Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients: the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study

Marco Bertolotti, Carlotta Franchi, Marco B.L. Rocchi, Andrea Miceli, M. Vittoria Libbra, Alessandro Nobili, Giulia Lancellotti, Lucia Carulli, Chiara Mussi, Pier Mannuccio Mannucci, Mauro Tettamanti, Luca Pasina, Francesco Perticone, Francesco Salerno, Salvatore Corrao, Alessandra Marengoni, Giuseppe Licata, Francesco Violi, Gino Roberto Corazza, Maura MarcucciTarek Kamal Eldin, Maria Pia Donatella Di Blanca, Giovanna Lanzo, Sarah Astuto, Ilaria Ardoino, Laura Cortesi, Domenico Prisco, Elena Silvestri, Caterina Cenci, Giacomo Emmi, Gianni Biolo, Gianfranco Guarnieri, Michela Zanetti, Giovanni Fernandes, Massimiliano Chiuch, Massimo Vanoli, Giulia Grignani, Gianluca Casella, Edoardo Alessandro Pulixi, Mauro Bernardi, Silvia Li Bassi, Luca Santi, Giacomo Zaccherini, Elmo Mannarino, Graziana Lupattelli, Vanessa Bianconi, Francesco Paciullo, Ranuccio Nuti, Roberto Valenti, Martina Ruvio, Silvia Cappelli, Alberto Palazzuoli, Teresa Salvatore, Ferdinando Carlo Sasso, Domenico Girelli, Oliviero Olivieri, Thomas Matteazzi, Mario Barbagallo, Lidia Plances, Roberta Alcamo, Luigi Calvo, Maria Valenti, Franco Laghi Pasini, Pier Leopoldo Capecchi, Maurizio Bicchi, Giuseppe Palasciano, Maria Ester Modeo, Maria Peragine, Fabrizio Pappagallo, Stefania Pugliese, Carla Di Gennaro, Alfredo Postiglione, Maria Rosaria Barbella, Francesco De Stefano, Maria Domenica Cappellini, Giovanna Fabio, Sonia Seghezzi, Margherita Migone De Amicis, Marta Mancarella, Daniela Mari, Paolo Dionigi Rossi, Sarah Damanti, Barbara Brignolo Ottolini, Giulia Bonini, Emanuela Miceli, Marco Vincenzo Lenti, Donatella Padula, Giovanni Murialdo, Alessio Marra, Federico Cattaneo, Maria Beatrice Secchi, Davide Ghelfi, Luigi Anastasio, Lucia Sofia, Maria Carbone, Giovanni Davì, Maria Teresa Guagnano, Simona Sestili, Gerardo Mancuso, Daniela Calipari, Mosè Bartone, Maria Rachele Meroni, Paolo Cavallo Perin, Bartolomeo Lorenzati, Gabriella Gruden, Graziella Bruno, Cristina Amione, Paolo Fornengo, Rodolfo Tassara, Deborah Melis, Lara Rebella, Giuseppe Delitala, Vincenzo Pretti, Maristella Salvatora Masala, Chiara Pes, Luigi Bolondi, Leonardo Rasciti, Ilaria Serio, Filippo Rossi Fanelli, Antonio Amoroso, Alessio Molfino, Enrico Petrillo, Giuseppe Zuccalà, Francesco Franceschi, Guido De Marco, Cordischi Chiara, Sabbatini Marta, Gabriella D’Aurizio, Giuseppe Romanelli, Claudia Amolini, Deborah Chiesa, Antonio Picardi, Umberto Vespasiani Gentilucci, Paolo Gallo, Giorgio Annoni, Maurizio Corsi, Sara Zazzetta, Giuseppe Bellelli, Hajnalka Szabo, Franco Arturi, Elena Succurro, Mariangela Rubino, Giorgio Sesti, Paola Loria, Maria Angela Becchi, Gianfranco Martucci, Alessandra Fantuzzi, Mauro Maurantonio, Maria Grazia Serra, Maria Antonietta Bleve, Laura Gasbarrone, Maria Rosaria Sajeva, Antonio Brucato, Silvia Ghidoni, Paola Di Corato, Giancarlo Agnelli, Emanuela Marchesini, Fabrizio Fabris, Michela Carlon, Francesca Turatto, Aldo Baritusso, Annalisa Amabile, Elisabetta Omenetto, Paolo Scarinzi, Roberto Manfredini, Christian Molino, Marco Pala, Fabio Fabbian, Benedetta Boari, Alfredo De Giorgi, Giuseppe Paolisso, Maria Rosaria Rizzo, Maria Teresa Laieta, Giovanbattista Rini, Pasquale Mansueto, Ilenia Pepe, Claudio Borghi, Enrico Strocchi, Valeria De Sando, Ilaria Pareo, Carlo Sabbà, Francesco Saverio Vella, Patrizia Suppressa, Raffaella Valerio, Pasquale Agosti, Flavia Fontana, Francesca Loparco, Caterina Capobianco, Luigi Fenoglio, Christian Bracco, Alessia Valentina Giraudo, Elisa Testa, Cristina Serraino, Silvia Fargion, Paola Bonara, Giulia Periti, Marianna Porzio, Slivia Tiraboschi, Flora Peyvandi, Alberto Tedeschi, Raffaella Rossio, Barbara Ferrari, Valter Monzani, Valeria Savojardo, Christian Folli, Maria Magnini Francesco Salerno, Alessio Conca, Giulia Gobbo, Giada Pallini, Miriam Valenti, Carlo L. Balduini, Giampiera Bertolino, Stella Provini, Federica Quaglia, Franco Dallegri, Luciano Ottonello, Luca Liberale, Wu Sheng Chin, Laura Carassale, Silvia Caporotundo, Giancarlo Traisci, Lucrezia De Feudis, Silvia Di Carlo, Nicola Lucio Liberato, Alberto Buratti, Tiziana Tognin, Giovanni Battista Bianchi, Sabrina Giaquinto, Francesco Purrello, Antonino Di Pino, Salvatore Piro, Renzo Rozzini, Lina Falanga, Elena Spazzini, Giuseppe Montrucchio, Elisabetta Greco, Pietro Tizzani, Paolo Petitti, Antonio Perciccante, Alessia Coralli, Raffaella Salmi, Piergiorgio Gaudenzi, Susanna Gamberini, Andrea Semplicini, Lucia Gottardo, Gianluigi Vendemiale, Gaetano Serviddio, Roberta Forlano, Cesare Masala, Antonio Mammarella, Valeria Raparelli, Stefania Basili, Ludovica Perri, Raffaele Landolfi, Massimo Montalto, Antonio Mirijello, Carla Vallone, Martino Bellusci, Donatella Setti, Filippo Pedrazzoli, Luigina Guasti, Luana Castiglioni, Andrea Maresca, Alessandro Squizzato, Marta Molaro, Elisa Pellegrini, Francesca Veltri, Angela Sciacqua, Michele Quero, Chiara Bagnato, Lidia Colangelo, Tania Falbo, Roberto De Giorgio, Mauro Serra, Valentina Grasso, Eugenio Ruggeri, Benzoni Ilaria, Andrea Salvi, Roberto Leonardi, Chiara Grassini, Ilenia Mascherona, Giorgio Minelli, Francesca Maltese, Giampaolo Damiani, William Capeci, Massimo Mattioli, Giuseppe Pio Martino, Lorenzo Biondi, Monica Ormas, Pietro Pettinari, Roberto Romiti, Silvia Messina, Federica Cavallaro, Riccardi Ghio, Serena Favorini, Anna Dal Col, Salvatore Minisola, Luciano Colangelo, Antonella Afeltra, Pamela Alemanno, Benedetta Marigliano, Maria Elena Pipita, Pietro Castellino, Julien Blanco, Luca Zanoli, Marco Cattaneo, Paola Fracasso, Maria Valentina Amoruso, Valter Saracco, Marisa Fogliati, Carlo Bussolino, Vittorio Durante, Giovanna Eusebi, Daniela Tirotta, Francesca Mete, Miriam Gino, Antonio Cittadini, Carlo Vigorito, Michele Arcopinto, Andrea Salzano, Emanuele Bobbio, Alberto Maria Marra, Domenico Sirico, Guido Moreo, Francesco Scopelliti, Francesca Gasparini, Melissa Cocca, Alberto Ballestrero, Fabio Ferrando, Sergio Berra, Simonetta Dassi, Maria Cristina Nava, Bruno Graziella, Stefano Baldassarre, Salvatore Fragapani, Giorgio Galanti, Gabriele Mascherini, Cristian Petri, Laura Stefani, Margherita Girino, Valeria Piccinelli, Francesco Nasso, Vincenza Gioffrè, Maria Pasquale, Giuseppe Scattolin, Sergio Martinelli, Mauro Turrin, Leonardo Sechi, Cristina Catena, Gianluca Colussi, Ramirez Duque Nieves, Muela Molinero Alberto, Abad Requejo Pedro, Lopez Pelaez Vanessa, Tamargo Lara, Corbella Viros Xavier, Formiga Francesc, Diez Manglano Jesus, Bejarano Tello Esperanza, Del Corral Behamonte Esther, Sevil Puras Maria, Manuel Romero, Pinilla Llorente Blanca, Lopez Gonzalez Cobos Cristina, Villalba Garcia M. Victoria, Lopez Saez, Juan Bosco, Sanz Baena Susana, Arroyo Gallego Marta, Gonzalez Becerra Concepcion, Fernandez Moyano Antonio, Mercedes Gomez Hernandez, Manuel Poyato Borrego, Pacheco Cuadros Raquel, Perez Rojas Florencia, Garcia Olid Beatriz, Carrascosa Garcia Sara, Gonzalez Cruz Cervellera Alfonso, Peinado Martinez Marta, Sara Carrascosa Garcia, Ruiz Cantero Alberto, Albarracín Arraigosa Antonio, Godoy Guerrero Montserrat, Barón Ramos Miguel Ángel, Machin Jose Manuel, Novo Veleiro Ignacio, Alvela Suarez Lucía, Lopez Alfonso, Rubal Bran David, Iñiguez Vazquez Iria, Rios Prego Monica

