Prevalence and clinical associations of anti-Ku antibodies in systemic autoimmune diseases

Ilaria Cavazzana, A. Ceribelli, M. Quinzanini, M. Scarsi, P. Airò, R. Cattaneo, F. Franceschini

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We retrospectively analysed the prevalence and clinical features associated to anti-Ku antibodies in patients affected by different autoimmune diseases. Anti-Ku antibodies are detected in 147 sera out of 7239 anti-ENA positive sera (2%). They are found in 2% of patients with systemic sclerosis (SSc) (8 out of 379), 1.8% of systemic lupus erythematosus (SLE) (7 out of 372) and 1.8% of undifferentiated connective tissue disease (UCTD) (9 out of 496) and more rarely in Sjögren Syndrome and rheumatoid arthritis. Most of anti-Ku positive patients were affected by UCTD and overlap syndromes, including polymyositis, SSc and SLE. Interstitial lung disease, myositis, articular symptoms, Raynaud's phenomenon and sicca represents the main clinical features detected in our cohort. The rate and severity of pulmonary disease is similar to those found in other SSc patients. Isolated anti-Ku were detected in about 47% of sera. No clinical differences were observed between these patients and subjects with multiple anti-nuclear specificities. However, anti-Ku are usually detected in association with other serological markers in SLE and Sjögren Syndrome, while they occurred isolated in SSc and polymyositis.

Original languageEnglish
Pages (from-to)727-732
Number of pages6
JournalLupus
Volume17
Issue number8
DOIs
Publication statusPublished - 2008

Fingerprint

Systemic Scleroderma
Autoimmune Diseases
Anti-Idiotypic Antibodies
Systemic Lupus Erythematosus
Polymyositis
Serum
Raynaud Disease
Myositis
Connective Tissue Diseases
Interstitial Lung Diseases
Lung Diseases
Rheumatoid Arthritis
Joints

Keywords

  • Anti-ENA
  • Anti-Ku antibodies
  • Overlap syndromes
  • Polymyositis
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Cavazzana, I., Ceribelli, A., Quinzanini, M., Scarsi, M., Airò, P., Cattaneo, R., & Franceschini, F. (2008). Prevalence and clinical associations of anti-Ku antibodies in systemic autoimmune diseases. Lupus, 17(8), 727-732. https://doi.org/10.1177/0961203308089442

Prevalence and clinical associations of anti-Ku antibodies in systemic autoimmune diseases. / Cavazzana, Ilaria; Ceribelli, A.; Quinzanini, M.; Scarsi, M.; Airò, P.; Cattaneo, R.; Franceschini, F.

In: Lupus, Vol. 17, No. 8, 2008, p. 727-732.

Research output: Contribution to journalArticle

Cavazzana, I, Ceribelli, A, Quinzanini, M, Scarsi, M, Airò, P, Cattaneo, R & Franceschini, F 2008, 'Prevalence and clinical associations of anti-Ku antibodies in systemic autoimmune diseases', Lupus, vol. 17, no. 8, pp. 727-732. https://doi.org/10.1177/0961203308089442
Cavazzana, Ilaria ; Ceribelli, A. ; Quinzanini, M. ; Scarsi, M. ; Airò, P. ; Cattaneo, R. ; Franceschini, F. / Prevalence and clinical associations of anti-Ku antibodies in systemic autoimmune diseases. In: Lupus. 2008 ; Vol. 17, No. 8. pp. 727-732.
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