Prevalence and clinical picture of celiac disease in Italian down syndrome patients: A multicenter study

Margherita Bonamico, Paolo Mariani, Helene Maria Danesi, Massimo Crisogianni, Pinella Failla, Gerolamo Gemme, Alberto Rasore Quartino, Aldo Giannotti, Massimo Castro, Fiorella Balli, Margherita Lecora, Generoso Andria, Graziella Guariso, Orazio Gabrielli, Carlo Catassi, Rosanna Lazzari, Nicoletta Ansaldi Balocco, Stefano De Virgiliis, Franco Culasso, Corrado RomanoFrancesca Ferretti, Luigi Corvaglia, Maria Serenella Scotta, Massimo Spina, Novella Rotolo, Mariella Baldassarre, Roberto Ferrari, Franco Bascietto, Franco Colistro, Maria Cristina Digilio, Luigi Memo, Livia Garavelli, Sandra Brusa

Research output: Contribution to journalArticle

Abstract

Background: A multicenter research study of Down syndrome patients was carried out to estimate the prevalence of celiac disease in patients with Down syndrome and to show clinical characteristics and laboratory data of Down syndrome patients. Methods: The authors studied 1,202 Down syndrome patients. Fifty-five celiac disease patients (group 1) were compared with 55 immunoglobulin A antigliadin-positive antiendomysium antibodies-negative patients (group 2) and with 57 immunoglobulin A antigliadin-negative antiendomysium antibodies - negative patients (group 3). Results: Celiac disease was diagnosed in 55 of 1,202 Down syndrome patients (4.6%). In group 1, weight and height percentiles were shifted to the left, whereas these parameters were normally distributed in groups 2 and 3. In celiac patients, diarrhea, vomiting, failure to thrive, anorexia, constipation, and abdominal distension were higher than in the other two groups. Low levels of hemoglobinemia, serum iron, and calcium were observed more frequently in group 1. The diagnosis of celiac disease was made after a mean period of 3.8 years from the initiation of symptoms. Sixty-nine percent of patients showed a classic presentation, 11% had atypical symptoms, and 20% had silent celiac disease. Autoimmune disorders were more frequent (30.9%) in group 1 than in the other two groups examined (15%; P <0.05). Conclusions: This study reconfirms a high prevalence of celiac disease in Down syndrome. However, the diagnostic delay, the detection of atypical symptoms or silent form in one third of the cases, and the increased incidence of autoimmune disorders suggest the need for the screening of celiac disease in all Down syndrome patients.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume33
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Down syndrome
celiac disease
Celiac Disease
Down Syndrome
Multicenter Studies
signs and symptoms (animals and humans)
immunoglobulin A
Immunoglobulin A
failure to thrive
Failure to Thrive
constipation
antibodies
Antibodies
Anorexia
Constipation
vomiting
anorexia
abdomen
Abdomen
Vomiting

Keywords

  • Celiac disease
  • Down syndrome
  • Multicenter study

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Prevalence and clinical picture of celiac disease in Italian down syndrome patients : A multicenter study. / Bonamico, Margherita; Mariani, Paolo; Danesi, Helene Maria; Crisogianni, Massimo; Failla, Pinella; Gemme, Gerolamo; Quartino, Alberto Rasore; Giannotti, Aldo; Castro, Massimo; Balli, Fiorella; Lecora, Margherita; Andria, Generoso; Guariso, Graziella; Gabrielli, Orazio; Catassi, Carlo; Lazzari, Rosanna; Balocco, Nicoletta Ansaldi; De Virgiliis, Stefano; Culasso, Franco; Romano, Corrado; Ferretti, Francesca; Corvaglia, Luigi; Scotta, Maria Serenella; Spina, Massimo; Rotolo, Novella; Baldassarre, Mariella; Ferrari, Roberto; Bascietto, Franco; Colistro, Franco; Digilio, Maria Cristina; Memo, Luigi; Garavelli, Livia; Brusa, Sandra.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 33, No. 2, 2001, p. 139-143.