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. Aim: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. Methods: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical profiles, including multimorbidity markers and polypharmacy. Results: 2171 patients aged >65 years were enrolled (1057 males, 1114 females, mean age 78.6 years). The patients treated with lipid-lowering drugs amounted to 508 subjects (23.4%), with no gender difference. Atorvastatin (39.3%) and simvastatin (34.0%) were the most widely used statin drugs. Likelihood of treatment was associated with polypharmacy (≥5 drugs) and with higher Cumulative Illness Rating Scale (CIRS) score. At logistic regression analysis, the presence of coronary heart disease, peripheral vascular disease, and hypertension were significantly correlated with lipid-lowering drug use, whereas age showed an inverse correlation. Diabetes was not associated with drug treatment. Conclusions: In this in-hospital cohort, the use of lipid-lowering agents was mainly driven by patients’ clinical history, most notably the presence of clinically overt manifestations of atherosclerosis. Increasing age seems to be associated with lower prescription rates. This might be indicative of cautious behavior towards a potentially toxic treatment regimen.

Original languageEnglish
Pages (from-to)311-319
Number of pages9
JournalDrugs and Aging
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

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Lipids
Polypharmacy
Pharmaceutical Preparations
Population
Comorbidity
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Simvastatin
Peripheral Vascular Diseases
Poisons
Therapeutics
Internal Medicine
Drug Interactions
Geriatrics
Prescriptions
Coronary Disease
Atherosclerosis
Logistic Models
Regression Analysis
Medicine
Hypertension

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Pharmacology (medical)

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Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients : the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study. / Bertolotti, Marco; Franchi, Carlotta; Rocchi, Marco B.L.; Miceli, Andrea; Libbra, M. Vittoria; Nobili, Alessandro; Lancellotti, Giulia; Carulli, Lucia; Mussi, Chiara; Mannucci, Pier Mannuccio; Tettamanti, Mauro; Pasina, Luca; Perticone, Francesco; Salerno, Francesco; Corrao, Salvatore; Marengoni, Alessandra; Licata, Giuseppe; Violi, Francesco; Corazza, Gino Roberto; Marcucci, Maura; Eldin, Tarek Kamal; Di Blanca, Maria Pia Donatella; Lanzo, Giovanna; Astuto, Sarah; Ardoino, Ilaria; Cortesi, Laura; Prisco, Domenico; Silvestri, Elena; Cenci, Caterina; Emmi, Giacomo; Biolo, Gianni; Guarnieri, Gianfranco; Zanetti, Michela; Fernandes, Giovanni; Chiuch, Massimiliano; Vanoli, Massimo; Grignani, Giulia; Casella, Gianluca; Pulixi, Edoardo Alessandro; Bernardi, Mauro; Bassi, Silvia Li; Santi, Luca; Zaccherini, Giacomo; Mannarino, Elmo; Lupattelli, Graziana; Bianconi, Vanessa; Paciullo, Francesco; Nuti, Ranuccio; Valenti, Roberto; Ruvio, Martina; Cappelli, Silvia; Palazzuoli, Alberto; Salvatore, Teresa; Sasso, Ferdinando Carlo; Girelli, Domenico; Olivieri, Oliviero; Matteazzi, Thomas; Barbagallo, Mario; Plances, Lidia; Alcamo, Roberta; Calvo, Luigi; Valenti, Maria; Pasini, Franco Laghi; Capecchi, Pier Leopoldo; Bicchi, Maurizio; Palasciano, Giuseppe; Modeo, Maria Ester; Peragine, Maria; Pappagallo, Fabrizio; Pugliese, Stefania; Di Gennaro, Carla; Postiglione, Alfredo; Barbella, Maria Rosaria; De Stefano, Francesco; Cappellini, Maria Domenica; Fabio, Giovanna; Seghezzi, Sonia; De Amicis, Margherita Migone; Mancarella, Marta; Mari, Daniela; Rossi, Paolo Dionigi; Damanti, Sarah; Ottolini, Barbara Brignolo; Bonini, Giulia; Miceli, Emanuela; Lenti, Marco Vincenzo; Padula, Donatella; Murialdo, Giovanni; Marra, Alessio; Cattaneo, Federico; Secchi, Maria Beatrice; Ghelfi, Davide; Anastasio, Luigi; Sofia, Lucia; Carbone, Maria; Davì, Giovanni; Guagnano, Maria Teresa; Sestili, Simona; Mancuso, Gerardo; Calipari, Daniela; Bartone, Mosè; Meroni, Maria Rachele; Perin, Paolo Cavallo; Lorenzati, Bartolomeo; Gruden, Gabriella; Bruno, Graziella; Amione, Cristina; Fornengo, Paolo; Tassara, Rodolfo; Melis, Deborah; Rebella, Lara; Delitala, Giuseppe; Pretti, Vincenzo; Masala, Maristella Salvatora; Pes, Chiara; Bolondi, Luigi; Rasciti, Leonardo; Serio, Ilaria; Fanelli, Filippo Rossi; Amoroso, Antonio; Molfino, Alessio; Petrillo, Enrico; Zuccalà, Giuseppe; Franceschi, Francesco; De Marco, Guido; Chiara, Cordischi; Marta, Sabbatini; D’Aurizio, Gabriella; Romanelli, Giuseppe; Amolini, Claudia; Chiesa, Deborah; Picardi, Antonio; Gentilucci, Umberto Vespasiani; Gallo, Paolo; Annoni, Giorgio; Corsi, Maurizio; Zazzetta, Sara; Bellelli, Giuseppe; Szabo, Hajnalka; Arturi, Franco; Succurro, Elena; Rubino, Mariangela; Sesti, Giorgio; Loria, Paola; Becchi, Maria Angela; Martucci, Gianfranco; Fantuzzi, Alessandra; Maurantonio, Mauro; Serra, Maria Grazia; Bleve, Maria Antonietta; Gasbarrone, Laura; Sajeva, Maria Rosaria; Brucato, Antonio; Ghidoni, Silvia; Di Corato, Paola; Agnelli, Giancarlo; Marchesini, Emanuela; Fabris, Fabrizio; Carlon, Michela; Turatto, Francesca; Baritusso, Aldo; Amabile, Annalisa; Omenetto, Elisabetta; Scarinzi, Paolo; Manfredini, Roberto; Molino, Christian; Pala, Marco; Fabbian, Fabio; Boari, Benedetta; De Giorgi, Alfredo; Paolisso, Giuseppe; Rizzo, Maria Rosaria; Laieta, Maria Teresa; Rini, Giovanbattista; Mansueto, Pasquale; Pepe, Ilenia; Borghi, Claudio; Strocchi, Enrico; De Sando, Valeria; Pareo, Ilaria; Sabbà, Carlo; Vella, Francesco Saverio; Suppressa, Patrizia; Valerio, Raffaella; Agosti, Pasquale; Fontana, Flavia; Loparco, Francesca; Capobianco, Caterina; Fenoglio, Luigi; Bracco, Christian; Giraudo, Alessia Valentina; Testa, Elisa; Serraino, Cristina; Fargion, Silvia; Bonara, Paola; Periti, Giulia; Porzio, Marianna; Tiraboschi, Slivia; Peyvandi, Flora; Tedeschi, Alberto; Rossio, Raffaella; Ferrari, Barbara; Monzani, Valter; Savojardo, Valeria; Folli, Christian; Salerno, Maria Magnini Francesco; Conca, Alessio; Gobbo, Giulia; Pallini, Giada; Valenti, Miriam; Balduini, Carlo L.; Bertolino, Giampiera; Provini, Stella; Quaglia, Federica; Dallegri, Franco; Ottonello, Luciano; Liberale, Luca; Chin, Wu Sheng; Carassale, Laura; Caporotundo, Silvia; Traisci, Giancarlo; De Feudis, Lucrezia; Di Carlo, Silvia; Liberato, Nicola Lucio; Buratti, Alberto; Tognin, Tiziana; Bianchi, Giovanni Battista; Giaquinto, Sabrina; Purrello, Francesco; Di Pino, Antonino; Piro, Salvatore; Rozzini, Renzo; Falanga, Lina; Spazzini, Elena; Montrucchio, Giuseppe; Greco, Elisabetta; Tizzani, Pietro; Petitti, Paolo; Perciccante, Antonio; Coralli, Alessia; Salmi, Raffaella; Gaudenzi, Piergiorgio; Gamberini, Susanna; Semplicini, Andrea; Gottardo, Lucia; Vendemiale, Gianluigi; Serviddio, Gaetano; Forlano, Roberta; Masala, Cesare; Mammarella, Antonio; Raparelli, Valeria; Basili, Stefania; Perri, Ludovica; Landolfi, Raffaele; Montalto, Massimo; Mirijello, Antonio; Vallone, Carla; Bellusci, Martino; Setti, Donatella; Pedrazzoli, Filippo; Guasti, Luigina; Castiglioni, Luana; Maresca, Andrea; Squizzato, Alessandro; Molaro, Marta; Pellegrini, Elisa; Veltri, Francesca; Sciacqua, Angela; Quero, Michele; Bagnato, Chiara; Colangelo, Lidia; Falbo, Tania; De Giorgio, Roberto; Serra, Mauro; Grasso, Valentina; Ruggeri, Eugenio; Ilaria, Benzoni; Salvi, Andrea; Leonardi, Roberto; Grassini, Chiara; Mascherona, Ilenia; Minelli, Giorgio; Maltese, Francesca; Damiani, Giampaolo; Capeci, William; Mattioli, Massimo; Martino, Giuseppe Pio; Biondi, Lorenzo; Ormas, Monica; Pettinari, Pietro; Romiti, Roberto; Messina, Silvia; Cavallaro, Federica; Ghio, Riccardi; Favorini, Serena; Col, Anna Dal; Minisola, Salvatore; Colangelo, Luciano; Afeltra, Antonella; Alemanno, Pamela; Marigliano, Benedetta; Pipita, Maria Elena; Castellino, Pietro; Blanco, Julien; Zanoli, Luca; Cattaneo, Marco; Fracasso, Paola; Amoruso, Maria Valentina; Saracco, Valter; Fogliati, Marisa; Bussolino, Carlo; Durante, Vittorio; Eusebi, Giovanna; Tirotta, Daniela; Mete, Francesca; Gino, Miriam; Cittadini, Antonio; Vigorito, Carlo; Arcopinto, Michele; Salzano, Andrea; Bobbio, Emanuele; Marra, Alberto Maria; Sirico, Domenico; Moreo, Guido; Scopelliti, Francesco; Gasparini, Francesca; Cocca, Melissa; Ballestrero, Alberto; Ferrando, Fabio; Berra, Sergio; Dassi, Simonetta; Nava, Maria Cristina; Graziella, Bruno; Baldassarre, Stefano; Fragapani, Salvatore; Galanti, Giorgio; Mascherini, Gabriele; Petri, Cristian; Stefani, Laura; Girino, Margherita; Piccinelli, Valeria; Nasso, Francesco; Gioffrè, Vincenza; Pasquale, Maria; Scattolin, Giuseppe; Martinelli, Sergio; Turrin, Mauro; Sechi, Leonardo; Catena, Cristina; Colussi, Gianluca; Nieves, Ramirez Duque; Alberto, Muela Molinero; Pedro, Abad Requejo; Vanessa, Lopez Pelaez; Lara, Tamargo; Xavier, Corbella Viros; Francesc, Formiga; Jesus, Diez Manglano; Esperanza, Bejarano Tello; Esther, Del Corral Behamonte; Maria, Sevil Puras; Romero, Manuel; Blanca, Pinilla Llorente; Cristina, Lopez Gonzalez Cobos; Victoria, Villalba Garcia M.; Saez, Lopez; Bosco, Juan; Susana, Sanz Baena; Marta, Arroyo Gallego; Concepcion, Gonzalez Becerra; Antonio, Fernandez Moyano; Hernandez, Mercedes Gomez; Borrego, Manuel Poyato; Raquel, Pacheco Cuadros; Florencia, Perez Rojas; Beatriz, Garcia Olid; Sara, Carrascosa Garcia; Alfonso, Gonzalez Cruz Cervellera; Marta, Peinado Martinez; Garcia, Sara Carrascosa; Alberto, Ruiz Cantero; Antonio, Albarracín Arraigosa; Montserrat, Godoy Guerrero; Ángel, Barón Ramos Miguel; Manuel, Machin Jose; Ignacio, Novo Veleiro; Lucía, Alvela Suarez; Alfonso, Lopez; David, Rubal Bran; Iria, Iñiguez Vazquez; Monica, Rios Prego.

