Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome

Y. Shoenfeld, I. Krause, F. Kvapil, J. Sulkes, S. Lev, P. Von Landenberg, J. Font, J. Zaech, R. Cervera, J. C. Piette, M. C. Boffa, M. A. Khamashta, M. L. Bertolaccini, G. R V Hughes, P. Youinou, P. L. Meroni, V. Pengo, J. D. Alves, A. Tincani, G. SzegediG. Lakos, G. Sturfelt, A. Jönsen, T. Koike, M. Sanmarco, A. Ruffatti, Z. Ulcova-Gallova, S. Praprotnik, B. Rozman, M. Lorber, V. B. Vriezman, M. Blank

Research output: Contribution to journalArticle

Abstract

Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-β2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-β2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six β2GPI-related peptides. A high degree of simultaneous reactivity against several β2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the β2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalJournal of Clinical Immunology
Volume23
Issue number5
DOIs
Publication statusPublished - Sep 2003

Keywords

  • Antiphospholipid syndrome
  • Autoimmunity
  • Synthetic peptides
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Shoenfeld, Y., Krause, I., Kvapil, F., Sulkes, J., Lev, S., Von Landenberg, P., Font, J., Zaech, J., Cervera, R., Piette, J. C., Boffa, M. C., Khamashta, M. A., Bertolaccini, M. L., Hughes, G. R. V., Youinou, P., Meroni, P. L., Pengo, V., Alves, J. D., Tincani, A., ... Blank, M. (2003). Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome. Journal of Clinical Immunology, 23(5), 377-383. https://doi.org/10.1023/A:1025321617304