Prevalence and clinical relevance of hepatitis C virus viremia in patients on chronic hemodialysis

Filippo Aucella, Michele Centra, Antonio Gesuete, Giuseppe Lucio Valiente, Michele Vergura, Elisabetta Martini, Giuseppe Di Giorgio, Carmine Stallone

Research output: Contribution to journalArticle

Abstract

Patients on routine hemodialysis (HD) present a high prevalence of anti-HCV+, but a low frequency of clinical signs of liver disease. To assess the prevalence of hepatitis C virus viremia in HD patients, 53 anti-HCV+ and 28 anti-HCV- patients on chronic dialysis were examined. Viral RNA was investigated using two polymerase chain reaction (PCR) techniques. Viremia was detected in 34 of 53 (64.1%, with PCR-1) and in 35 of 53 (66%, with PCR-2) anti-HCV+ and in 1 of 28 anti-HCV-(3.5%) (PCR-1 and -2). Time spent on dialysis, blood transfusion and chronic liver disease were comparable in PCR+ and PCR- patients, but acute liver disease occurred more frequently in PCR+ patients (p

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalJournal of Nephrology
Volume9
Issue number2
Publication statusPublished - Mar 1996

Keywords

  • Hemodialysis
  • Hepatitis C virus
  • Liver disease
  • Polymerase chain reaction
  • Viral infection
  • Viremia

ASJC Scopus subject areas

  • Nephrology

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    Aucella, F., Centra, M., Gesuete, A., Valiente, G. L., Vergura, M., Martini, E., Di Giorgio, G., & Stallone, C. (1996). Prevalence and clinical relevance of hepatitis C virus viremia in patients on chronic hemodialysis. Journal of Nephrology, 9(2), 88-92.