In: Drugs and Aging, Vol. 34, No. 4, 01.04.2017, p. 311-319.

Research output: Contribution to journalArticle

Bertolotti, M, Franchi, C, Rocchi, MBL, Miceli, A, Libbra, MV, Nobili, A, Lancellotti, G, Carulli, L, Mussi, C, Mannucci, PM, Tettamanti, M, Pasina, L, Perticone, F, Salerno, F, Corrao, S, Marengoni, A, Licata, G, Violi, F, Corazza, GR, Marcucci, M, Eldin, TK, Di Blanca, MPD, Lanzo, G, Astuto, S, Ardoino, I, Cortesi, L, Prisco, D, Silvestri, E, Cenci, C, Emmi, G, Biolo, G, Guarnieri, G, Zanetti, M, Fernandes, G, Chiuch, M, Vanoli, M, Grignani, G, Casella, G, Pulixi, EA, Bernardi, M, Bassi, SL, Santi, L, Zaccherini, G, Mannarino, E, Lupattelli, G, Bianconi, V, Paciullo, F, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Salvatore, T, Sasso, FC, Girelli, D, Olivieri, O, Matteazzi, T, Barbagallo, M, Plances, L, Alcamo, R, Calvo, L, Valenti, M, Pasini, FL, Capecchi, PL, Bicchi, M, Palasciano, G, Modeo, ME, Peragine, M, Pappagallo, F, Pugliese, S, Di Gennaro, C, Postiglione, A, Barbella, MR, De Stefano, F, Cappellini, MD, Fabio, G, Seghezzi, S, De Amicis, MM, Mancarella, M, Mari, D, Rossi, PD, Damanti, S, Ottolini, BB, Bonini, G, Miceli, E, Lenti, MV, Padula, D, Murialdo, G, Marra, A, Cattaneo, F, Secchi, MB, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Davì, G, Guagnano, MT, Sestili, S, Mancuso, G, Calipari, D, Bartone, M, Meroni, MR, Perin, PC, Lorenzati, B, Gruden, G, Bruno, G, Amione, C, Fornengo, P, Tassara, R, Melis, D, Rebella, L, Delitala, G, Pretti, V, Masala, MS, Pes, C, Bolondi, L, Rasciti, L, Serio, I, Fanelli, FR, Amoroso, A, Molfino, A, Petrillo, E, Zuccalà, G, Franceschi, F, De Marco, G, Chiara, C, Marta, S, D’Aurizio, G, Romanelli, G, Amolini, C, Chiesa, D, Picardi, A, Gentilucci, UV, Gallo, P, Annoni, G, Corsi, M, Zazzetta, S, Bellelli, G, Szabo, H, Arturi, F, Succurro, E, Rubino, M, Sesti, G, Loria, P, Becchi, MA, Martucci, G, Fantuzzi, A, Maurantonio, M, Serra, MG, Bleve, MA, Gasbarrone, L, Sajeva, MR, Brucato, A, Ghidoni, S, Di Corato, P, Agnelli, G, Marchesini, E, Fabris, F, Carlon, M, Turatto, F, Baritusso, A, Amabile, A, Omenetto, E, Scarinzi, P, Manfredini, R, Molino, C, Pala, M, Fabbian, F, Boari, B, De Giorgi, A, Paolisso, G, Rizzo, MR, Laieta, MT, Rini, G, Mansueto, P, Pepe, I, Borghi, C, Strocchi, E, De Sando, V, Pareo, I, Sabbà, C, Vella, FS, Suppressa, P, Valerio, R, Agosti, P, Fontana, F, Loparco, F, Capobianco, C, Fenoglio, L, Bracco, C, Giraudo, AV, Testa, E, Serraino, C, Fargion, S, Bonara, P, Periti, G, Porzio, M, Tiraboschi, S, Peyvandi, F, Tedeschi, A, Rossio, R, Ferrari, B, Monzani, V, Savojardo, V, Folli, C, Salerno, MMF, Conca, A, Gobbo, G, Pallini, G, Valenti, M, Balduini, CL, Bertolino, G, Provini, S, Quaglia, F, Dallegri, F, Ottonello, L, Liberale, L, Chin, WS, Carassale, L, Caporotundo, S, Traisci, G, De Feudis, L, Di Carlo, S, Liberato, NL, Buratti, A, Tognin, T, Bianchi, GB, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Montrucchio, G, Greco, E, Tizzani, P, Petitti, P, Perciccante, A, Coralli, A, Salmi, R, Gaudenzi, P, Gamberini, S, Semplicini, A, Gottardo, L, Vendemiale, G, Serviddio, G, Forlano, R, Masala, C, Mammarella, A, Raparelli, V, Basili, S, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Vallone, C, Bellusci, M, Setti, D, Pedrazzoli, F, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Molaro, M, Pellegrini, E, Veltri, F, Sciacqua, A, Quero, M, Bagnato, C, Colangelo, L, Falbo, T, De Giorgio, R, Serra, M, Grasso, V, Ruggeri, E, Ilaria, B, Salvi, A, Leonardi, R, Grassini, C, Mascherona, I, Minelli, G, Maltese, F, Damiani, G, Capeci, W, Mattioli, M, Martino, GP, Biondi, L, Ormas, M, Pettinari, P, Romiti, R, Messina, S, Cavallaro, F, Ghio, R, Favorini, S, Col, AD, Minisola, S, Colangelo, L, Afeltra, A, Alemanno, P, Marigliano, B, Pipita, ME, Castellino, P, Blanco, J, Zanoli, L, Cattaneo, M, Fracasso, P, Amoruso, MV, Saracco, V, Fogliati, M, Bussolino, C, Durante, V, Eusebi, G, Tirotta, D, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Marra, AM, Sirico, D, Moreo, G, Scopelliti, F, Gasparini, F, Cocca, M, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, MC, Graziella, B, Baldassarre, S, Fragapani, S, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffrè, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Nieves, RD, Alberto, MM, Pedro, AR, Vanessa, LP, Lara, T, Xavier, CV, Francesc, F, Jesus, DM, Esperanza, BT, Esther, DCB, Maria, SP, Romero, M, Blanca, PL, Cristina, LGC, Victoria, VGM, Saez, L, Bosco, J, Susana, SB, Marta, AG, Concepcion, GB, Antonio, FM, Hernandez, MG, Borrego, MP, Raquel, PC, Florencia, PR, Beatriz, GO, Sara, CG, Alfonso, GCC, Marta, PM, Garcia, SC, Alberto, RC, Antonio, AA, Montserrat, GG, Ángel, BRM, Manuel, MJ, Ignacio, NV, Lucía, AS, Alfonso, L, David, RB, Iria, IV & Monica, RP 2017, 'Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients: the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study', Drugs and Aging, vol. 34, no. 4, pp. 311-319. https://doi.org/10.1007/s40266-017-0448-8
Bertolotti, Marco ; Franchi, Carlotta ; Rocchi, Marco B.L. ; Miceli, Andrea ; Libbra, M. Vittoria ; Nobili, Alessandro ; Lancellotti, Giulia ; Carulli, Lucia ; Mussi, Chiara ; Mannucci, Pier Mannuccio ; Tettamanti, Mauro ; Pasina, Luca ; Perticone, Francesco ; Salerno, Francesco ; Corrao, Salvatore ; Marengoni, Alessandra ; Licata, Giuseppe ; Violi, Francesco ; Corazza, Gino Roberto ; Marcucci, Maura ; Eldin, Tarek Kamal ; Di Blanca, Maria Pia Donatella ; Lanzo, Giovanna ; Astuto, Sarah ; Ardoino, Ilaria ; Cortesi, Laura ; Prisco, Domenico ; Silvestri, Elena ; Cenci, Caterina ; Emmi, Giacomo ; Biolo, Gianni ; Guarnieri, Gianfranco ; Zanetti, Michela ; Fernandes, Giovanni ; Chiuch, Massimiliano ; Vanoli, Massimo ; Grignani, Giulia ; Casella, Gianluca ; Pulixi, Edoardo Alessandro ; Bernardi, Mauro ; Bassi, Silvia Li ; Santi, Luca ; Zaccherini, Giacomo ; Mannarino, Elmo ; Lupattelli, Graziana ; Bianconi, Vanessa ; Paciullo, Francesco ; Nuti, Ranuccio ; Valenti, Roberto ; Ruvio, Martina ; Cappelli, Silvia ; Palazzuoli, Alberto ; Salvatore, Teresa ; Sasso, Ferdinando Carlo ; Girelli, Domenico ; Olivieri, Oliviero ; Matteazzi, Thomas ; Barbagallo, Mario ; Plances, Lidia ; Alcamo, Roberta ; Calvo, Luigi ; Valenti, Maria ; Pasini, Franco Laghi ; Capecchi, Pier Leopoldo ; Bicchi, Maurizio ; Palasciano, Giuseppe ; Modeo, Maria Ester ; Peragine, Maria ; Pappagallo, Fabrizio ; Pugliese, Stefania ; Di Gennaro, Carla ; Postiglione, Alfredo ; Barbella, Maria Rosaria ; De Stefano, Francesco ; Cappellini, Maria Domenica ; Fabio, Giovanna ; Seghezzi, Sonia ; De Amicis, Margherita Migone ; Mancarella, Marta ; Mari, Daniela ; Rossi, Paolo Dionigi ; Damanti, Sarah ; Ottolini, Barbara Brignolo ; Bonini, Giulia ; Miceli, Emanuela ; Lenti, Marco Vincenzo ; Padula, Donatella ; Murialdo, Giovanni ; Marra, Alessio ; Cattaneo, Federico ; Secchi, Maria Beatrice ; Ghelfi, Davide ; Anastasio, Luigi ; Sofia, Lucia ; Carbone, Maria ; Davì, Giovanni ; Guagnano, Maria Teresa ; Sestili, Simona ; Mancuso, Gerardo ; Calipari, Daniela ; Bartone, Mosè ; Meroni, Maria Rachele ; Perin, Paolo Cavallo ; Lorenzati, Bartolomeo ; Gruden, Gabriella ; Bruno, Graziella ; Amione, Cristina ; Fornengo, Paolo ; Tassara, Rodolfo ; Melis, Deborah ; Rebella, Lara ; Delitala, Giuseppe ; Pretti, Vincenzo ; Masala, Maristella Salvatora ; Pes, Chiara ; Bolondi, Luigi ; Rasciti, Leonardo ; Serio, Ilaria ; Fanelli, Filippo Rossi ; Amoroso, Antonio ; Molfino, Alessio ; Petrillo, Enrico ; Zuccalà, Giuseppe ; Franceschi, Francesco ; De Marco, Guido ; Chiara, Cordischi ; Marta, Sabbatini ; D’Aurizio, Gabriella ; Romanelli, Giuseppe ; Amolini, Claudia ; Chiesa, Deborah ; Picardi, Antonio ; Gentilucci, Umberto Vespasiani ; Gallo, Paolo ; Annoni, Giorgio ; Corsi, Maurizio ; Zazzetta, Sara ; Bellelli, Giuseppe ; Szabo, Hajnalka ; Arturi, Franco ; Succurro, Elena ; Rubino, Mariangela ; Sesti, Giorgio ; Loria, Paola ; Becchi, Maria Angela ; Martucci, Gianfranco ; Fantuzzi, Alessandra ; Maurantonio, Mauro ; Serra, Maria Grazia ; Bleve, Maria Antonietta ; Gasbarrone, Laura ; Sajeva, Maria Rosaria ; Brucato, Antonio ; Ghidoni, Silvia ; Di Corato, Paola ; Agnelli, Giancarlo ; Marchesini, Emanuela ; Fabris, Fabrizio ; Carlon, Michela ; Turatto, Francesca ; Baritusso, Aldo ; Amabile, Annalisa ; Omenetto, Elisabetta ; Scarinzi, Paolo ; Manfredini, Roberto ; Molino, Christian ; Pala, Marco ; Fabbian, Fabio ; Boari, Benedetta ; De Giorgi, Alfredo ; Paolisso, Giuseppe ; Rizzo, Maria Rosaria ; Laieta, Maria Teresa ; Rini, Giovanbattista ; Mansueto, Pasquale ; Pepe, Ilenia ; Borghi, Claudio ; Strocchi, Enrico ; De Sando, Valeria ; Pareo, Ilaria ; Sabbà, Carlo ; Vella, Francesco Saverio ; Suppressa, Patrizia ; Valerio, Raffaella ; Agosti, Pasquale ; Fontana, Flavia ; Loparco, Francesca ; Capobianco, Caterina ; Fenoglio, Luigi ; Bracco, Christian ; Giraudo, Alessia Valentina ; Testa, Elisa ; Serraino, Cristina ; Fargion, Silvia ; Bonara, Paola ; Periti, Giulia ; Porzio, Marianna ; Tiraboschi, Slivia ; Peyvandi, Flora ; Tedeschi, Alberto ; Rossio, Raffaella ; Ferrari, Barbara ; Monzani, Valter ; Savojardo, Valeria ; Folli, Christian ; Salerno, Maria Magnini Francesco ; Conca, Alessio ; Gobbo, Giulia ; Pallini, Giada ; Valenti, Miriam ; Balduini, Carlo L. ; Bertolino, Giampiera ; Provini, Stella ; Quaglia, Federica ; Dallegri, Franco ; Ottonello, Luciano ; Liberale, Luca ; Chin, Wu Sheng ; Carassale, Laura ; Caporotundo, Silvia ; Traisci, Giancarlo ; De Feudis, Lucrezia ; Di Carlo, Silvia ; Liberato, Nicola Lucio ; Buratti, Alberto ; Tognin, Tiziana ; Bianchi, Giovanni Battista ; Giaquinto, Sabrina ; Purrello, Francesco ; Di Pino, Antonino ; Piro, Salvatore ; Rozzini, Renzo ; Falanga, Lina ; Spazzini, Elena ; Montrucchio, Giuseppe ; Greco, Elisabetta ; Tizzani, Pietro ; Petitti, Paolo ; Perciccante, Antonio ; Coralli, Alessia ; Salmi, Raffaella ; Gaudenzi, Piergiorgio ; Gamberini, Susanna ; Semplicini, Andrea ; Gottardo, Lucia ; Vendemiale, Gianluigi ; Serviddio, Gaetano ; Forlano, Roberta ; Masala, Cesare ; Mammarella, Antonio ; Raparelli, Valeria ; Basili, Stefania ; Perri, Ludovica ; Landolfi, Raffaele ; Montalto, Massimo ; Mirijello, Antonio ; Vallone, Carla ; Bellusci, Martino ; Setti, Donatella ; Pedrazzoli, Filippo ; Guasti, Luigina ; Castiglioni, Luana ; Maresca, Andrea ; Squizzato, Alessandro ; Molaro, Marta ; Pellegrini, Elisa ; Veltri, Francesca ; Sciacqua, Angela ; Quero, Michele ; Bagnato, Chiara ; Colangelo, Lidia ; Falbo, Tania ; De Giorgio, Roberto ; Serra, Mauro ; Grasso, Valentina ; Ruggeri, Eugenio ; Ilaria, Benzoni ; Salvi, Andrea ; Leonardi, Roberto ; Grassini, Chiara ; Mascherona, Ilenia ; Minelli, Giorgio ; Maltese, Francesca ; Damiani, Giampaolo ; Capeci, William ; Mattioli, Massimo ; Martino, Giuseppe Pio ; Biondi, Lorenzo ; Ormas, Monica ; Pettinari, Pietro ; Romiti, Roberto ; Messina, Silvia ; Cavallaro, Federica ; Ghio, Riccardi ; Favorini, Serena ; Col, Anna Dal ; Minisola, Salvatore ; Colangelo, Luciano ; Afeltra, Antonella ; Alemanno, Pamela ; Marigliano, Benedetta ; Pipita, Maria Elena ; Castellino, Pietro ; Blanco, Julien ; Zanoli, Luca ; Cattaneo, Marco ; Fracasso, Paola ; Amoruso, Maria Valentina ; Saracco, Valter ; Fogliati, Marisa ; Bussolino, Carlo ; Durante, Vittorio ; Eusebi, Giovanna ; Tirotta, Daniela ; Mete, Francesca ; Gino, Miriam ; Cittadini, Antonio ; Vigorito, Carlo ; Arcopinto, Michele ; Salzano, Andrea ; Bobbio, Emanuele ; Marra, Alberto Maria ; Sirico, Domenico ; Moreo, Guido ; Scopelliti, Francesco ; Gasparini, Francesca ; Cocca, Melissa ; Ballestrero, Alberto ; Ferrando, Fabio ; Berra, Sergio ; Dassi, Simonetta ; Nava, Maria Cristina ; Graziella, Bruno ; Baldassarre, Stefano ; Fragapani, Salvatore ; Galanti, Giorgio ; Mascherini, Gabriele ; Petri, Cristian ; Stefani, Laura ; Girino, Margherita ; Piccinelli, Valeria ; Nasso, Francesco ; Gioffrè, Vincenza ; Pasquale, Maria ; Scattolin, Giuseppe ; Martinelli, Sergio ; Turrin, Mauro ; Sechi, Leonardo ; Catena, Cristina ; Colussi, Gianluca ; Nieves, Ramirez Duque ; Alberto, Muela Molinero ; Pedro, Abad Requejo ; Vanessa, Lopez Pelaez ; Lara, Tamargo ; Xavier, Corbella Viros ; Francesc, Formiga ; Jesus, Diez Manglano ; Esperanza, Bejarano Tello ; Esther, Del Corral Behamonte ; Maria, Sevil Puras ; Romero, Manuel ; Blanca, Pinilla Llorente ; Cristina, Lopez Gonzalez Cobos ; Victoria, Villalba Garcia M. ; Saez, Lopez ; Bosco, Juan ; Susana, Sanz Baena ; Marta, Arroyo Gallego ; Concepcion, Gonzalez Becerra ; Antonio, Fernandez Moyano ; Hernandez, Mercedes Gomez ; Borrego, Manuel Poyato ; Raquel, Pacheco Cuadros ; Florencia, Perez Rojas ; Beatriz, Garcia Olid ; Sara, Carrascosa Garcia ; Alfonso, Gonzalez Cruz Cervellera ; Marta, Peinado Martinez ; Garcia, Sara Carrascosa ; Alberto, Ruiz Cantero ; Antonio, Albarracín Arraigosa ; Montserrat, Godoy Guerrero ; Ángel, Barón Ramos Miguel ; Manuel, Machin Jose ; Ignacio, Novo Veleiro ; Lucía, Alvela Suarez ; Alfonso, Lopez ; David, Rubal Bran ; Iria, Iñiguez Vazquez ; Monica, Rios Prego. / Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients : the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study. In: Drugs and Aging. 2017 ; Vol. 34, No. 4. pp. 311-319.
@article{3dcfc5cfa14a4e5f939fcd90daf1d0aa,
title = "Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients: the Findings from the REPOSI (REgistro POliterapie Societ{\`a} Italiana di Medicina Interna) Study",
abstract = "Background: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. Aim: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. Methods: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Societ{\`a} Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical profiles, including multimorbidity markers and polypharmacy. Results: 2171 patients aged >65 years were enrolled (1057 males, 1114 females, mean age 78.6 years). The patients treated with lipid-lowering drugs amounted to 508 subjects (23.4{\%}), with no gender difference. Atorvastatin (39.3{\%}) and simvastatin (34.0{\%}) were the most widely used statin drugs. Likelihood of treatment was associated with polypharmacy (≥5 drugs) and with higher Cumulative Illness Rating Scale (CIRS) score. At logistic regression analysis, the presence of coronary heart disease, peripheral vascular disease, and hypertension were significantly correlated with lipid-lowering drug use, whereas age showed an inverse correlation. Diabetes was not associated with drug treatment. Conclusions: In this in-hospital cohort, the use of lipid-lowering agents was mainly driven by patients’ clinical history, most notably the presence of clinically overt manifestations of atherosclerosis. Increasing age seems to be associated with lower prescription rates. This might be indicative of cautious behavior towards a potentially toxic treatment regimen.",
author = "Marco Bertolotti and Carlotta Franchi and Rocchi, {Marco B.L.} and Andrea Miceli and Libbra, {M. Vittoria} and Alessandro Nobili and Giulia Lancellotti and Lucia Carulli and Chiara Mussi and Mannucci, {Pier Mannuccio} and Mauro Tettamanti and Luca Pasina and Francesco Perticone and Francesco Salerno and Salvatore Corrao and Alessandra Marengoni and Giuseppe Licata and Francesco Violi and Corazza, {Gino Roberto} and Maura Marcucci and Eldin, {Tarek Kamal} and {Di Blanca}, {Maria Pia Donatella} and Giovanna Lanzo and Sarah Astuto and Ilaria Ardoino and Laura Cortesi and Domenico Prisco and Elena Silvestri and Caterina Cenci and Giacomo Emmi and Gianni Biolo and Gianfranco Guarnieri and Michela Zanetti and Giovanni Fernandes and Massimiliano Chiuch and Massimo Vanoli and Giulia Grignani and Gianluca Casella and Pulixi, {Edoardo Alessandro} and Mauro Bernardi and Bassi, {Silvia Li} and Luca Santi and Giacomo Zaccherini and Elmo Mannarino and Graziana Lupattelli and Vanessa Bianconi and Francesco Paciullo and Ranuccio Nuti and Roberto Valenti and Martina Ruvio and Silvia Cappelli and Alberto Palazzuoli and Teresa Salvatore and Sasso, {Ferdinando Carlo} and Domenico Girelli and Oliviero Olivieri and Thomas Matteazzi and Mario Barbagallo and Lidia Plances and Roberta Alcamo and Luigi Calvo and Maria Valenti and Pasini, {Franco Laghi} and Capecchi, {Pier Leopoldo} and Maurizio Bicchi and Giuseppe Palasciano and Modeo, {Maria Ester} and Maria Peragine and Fabrizio Pappagallo and Stefania Pugliese and {Di Gennaro}, Carla and Alfredo Postiglione and Barbella, {Maria Rosaria} and {De Stefano}, Francesco and Cappellini, {Maria Domenica} and Giovanna Fabio and Sonia Seghezzi and {De Amicis}, {Margherita Migone} and Marta Mancarella and Daniela Mari and Rossi, {Paolo Dionigi} and Sarah Damanti and Ottolini, {Barbara Brignolo} and Giulia Bonini and Emanuela Miceli and Lenti, {Marco Vincenzo} and Donatella Padula and Giovanni Murialdo and Alessio Marra and Federico Cattaneo and Secchi, {Maria Beatrice} and Davide Ghelfi and Luigi Anastasio and Lucia Sofia and Maria Carbone and Giovanni Dav{\`i} and Guagnano, {Maria Teresa} and Simona Sestili and Gerardo Mancuso and Daniela Calipari and Mos{\`e} Bartone and Meroni, {Maria Rachele} and Perin, {Paolo Cavallo} and Bartolomeo Lorenzati and Gabriella Gruden and Graziella Bruno and Cristina Amione and Paolo Fornengo and Rodolfo Tassara and Deborah Melis and Lara Rebella and Giuseppe Delitala and Vincenzo Pretti and Masala, {Maristella Salvatora} and Chiara Pes and Luigi Bolondi and Leonardo Rasciti and Ilaria Serio and Fanelli, {Filippo Rossi} and Antonio Amoroso and Alessio Molfino and Enrico Petrillo and Giuseppe Zuccal{\`a} and Francesco Franceschi and {De Marco}, Guido and Cordischi Chiara and Sabbatini Marta and Gabriella D’Aurizio and Giuseppe Romanelli and Claudia Amolini and Deborah Chiesa and Antonio Picardi and Gentilucci, {Umberto Vespasiani} and Paolo Gallo and Giorgio Annoni and Maurizio Corsi and Sara Zazzetta