Research output: Contribution to journalArticle

Bonamico, M, Mariani, P, Danesi, HM, Crisogianni, M, Failla, P, Gemme, G, Quartino, AR, Giannotti, A, Castro, M, Balli, F, Lecora, M, Andria, G, Guariso, G, Gabrielli, O, Catassi, C, Lazzari, R, Balocco, NA, De Virgiliis, S, Culasso, F, Romano, C, Ferretti, F, Corvaglia, L, Scotta, MS, Spina, M, Rotolo, N, Baldassarre, M, Ferrari, R, Bascietto, F, Colistro, F, Digilio, MC, Memo, L, Garavelli, L & Brusa, S 2001, 'Prevalence and clinical picture of celiac disease in Italian down syndrome patients: A multicenter study', Journal of Pediatric Gastroenterology and Nutrition, vol. 33, no. 2, pp. 139-143. https://doi.org/10.1097/00005176-200108000-00008
Bonamico, Margherita ; Mariani, Paolo ; Danesi, Helene Maria ; Crisogianni, Massimo ; Failla, Pinella ; Gemme, Gerolamo ; Quartino, Alberto Rasore ; Giannotti, Aldo ; Castro, Massimo ; Balli, Fiorella ; Lecora, Margherita ; Andria, Generoso ; Guariso, Graziella ; Gabrielli, Orazio ; Catassi, Carlo ; Lazzari, Rosanna ; Balocco, Nicoletta Ansaldi ; De Virgiliis, Stefano ; Culasso, Franco ; Romano, Corrado ; Ferretti, Francesca ; Corvaglia, Luigi ; Scotta, Maria Serenella ; Spina, Massimo ; Rotolo, Novella ; Baldassarre, Mariella ; Ferrari, Roberto ; Bascietto, Franco ; Colistro, Franco ; Digilio, Maria Cristina ; Memo, Luigi ; Garavelli, Livia ; Brusa, Sandra. / Prevalence and clinical picture of celiac disease in Italian down syndrome patients : A multicenter study. In: Journal of Pediatric Gastroenterology and Nutrition. 2001 ; Vol. 33, No. 2. pp. 139-143.
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abstract = "Background: A multicenter research study of Down syndrome patients was carried out to estimate the prevalence of celiac disease in patients with Down syndrome and to show clinical characteristics and laboratory data of Down syndrome patients. Methods: The authors studied 1,202 Down syndrome patients. Fifty-five celiac disease patients (group 1) were compared with 55 immunoglobulin A antigliadin-positive antiendomysium antibodies-negative patients (group 2) and with 57 immunoglobulin A antigliadin-negative antiendomysium antibodies - negative patients (group 3). Results: Celiac disease was diagnosed in 55 of 1,202 Down syndrome patients (4.6{\%}). In group 1, weight and height percentiles were shifted to the left, whereas these parameters were normally distributed in groups 2 and 3. In celiac patients, diarrhea, vomiting, failure to thrive, anorexia, constipation, and abdominal distension were higher than in the other two groups. Low levels of hemoglobinemia, serum iron, and calcium were observed more frequently in group 1. The diagnosis of celiac disease was made after a mean period of 3.8 years from the initiation of symptoms. Sixty-nine percent of patients showed a classic presentation, 11{\%} had atypical symptoms, and 20{\%} had silent celiac disease. Autoimmune disorders were more frequent (30.9{\%}) in group 1 than in the other two groups examined (15{\%}; P <0.05). Conclusions: This study reconfirms a high prevalence of celiac disease in Down syndrome. However, the diagnostic delay, the detection of atypical symptoms or silent form in one third of the cases, and the increased incidence of autoimmune disorders suggest the need for the screening of celiac disease in all Down syndrome patients.",
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T1 - Prevalence and clinical picture of celiac disease in Italian down syndrome patients

