constituted 59% of the CKD population [Stage G1-2 A2-3: 4.16% (3.71-4.61) and Stage G3-5: 2.89% (2.51-3.26)]. At multivariate regression analysis, age, obesity, hypertension, diabetes, CV disease and smoking were all independent correlates of CKD. Conclusions CKD has a relatively lower prevalence in Italy, in particular for advanced stages, when compared with similar national surveys outside Europe. This occurs despite older age and unfavourable CV risk profile of the whole population.

KW - albuminuria

KW - chronic kidney disease

KW - glomerular filtration rate

KW - health survey

KW - risk profile

UR - http://www.scopus.com/inward/record.url?scp=84929601133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929601133&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfu383

DO - 10.1093/ndt/gfu383

M3 - Article

VL - 30

SP - 806

EP - 814

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 5

ER -