and Giuseppe Bellelli and Hajnalka Szabo and Franco Arturi and Elena Succurro and Mariangela Rubino and Giorgio Sesti and Paola Loria and Becchi, {Maria Angela} and Gianfranco Martucci and Alessandra Fantuzzi and Mauro Maurantonio and Serra, {Maria Grazia} and Bleve, {Maria Antonietta} and Laura Gasbarrone and Sajeva, {Maria Rosaria} and Antonio Brucato and Silvia Ghidoni and {Di Corato}, Paola and Giancarlo Agnelli and Emanuela Marchesini and Fabrizio Fabris and Michela Carlon and Francesca Turatto and Aldo Baritusso and Annalisa Amabile and Elisabetta Omenetto and Paolo Scarinzi and Roberto Manfredini and Christian Molino and Marco Pala and Fabio Fabbian and Benedetta Boari and {De Giorgi}, Alfredo and Giuseppe Paolisso and Rizzo, {Maria Rosaria} and Laieta, {Maria Teresa} and Giovanbattista Rini and Pasquale Mansueto and Ilenia Pepe and Claudio Borghi and Enrico Strocchi and {De Sando}, Valeria and Ilaria Pareo and Carlo Sabb{\`a} and Vella, {Francesco Saverio} and Patrizia Suppressa and Raffaella Valerio and Pasquale Agosti and Flavia Fontana and Francesca Loparco and Caterina Capobianco and Luigi Fenoglio and Christian Bracco and Giraudo, {Alessia Valentina} and Elisa Testa and Cristina Serraino and Silvia Fargion and Paola Bonara and Giulia Periti and Marianna Porzio and Slivia Tiraboschi and Flora Peyvandi and Alberto Tedeschi and Raffaella Rossio and Barbara Ferrari and Valter Monzani and Valeria Savojardo and Christian Folli and Salerno, {Maria Magnini Francesco} and Alessio Conca and Giulia Gobbo and Giada Pallini and Miriam Valenti and Balduini, {Carlo L.} and Giampiera Bertolino and Stella Provini and Federica Quaglia and Franco Dallegri and Luciano Ottonello and Luca Liberale and Chin, {Wu Sheng} and Laura Carassale and Silvia Caporotundo and Giancarlo Traisci and {De Feudis}, Lucrezia and {Di Carlo}, Silvia and Liberato, {Nicola Lucio} and Alberto Buratti and Tiziana Tognin and Bianchi, {Giovanni Battista} and Sabrina Giaquinto and Francesco Purrello and {Di Pino}, Antonino and Salvatore Piro and Renzo Rozzini and Lina Falanga and Elena Spazzini and Giuseppe Montrucchio and Elisabetta Greco and Pietro Tizzani and Paolo Petitti and Antonio Perciccante and Alessia Coralli and Raffaella Salmi and Piergiorgio Gaudenzi and Susanna Gamberini and Andrea Semplicini and Lucia Gottardo and Gianluigi Vendemiale and Gaetano Serviddio and Roberta Forlano and Cesare Masala and Antonio Mammarella and Valeria Raparelli and Stefania Basili and Ludovica Perri and Raffaele Landolfi and Massimo Montalto and Antonio Mirijello and Carla Vallone and Martino Bellusci and Donatella Setti and Filippo Pedrazzoli and Luigina Guasti and Luana Castiglioni and Andrea Maresca and Alessandro Squizzato and Marta Molaro and Elisa Pellegrini and Francesca Veltri and Angela Sciacqua and Michele Quero and Chiara Bagnato and Lidia Colangelo and Tania Falbo and {De Giorgio}, Roberto and Mauro Serra and Valentina Grasso and Eugenio Ruggeri and Benzoni Ilaria and Andrea Salvi and Roberto Leonardi and Chiara Grassini and Ilenia Mascherona and Giorgio Minelli and Francesca Maltese and Giampaolo Damiani and William Capeci and Massimo Mattioli and Martino, {Giuseppe Pio} and Lorenzo Biondi and Monica Ormas and Pietro Pettinari and Roberto Romiti and Silvia Messina and Federica Cavallaro and Riccardi Ghio and Serena Favorini and Col, {Anna Dal} and Salvatore Minisola and Luciano Colangelo and Antonella Afeltra and Pamela Alemanno and Benedetta Marigliano and Pipita, {Maria Elena} and Pietro Castellino and Julien Blanco and Luca Zanoli and Marco Cattaneo and Paola Fracasso and Amoruso, {Maria Valentina} and Valter Saracco and Marisa Fogliati and Carlo Bussolino and Vittorio Durante and Giovanna Eusebi and Daniela Tirotta and Francesca Mete and Miriam Gino and Antonio Cittadini and Carlo Vigorito and Michele Arcopinto and Andrea Salzano and Emanuele Bobbio and Marra, {Alberto Maria} and Domenico Sirico and Guido Moreo and Francesco Scopelliti and Francesca Gasparini and Melissa Cocca and Alberto Ballestrero and Fabio Ferrando and Sergio Berra and Simonetta Dassi and Nava, {Maria Cristina} and Bruno Graziella and Stefano Baldassarre and Salvatore Fragapani and Giorgio Galanti and Gabriele Mascherini and Cristian Petri and Laura Stefani and Margherita Girino and Valeria Piccinelli and Francesco Nasso and Vincenza Gioffr{\`e} and Maria Pasquale and Giuseppe Scattolin and Sergio Martinelli and Mauro Turrin and Leonardo Sechi and Cristina Catena and Gianluca Colussi and Nieves, {Ramirez Duque} and Alberto, {Muela Molinero} and Pedro, {Abad Requejo} and Vanessa, {Lopez Pelaez} and Tamargo Lara and Xavier, {Corbella Viros} and Formiga Francesc and Jesus, {Diez Manglano} and Esperanza, {Bejarano Tello} and Esther, {Del Corral Behamonte} and Maria, {Sevil Puras} and Manuel Romero and Blanca, {Pinilla Llorente} and Cristina, {Lopez Gonzalez Cobos} and Victoria, {Villalba Garcia M.} and Lopez Saez and Juan Bosco and Susana, {Sanz Baena} and Marta, {Arroyo Gallego} and Concepcion, {Gonzalez Becerra} and Antonio, {Fernandez Moyano} and Hernandez, {Mercedes Gomez} and Borrego, {Manuel Poyato} and Raquel, {Pacheco Cuadros} and Florencia, {Perez Rojas} and Beatriz, {Garcia Olid} and Sara, {Carrascosa Garcia} and Alfonso, {Gonzalez Cruz Cervellera} and Marta, {Peinado Martinez} and Garcia, {Sara Carrascosa} and Alberto, {Ruiz Cantero} and Antonio, {Albarrac{\'i}n Arraigosa} and Montserrat, {Godoy Guerrero} and {\'A}ngel, {Bar{\'o}n Ramos Miguel} and Manuel, {Machin Jose} and Ignacio, {Novo Veleiro} and Luc{\'i}a, {Alvela Suarez} and Lopez Alfonso and David, {Rubal Bran} and Iria, {I{\~n}iguez Vazquez} and Monica, {Rios Prego}",
year = "2017",
month = "4",
day = "1",
doi = "10.1007/s40266-017-0448-8",
language = "English",
volume = "34",
pages = "311--319",
journal = "Drugs and Aging",
issn = "1170-229X",
publisher = "Springer International Publishing",
number = "4",