T2 - A multicenter study

AU - Bonamico, Margherita

AU - Mariani, Paolo

AU - Danesi, Helene Maria

AU - Crisogianni, Massimo

AU - Failla, Pinella

AU - Gemme, Gerolamo

AU - Quartino, Alberto Rasore

AU - Giannotti, Aldo

AU - Castro, Massimo

AU - Balli, Fiorella

AU - Lecora, Margherita

AU - Andria, Generoso

AU - Guariso, Graziella

AU - Gabrielli, Orazio

AU - Catassi, Carlo

AU - Lazzari, Rosanna

AU - Balocco, Nicoletta Ansaldi

AU - De Virgiliis, Stefano

AU - Culasso, Franco

AU - Romano, Corrado

AU - Ferretti, Francesca

AU - Corvaglia, Luigi

AU - Scotta, Maria Serenella

AU - Spina, Massimo

AU - Rotolo, Novella

AU - Baldassarre, Mariella

AU - Ferrari, Roberto

AU - Bascietto, Franco

AU - Colistro, Franco

AU - Digilio, Maria Cristina

AU - Memo, Luigi

AU - Garavelli, Livia

AU - Brusa, Sandra

PY - 2001

Y1 - 2001

N2 - Background: A multicenter research study of Down syndrome patients was carried out to estimate the prevalence of celiac disease in patients with Down syndrome and to show clinical characteristics and laboratory data of Down syndrome patients. Methods: The authors studied 1,202 Down syndrome patients. Fifty-five celiac disease patients (group 1) were compared with 55 immunoglobulin A antigliadin-positive antiendomysium antibodies-negative patients (group 2) and with 57 immunoglobulin A antigliadin-negative antiendomysium antibodies - negative patients (group 3). Results: Celiac disease was diagnosed in 55 of 1,202 Down syndrome patients (4.6%). In group 1, weight and height percentiles were shifted to the left, whereas these parameters were normally distributed in groups 2 and 3. In celiac patients, diarrhea, vomiting, failure to thrive, anorexia, constipation, and abdominal distension were higher than in the other two groups. Low levels of hemoglobinemia, serum iron, and calcium were observed more frequently in group 1. The diagnosis of celiac disease was made after a mean period of 3.8 years from the initiation of symptoms. Sixty-nine percent of patients showed a classic presentation, 11% had atypical symptoms, and 20% had silent celiac disease. Autoimmune disorders were more frequent (30.9%) in group 1 than in the other two groups examined (15%; P <0.05). Conclusions: This study reconfirms a high prevalence of celiac disease in Down syndrome. However, the diagnostic delay, the detection of atypical symptoms or silent form in one third of the cases, and the increased incidence of autoimmune disorders suggest the need for the screening of celiac disease in all Down syndrome patients.

AB - Background: A multicenter research study of Down syndrome patients was carried out to estimate the prevalence of celiac disease in patients with Down syndrome and to show clinical characteristics and laboratory data of Down syndrome patients. Methods: The authors studied 1,202 Down syndrome patients. Fifty-five celiac disease patients (group 1) were compared with 55 immunoglobulin A antigliadin-positive antiendomysium antibodies-negative patients (group 2) and with 57 immunoglobulin A antigliadin-negative antiendomysium antibodies - negative patients (group 3). Results: Celiac disease was diagnosed in 55 of 1,202 Down syndrome patients (4.6%). In group 1, weight and height percentiles were shifted to the left, whereas these parameters were normally distributed in groups 2 and 3. In celiac patients, diarrhea, vomiting, failure to thrive, anorexia, constipation, and abdominal distension were higher than in the other two groups. Low levels of hemoglobinemia, serum iron, and calcium were observed more frequently in group 1. The diagnosis of celiac disease was made after a mean period of 3.8 years from the initiation of symptoms. Sixty-nine percent of patients showed a classic presentation, 11% had atypical symptoms, and 20% had silent celiac disease. Autoimmune disorders were more frequent (30.9%) in group 1 than in the other two groups examined (15%; P <0.05). Conclusions: This study reconfirms a high prevalence of celiac disease in Down syndrome. However, the diagnostic delay, the detection of atypical symptoms or silent form in one third of the cases, and the increased incidence of autoimmune disorders suggest the need for the screening of celiac disease in all Down syndrome patients.

KW - Celiac disease

KW - Down syndrome

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