Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries

C E Lloyd; A Nouwen; N Sartorius; H U Ahmed; A Alvarez; S Bahendeka; D Basangwa; A E Bobrov; S Boden; V Bulgari; L Burti; S K Chaturvedi; L C Cimino; W Gaebel; G de Girolamo; T M Gondek; M Guinzbourg de Braude; A Guntupalli; M G Heinze; L Ji; X Hong; A Khan; A Kiejna; A Kokoszka; T Kamala; N M Lalic; D Lecic Tosevski; B Mankovsky; M Li; A Musau; K Müssig; D Ndetei; G Rabbani; S S Srikanta; E G Starostina; M Shevchuk; R Taj; O Vukovic; W Wölwer; Y Xin

doi:10.1111/dme.13611

Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries

C E Lloyd, A Nouwen, N Sartorius, H U Ahmed, A Alvarez, S Bahendeka, D Basangwa, A E Bobrov, S Boden, V Bulgari, L Burti, S K Chaturvedi, L C Cimino, W Gaebel, G de Girolamo, T M Gondek, M Guinzbourg de Braude, A Guntupalli, M G Heinze, L JiX Hong, A Khan, A Kiejna, A Kokoszka, T Kamala, N M Lalic, D Lecic Tosevski, B Mankovsky, M Li, A Musau, K Müssig, D Ndetei, G Rabbani, S S Srikanta, E G Starostina, M Shevchuk, R Taj, O Vukovic, W Wölwer, Y Xin

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article

Abstract

AIMS: To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries.

METHODS: People with diabetes aged 18-65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected.

RESULTS: A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (P<0.0001), a lower level of education (P<0.05), doing less exercise (P<0.01), higher levels of diabetes distress (P<0.0001) and a previous diagnosis of major depressive disorder (P<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0-29.6%).

CONCLUSIONS: Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes.

Original language	English
Pages (from-to)	760-769
Number of pages	10
Journal	Diabetic Medicine
Volume	35
Issue number	6
DOIs	https://doi.org/10.1111/dme.13611
Publication status	Published - Jun 2018

Keywords

Adolescent
Adult
Aged
Depressive Disorder, Major/epidemiology
Diabetes Mellitus, Type 2/drug therapy
Female
Global Health
Humans
Hypoglycemic Agents/therapeutic use
Insulin/therapeutic use
Male
Middle Aged
Prevalence
Young Adult

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Lloyd, C. E., Nouwen, A., Sartorius, N., Ahmed, H. U., Alvarez, A., Bahendeka, S., Basangwa, D., Bobrov, A. E., Boden, S., Bulgari, V., Burti, L., Chaturvedi, S. K., Cimino, L. C., Gaebel, W., de Girolamo, G., Gondek, T. M., de Braude, M. G., Guntupalli, A., Heinze, M. G., ... Xin, Y. (2018). Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries. Diabetic Medicine, 35(6), 760-769. https://doi.org/10.1111/dme.13611

Prevalence and correlates of depressive disorders in people with Type 2 diabetes : results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries. / Lloyd, C E; Nouwen, A; Sartorius, N; Ahmed, H U; Alvarez, A; Bahendeka, S; Basangwa, D; Bobrov, A E; Boden, S; Bulgari, V; Burti, L; Chaturvedi, S K; Cimino, L C; Gaebel, W; de Girolamo, G; Gondek, T M; de Braude, M Guinzbourg; Guntupalli, A; Heinze, M G; Ji, L; Hong, X; Khan, A; Kiejna, A; Kokoszka, A; Kamala, T; Lalic, N M; Lecic Tosevski, D; Mankovsky, B; Li, M; Musau, A; Müssig, K; Ndetei, D; Rabbani, G; Srikanta, S S; Starostina, E G; Shevchuk, M; Taj, R; Vukovic, O; Wölwer, W; Xin, Y.

In: Diabetic Medicine, Vol. 35, No. 6, 06.2018, p. 760-769.

Research output: Contribution to journal › Article

Lloyd, CE, Nouwen, A, Sartorius, N, Ahmed, HU, Alvarez, A, Bahendeka, S, Basangwa, D, Bobrov, AE, Boden, S, Bulgari, V, Burti, L, Chaturvedi, SK, Cimino, LC, Gaebel, W, de Girolamo, G, Gondek, TM, de Braude, MG, Guntupalli, A, Heinze, MG, Ji, L, Hong, X, Khan, A, Kiejna, A, Kokoszka, A, Kamala, T, Lalic, NM, Lecic Tosevski, D, Mankovsky, B, Li, M, Musau, A, Müssig, K, Ndetei, D, Rabbani, G, Srikanta, SS, Starostina, EG, Shevchuk, M, Taj, R, Vukovic, O, Wölwer, W & Xin, Y 2018, 'Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries', Diabetic Medicine, vol. 35, no. 6, pp. 760-769. https://doi.org/10.1111/dme.13611

Lloyd CE, Nouwen A, Sartorius N, Ahmed HU, Alvarez A, Bahendeka S et al. Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries. Diabetic Medicine. 2018 Jun;35(6):760-769. https://doi.org/10.1111/dme.13611