}

TY - JOUR

T1 - Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients

T2 - the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study

AU - Bertolotti, Marco

AU - Franchi, Carlotta

AU - Rocchi, Marco B.L.

AU - Miceli, Andrea

AU - Libbra, M. Vittoria

AU - Nobili, Alessandro

AU - Lancellotti, Giulia

AU - Carulli, Lucia

AU - Mussi, Chiara

AU - Mannucci, Pier Mannuccio

AU - Tettamanti, Mauro

AU - Pasina, Luca

AU - Perticone, Francesco

AU - Salerno, Francesco

AU - Corrao, Salvatore

AU - Marengoni, Alessandra

AU - Licata, Giuseppe

AU - Violi, Francesco

AU - Corazza, Gino Roberto

AU - Marcucci, Maura

AU - Eldin, Tarek Kamal

AU - Di Blanca, Maria Pia Donatella

AU - Lanzo, Giovanna

AU - Astuto, Sarah

AU - Ardoino, Ilaria

AU - Cortesi, Laura

AU - Prisco, Domenico

AU - Silvestri, Elena

AU - Cenci, Caterina

AU - Emmi, Giacomo

AU - Biolo, Gianni

AU - Guarnieri, Gianfranco

AU - Zanetti, Michela

AU - Fernandes, Giovanni

AU - Chiuch, Massimiliano

AU - Vanoli, Massimo

AU - Grignani, Giulia

AU - Casella, Gianluca

AU - Pulixi, Edoardo Alessandro

AU - Bernardi, Mauro

AU - Bassi, Silvia Li

AU - Santi, Luca

AU - Zaccherini, Giacomo

AU - Mannarino, Elmo

AU - Lupattelli, Graziana

AU - Bianconi, Vanessa

AU - Paciullo, Francesco

AU - Nuti, Ranuccio

AU - Valenti, Roberto

AU - Ruvio, Martina

AU - Cappelli, Silvia

AU - Palazzuoli, Alberto

AU - Salvatore, Teresa

AU - Sasso, Ferdinando Carlo

AU - Girelli, Domenico

AU - Olivieri, Oliviero

AU - Matteazzi, Thomas

AU - Barbagallo, Mario

AU - Plances, Lidia

AU - Alcamo, Roberta

AU - Calvo, Luigi

AU - Valenti, Maria

AU - Pasini, Franco Laghi

AU - Capecchi, Pier Leopoldo

AU - Bicchi, Maurizio

AU - Palasciano, Giuseppe

AU - Modeo, Maria Ester

AU - Peragine, Maria

AU - Pappagallo, Fabrizio

AU - Pugliese, Stefania

AU - Di Gennaro, Carla

AU - Postiglione, Alfredo

AU - Barbella, Maria Rosaria

AU - De Stefano, Francesco

AU - Cappellini, Maria Domenica

AU - Fabio, Giovanna

AU - Seghezzi, Sonia

AU - De Amicis, Margherita Migone

AU - Mancarella, Marta

AU - Mari, Daniela

AU - Rossi, Paolo Dionigi

AU - Damanti, Sarah

AU - Ottolini, Barbara Brignolo

AU - Bonini, Giulia

AU - Miceli, Emanuela

AU - Lenti, Marco Vincenzo

AU - Padula, Donatella

AU - Murialdo, Giovanni

AU - Marra, Alessio

AU - Cattaneo, Federico

AU - Secchi, Maria Beatrice

AU - Ghelfi, Davide

AU - Anastasio, Luigi

AU - Sofia, Lucia

AU - Carbone, Maria

AU - Davì, Giovanni

AU - Guagnano, Maria Teresa

AU - Sestili, Simona

AU - Mancuso, Gerardo

AU - Calipari, Daniela

AU - Bartone, Mosè

AU - Meroni, Maria Rachele

AU - Perin, Paolo Cavallo

AU - Lorenzati, Bartolomeo

AU - Gruden, Gabriella

AU - Bruno, Graziella

AU - Amione, Cristina

AU - Fornengo, Paolo

AU - Tassara, Rodolfo

AU - Melis, Deborah

AU - Rebella, Lara

AU - Delitala, Giuseppe

AU - Pretti, Vincenzo

AU - Masala, Maristella Salvatora

AU - Pes, Chiara

AU - Bolondi, Luigi

AU - Rasciti, Leonardo

AU - Serio, Ilaria

AU - Fanelli, Filippo Rossi

AU - Amoroso, Antonio

AU - Molfino, Alessio

AU - Petrillo, Enrico

AU - Zuccalà, Giuseppe

AU - Franceschi, Francesco

AU - De Marco, Guido

AU - Chiara, Cordischi

AU - Marta, Sabbatini

AU - D’Aurizio, Gabriella

AU - Romanelli, Giuseppe

AU - Amolini, Claudia

AU - Chiesa, Deborah

AU - Picardi, Antonio

AU - Gentilucci, Umberto Vespasiani

AU - Gallo, Paolo

AU - Annoni, Giorgio

AU - Corsi, Maurizio

AU - Zazzetta, Sara

AU - Bellelli, Giuseppe

AU - Szabo, Hajnalka

AU - Arturi, Franco

AU - Succurro, Elena

AU - Rubino, Mariangela

AU - Sesti, Giorgio

AU - Loria, Paola

AU - Becchi, Maria Angela

AU - Martucci, Gianfranco

AU - Fantuzzi, Alessandra

AU - Maurantonio, Mauro

AU - Serra, Maria Grazia

AU - Bleve, Maria Antonietta

AU - Gasbarrone, Laura

AU - Sajeva, Maria Rosaria

AU - Brucato, Antonio

AU - Ghidoni, Silvia

AU - Di Corato, Paola

AU - Agnelli, Giancarlo

AU - Marchesini, Emanuela

AU - Fabris, Fabrizio

AU - Carlon, Michela

AU - Turatto, Francesca

AU - Baritusso, Aldo

AU - Amabile, Annalisa

AU - Omenetto, Elisabetta

AU - Scarinzi, Paolo

AU - Manfredini, Roberto

AU - Molino, Christian

AU - Pala, Marco

AU - Fabbian, Fabio

AU - Boari, Benedetta

AU - De Giorgi, Alfredo

AU - Paolisso, Giuseppe

AU - Rizzo, Maria Rosaria

AU - Laieta, Maria Teresa

AU - Rini, Giovanbattista

AU - Mansueto, Pasquale

AU - Pepe, Ilenia

AU - Borghi, Claudio

AU - Strocchi, Enrico

AU - De Sando, Valeria

AU - Pareo, Ilaria

AU - Sabbà, Carlo

AU - Vella, Francesco Saverio

AU - Suppressa, Patrizia

AU - Valerio, Raffaella

AU - Agosti, Pasquale

AU - Fontana, Flavia

AU - Loparco, Francesca

AU - Capobianco, Caterina

AU - Fenoglio, Luigi

AU - Bracco, Christian

AU - Giraudo, Alessia Valentina

AU - Testa, Elisa

AU - Serraino, Cristina

AU - Fargion, Silvia

AU - Bonara, Paola

AU - Periti, Giulia

AU - Porzio, Marianna

AU - Tiraboschi, Slivia

AU - Peyvandi, Flora

AU - Tedeschi, Alberto

AU - Rossio, Raffaella

AU - Ferrari, Barbara

AU - Monzani, Valter

AU - Savojardo, Valeria

AU - Folli, Christian

AU - Salerno, Maria Magnini Francesco

AU - Conca, Alessio

AU - Gobbo, Giulia

AU - Pallini, Giada

AU - Valenti, Miriam

AU - Balduini, Carlo L.

