Prevalence and consistency of low breath H2 excretion following lactulose ingestion - Possible implications for the clinical use of the H2 breath test

Ginoroberto Corazza, Alessandra Strocchi, Margherita Sorge, Giuseppe Benati, Giovanni Gasbarrini

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical use of the H2 breath test is limited by the finding that a variable fraction of the population fails to excrete appreciable H2 during colonic carbohydrate fermentation. Therefore, we assessed the ability to increase breath H2 excretion in 371 patients (224 female, 147 male) by administering the nonabsorbable sugar lactulose. Following 12 g of lactulose, 27% of 94 patients did not increase their breath H2 concentration over 20 ppm and were considered low H2 excretors. Ingestion of 20 g of lactulose in 277 patients yielded a frequency of low H2 excretors of 14%. Six of 10 patients that were low H2 excretors after 12 g of lactulose increased their breath H2 levels over 20 ppm when tested with 20 g. In 35 patients tested with the same amount of lactulose on two separate occasions, the subject frequently altered his or her H2 producing status over a period of a few weeks. Low H2 excretors had a significantly higher breath CH4 concentration, both fasting (22 ± 34 ppm) and after lactulose (51 ± 58 ppm) compared to the remaining patients (5 ± 13 ppm and 16 ± 40 ppm, respectively). While the mean age of low excretors (54 ± 17 years) was significantly higher than the others (44 ± 17 years), no difference was found for sex prevalence and stool pH. This study demonstrates that respiratory H2 excretion following lactulose ingestion is not consistent and suggests that the application of too restrictive criteria could lead to improper interpretation of the H2 breath test.

Original languageEnglish
Pages (from-to)2010-2016
Number of pages7
JournalDigestive Diseases and Sciences
Volume38
Issue number11
DOIs
Publication statusPublished - Nov 1993

Keywords

  • carbohydrate malabsorption
  • hydrogen production
  • intestinal gas
  • methanogenesis

ASJC Scopus subject areas

  • Gastroenterology

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