Lloyd, C E ; Nouwen, A ; Sartorius, N ; Ahmed, H U ; Alvarez, A ; Bahendeka, S ; Basangwa, D ; Bobrov, A E ; Boden, S ; Bulgari, V ; Burti, L ; Chaturvedi, S K ; Cimino, L C ; Gaebel, W ; de Girolamo, G ; Gondek, T M ; de Braude, M Guinzbourg ; Guntupalli, A ; Heinze, M G ; Ji, L ; Hong, X ; Khan, A ; Kiejna, A ; Kokoszka, A ; Kamala, T ; Lalic, N M ; Lecic Tosevski, D ; Mankovsky, B ; Li, M ; Musau, A ; Müssig, K ; Ndetei, D ; Rabbani, G ; Srikanta, S S ; Starostina, E G ; Shevchuk, M ; Taj, R ; Vukovic, O ; Wölwer, W ; Xin, Y. / Prevalence and correlates of depressive disorders in people with Type 2 diabetes : results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries. In: Diabetic Medicine. 2018 ; Vol. 35, No. 6. pp. 760-769.

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title = "Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries",

abstract = "AIMS: To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries.METHODS: People with diabetes aged 18-65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected.RESULTS: A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (P<0.0001), a lower level of education (P<0.05), doing less exercise (P<0.01), higher levels of diabetes distress (P<0.0001) and a previous diagnosis of major depressive disorder (P<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0-29.6%).CONCLUSIONS: Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes.",

keywords = "Adolescent, Adult, Aged, Depressive Disorder, Major/epidemiology, Diabetes Mellitus, Type 2/drug therapy, Female, Global Health, Humans, Hypoglycemic Agents/therapeutic use, Insulin/therapeutic use, Male, Middle Aged, Prevalence, Young Adult",

author = "Lloyd, {C E} and A Nouwen and N Sartorius and Ahmed, {H U} and A Alvarez and S Bahendeka and D Basangwa and Bobrov, {A E} and S Boden and V Bulgari and L Burti and Chaturvedi, {S K} and Cimino, {L C} and W Gaebel and {de Girolamo}, G and Gondek, {T M} and {de Braude}, {M Guinzbourg} and A Guntupalli and Heinze, {M G} and L Ji and X Hong and A Khan and A Kiejna and A Kokoszka and T Kamala and Lalic, {N M} and {Lecic Tosevski}, D and B Mankovsky and M Li and A Musau and K M{\"u}ssig and D Ndetei and G Rabbani and Srikanta, {S S} and Starostina, {E G} and M Shevchuk and R Taj and O Vukovic and W W{\"o}lwer and Y Xin",

note = "{\textcopyright} 2018 Diabetes UK.",

year = "2018",

month = jun,

doi = "10.1111/dme.13611",

language = "English",

volume = "35",

pages = "760--769",

journal = "Diabetic Medicine",

issn = "0742-3071",

publisher = "Wiley-Blackwell",

number = "6",

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TY - JOUR

T1 - Prevalence and correlates of depressive disorders in people with Type 2 diabetes

T2 - results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries

AU - Lloyd, C E

AU - Nouwen, A

AU - Sartorius, N

AU - Ahmed, H U

AU - Alvarez, A

AU - Bahendeka, S

AU - Basangwa, D

AU - Bobrov, A E

AU - Boden, S

AU - Bulgari, V

AU - Burti, L

AU - Chaturvedi, S K

AU - Cimino, L C

AU - Gaebel, W

AU - de Girolamo, G

AU - Gondek, T M

AU - de Braude, M Guinzbourg

AU - Guntupalli, A

AU - Heinze, M G

AU - Ji, L

AU - Hong, X

AU - Khan, A

AU - Kiejna, A

AU - Kokoszka, A

AU - Kamala, T

AU - Lalic, N M

AU - Lecic Tosevski, D

AU - Mankovsky, B

AU - Li, M

AU - Musau, A

AU - Müssig, K

AU - Ndetei, D

AU - Rabbani, G

AU - Srikanta, S S

AU - Starostina, E G

AU - Shevchuk, M

AU - Taj, R

AU - Vukovic, O

AU - Wölwer, W

AU - Xin, Y

PY - 2018/6

Y1 - 2018/6

N2 - AIMS: To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries.METHODS: People with diabetes aged 18-65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected.RESULTS: A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (P<0.0001), a lower level of education (P<0.05), doing less exercise (P<0.01), higher levels of diabetes distress (P<0.0001) and a previous diagnosis of major depressive disorder (P<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0-29.6%).CONCLUSIONS: Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes.

AB - AIMS: To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries.METHODS: People with diabetes aged 18-65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected.RESULTS: A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (P<0.0001), a lower level of education (P<0.05), doing less exercise (P<0.01), higher levels of diabetes distress (P<0.0001) and a previous diagnosis of major depressive disorder (P<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0-29.6%).CONCLUSIONS: Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes.

KW - Adolescent

KW - Adult

KW - Aged

KW - Depressive Disorder, Major/epidemiology

KW - Diabetes Mellitus, Type 2/drug therapy

KW - Female

KW - Global Health

KW - Humans

KW - Hypoglycemic Agents/therapeutic use

KW - Insulin/therapeutic use

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Young Adult

U2 - 10.1111/dme.13611

DO - 10.1111/dme.13611

M3 - Article

C2 - 29478265

VL - 35

SP - 760

EP - 769

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 6

ER -