AU - Bertolino, Giampiera

AU - Provini, Stella

AU - Quaglia, Federica

AU - Dallegri, Franco

AU - Ottonello, Luciano

AU - Liberale, Luca

AU - Chin, Wu Sheng

AU - Carassale, Laura

AU - Caporotundo, Silvia

AU - Traisci, Giancarlo

AU - De Feudis, Lucrezia

AU - Di Carlo, Silvia

AU - Liberato, Nicola Lucio

AU - Buratti, Alberto

AU - Tognin, Tiziana

AU - Bianchi, Giovanni Battista

AU - Giaquinto, Sabrina

AU - Purrello, Francesco

AU - Di Pino, Antonino

AU - Piro, Salvatore

AU - Rozzini, Renzo

AU - Falanga, Lina

AU - Spazzini, Elena

AU - Montrucchio, Giuseppe

AU - Greco, Elisabetta

AU - Tizzani, Pietro

AU - Petitti, Paolo

AU - Perciccante, Antonio

AU - Coralli, Alessia

AU - Salmi, Raffaella

AU - Gaudenzi, Piergiorgio

AU - Gamberini, Susanna

AU - Semplicini, Andrea

AU - Gottardo, Lucia

AU - Vendemiale, Gianluigi

AU - Serviddio, Gaetano

AU - Forlano, Roberta

AU - Masala, Cesare

AU - Mammarella, Antonio

AU - Raparelli, Valeria

AU - Basili, Stefania

AU - Perri, Ludovica

AU - Landolfi, Raffaele

AU - Montalto, Massimo

AU - Mirijello, Antonio

AU - Vallone, Carla

AU - Bellusci, Martino

AU - Setti, Donatella

AU - Pedrazzoli, Filippo

AU - Guasti, Luigina

AU - Castiglioni, Luana

AU - Maresca, Andrea

AU - Squizzato, Alessandro

AU - Molaro, Marta

AU - Pellegrini, Elisa

AU - Veltri, Francesca

AU - Sciacqua, Angela

AU - Quero, Michele

AU - Bagnato, Chiara

AU - Colangelo, Lidia

AU - Falbo, Tania

AU - De Giorgio, Roberto

AU - Serra, Mauro

AU - Grasso, Valentina

AU - Ruggeri, Eugenio

AU - Ilaria, Benzoni

AU - Salvi, Andrea

AU - Leonardi, Roberto

AU - Grassini, Chiara

AU - Mascherona, Ilenia

AU - Minelli, Giorgio

AU - Maltese, Francesca

AU - Damiani, Giampaolo

AU - Capeci, William

AU - Mattioli, Massimo

AU - Martino, Giuseppe Pio

AU - Biondi, Lorenzo

AU - Ormas, Monica

AU - Pettinari, Pietro

AU - Romiti, Roberto

AU - Messina, Silvia

AU - Cavallaro, Federica

AU - Ghio, Riccardi

AU - Favorini, Serena

AU - Col, Anna Dal

AU - Minisola, Salvatore

AU - Colangelo, Luciano

AU - Afeltra, Antonella

AU - Alemanno, Pamela

AU - Marigliano, Benedetta

AU - Pipita, Maria Elena

AU - Castellino, Pietro

AU - Blanco, Julien

AU - Zanoli, Luca

AU - Cattaneo, Marco

AU - Fracasso, Paola

AU - Amoruso, Maria Valentina

AU - Saracco, Valter

AU - Fogliati, Marisa

AU - Bussolino, Carlo

AU - Durante, Vittorio

AU - Eusebi, Giovanna

AU - Tirotta, Daniela

AU - Mete, Francesca

AU - Gino, Miriam

AU - Cittadini, Antonio

AU - Vigorito, Carlo

AU - Arcopinto, Michele

AU - Salzano, Andrea

AU - Bobbio, Emanuele

AU - Marra, Alberto Maria

AU - Sirico, Domenico

AU - Moreo, Guido

AU - Scopelliti, Francesco

AU - Gasparini, Francesca

AU - Cocca, Melissa

AU - Ballestrero, Alberto

AU - Ferrando, Fabio

AU - Berra, Sergio

AU - Dassi, Simonetta

AU - Nava, Maria Cristina

AU - Graziella, Bruno

AU - Baldassarre, Stefano

AU - Fragapani, Salvatore

AU - Galanti, Giorgio

AU - Mascherini, Gabriele

AU - Petri, Cristian

AU - Stefani, Laura

AU - Girino, Margherita

AU - Piccinelli, Valeria

AU - Nasso, Francesco

AU - Gioffrè, Vincenza

AU - Pasquale, Maria

AU - Scattolin, Giuseppe

AU - Martinelli, Sergio

AU - Turrin, Mauro

AU - Sechi, Leonardo

AU - Catena, Cristina

AU - Colussi, Gianluca

AU - Nieves, Ramirez Duque

AU - Alberto, Muela Molinero

AU - Pedro, Abad Requejo

AU - Vanessa, Lopez Pelaez

AU - Lara, Tamargo

AU - Xavier, Corbella Viros

AU - Francesc, Formiga

AU - Jesus, Diez Manglano

AU - Esperanza, Bejarano Tello

AU - Esther, Del Corral Behamonte

AU - Maria, Sevil Puras

AU - Romero, Manuel

AU - Blanca, Pinilla Llorente

AU - Cristina, Lopez Gonzalez Cobos

AU - Victoria, Villalba Garcia M.

AU - Saez, Lopez

AU - Bosco, Juan

AU - Susana, Sanz Baena

AU - Marta, Arroyo Gallego

AU - Concepcion, Gonzalez Becerra

AU - Antonio, Fernandez Moyano

AU - Hernandez, Mercedes Gomez

AU - Borrego, Manuel Poyato

AU - Raquel, Pacheco Cuadros

AU - Florencia, Perez Rojas

AU - Beatriz, Garcia Olid

AU - Sara, Carrascosa Garcia

AU - Alfonso, Gonzalez Cruz Cervellera

AU - Marta, Peinado Martinez

AU - Garcia, Sara Carrascosa

AU - Alberto, Ruiz Cantero

AU - Antonio, Albarracín Arraigosa

AU - Montserrat, Godoy Guerrero

AU - Ángel, Barón Ramos Miguel

AU - Manuel, Machin Jose

AU - Ignacio, Novo Veleiro

AU - Lucía, Alvela Suarez

AU - Alfonso, Lopez

AU - David, Rubal Bran

AU - Iria, Iñiguez Vazquez

AU - Monica, Rios Prego

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. Aim: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. Methods: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical profiles, including multimorbidity markers and polypharmacy. Results: 2171 patients aged >65 years were enrolled (1057 males, 1114 females, mean age 78.6 years). The patients treated with lipid-lowering drugs amounted to 508 subjects (23.4%), with no gender difference. Atorvastatin (39.3%) and simvastatin (34.0%) were the most widely used statin drugs. Likelihood of treatment was associated with polypharmacy (≥5 drugs) and with higher Cumulative Illness Rating Scale (CIRS) score. At logistic regression analysis, the presence of coronary heart disease, peripheral vascular disease, and hypertension were significantly correlated with lipid-lowering drug use, whereas age showed an inverse correlation. Diabetes was not associated with drug treatment. Conclusions: In this in-hospital cohort, the use of lipid-lowering agents was mainly driven by patients’ clinical history, most notably the presence of clinically overt manifestations of atherosclerosis. Increasing age seems to be associated with lower prescription rates. This might be indicative of cautious behavior towards a potentially toxic treatment regimen.

AB - Background: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. Aim: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. Methods: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical profiles, including multimorbidity markers and polypharmacy. Results: 2171 patients aged >65 years were enrolled (1057 males, 1114 females, mean age 78.6 years). The patients treated with lipid-lowering drugs amounted to 508 subjects (23.4%), with no gender difference. Atorvastatin (39.3%) and simvastatin (34.0%) were the most widely used statin drugs. Likelihood of treatment was associated with polypharmacy (≥5 drugs) and with higher Cumulative Illness Rating Scale (CIRS) score. At logistic regression analysis, the presence of coronary heart disease, peripheral vascular disease, and hypertension were significantly correlated with lipid-lowering drug use, whereas age showed an inverse correlation. Diabetes was not associated with drug treatment. Conclusions: In this in-hospital cohort, the use of lipid-lowering agents was mainly driven by patients’ clinical history, most notably the presence of clinically overt manifestations of atherosclerosis. Increasing age seems to be associated with lower prescription rates. This might be indicative of cautious behavior towards a potentially toxic treatment regimen.

UR - http://www.scopus.com/inward/record.url?scp=85015168921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015168921&partnerID=8YFLogxK

U2 - 10.1007/s40266-017-0448-8

DO - 10.1007/s40266-017-0448-8

M3 - Article

C2 - 28299634

AN - SCOPUS:85015168921

VL - 34

SP - 311

EP - 319

JO - Drugs and Aging

JF - Drugs and Aging

SN - 1170-229X

IS - 4

ER -