Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients: the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study

Marco Bertolotti, Carlotta Franchi, Marco B.L. Rocchi, Andrea Miceli, M. Vittoria Libbra, Alessandro Nobili, Giulia Lancellotti, Lucia Carulli, Chiara Mussi, Pier Mannuccio Mannucci, Mauro Tettamanti, Luca Pasina, Francesco Perticone, Francesco Salerno, Salvatore Corrao, Alessandra Marengoni, Giuseppe Licata, Francesco Violi, Gino Roberto Corazza, Maura MarcucciTarek Kamal Eldin, Maria Pia Donatella Di Blanca, Giovanna Lanzo, Sarah Astuto, Ilaria Ardoino, Laura Cortesi, Domenico Prisco, Elena Silvestri, Caterina Cenci, Giacomo Emmi, Gianni Biolo, Gianfranco Guarnieri, Michela Zanetti, Giovanni Fernandes, Massimiliano Chiuch, Massimo Vanoli, Giulia Grignani, Gianluca Casella, Edoardo Alessandro Pulixi, Mauro Bernardi, Silvia Li Bassi, Luca Santi, Giacomo Zaccherini, Elmo Mannarino, Graziana Lupattelli, Vanessa Bianconi, Francesco Paciullo, Ranuccio Nuti, Roberto Valenti, Martina Ruvio, Silvia Cappelli, Alberto Palazzuoli, Teresa Salvatore, Ferdinando Carlo Sasso, Domenico Girelli, Oliviero Olivieri, Thomas Matteazzi, Mario Barbagallo, Lidia Plances, Roberta Alcamo, Luigi Calvo, Maria Valenti, Franco Laghi Pasini, Pier Leopoldo Capecchi, Maurizio Bicchi, Giuseppe Palasciano, Maria Ester Modeo, Maria Peragine, Fabrizio Pappagallo, Stefania Pugliese, Carla Di Gennaro, Alfredo Postiglione, Maria Rosaria Barbella, Francesco De Stefano, Maria Domenica Cappellini, Giovanna Fabio, Sonia Seghezzi, Margherita Migone De Amicis, Marta Mancarella, Daniela Mari, Paolo Dionigi Rossi, Sarah Damanti, Barbara Brignolo Ottolini, Giulia Bonini, Emanuela Miceli, Marco Vincenzo Lenti, Donatella Padula, Giovanni Murialdo, Alessio Marra, Federico Cattaneo, Maria Beatrice Secchi, Davide Ghelfi, Luigi Anastasio, Lucia Sofia, Maria Carbone, Giovanni Davì, Maria Teresa Guagnano, Simona Sestili, Gerardo Mancuso, Daniela Calipari, Mosè Bartone, Maria Rachele Meroni, Paolo Cavallo Perin, Bartolomeo Lorenzati, Gabriella Gruden, Graziella Bruno, Cristina Amione, Paolo Fornengo, Rodolfo Tassara, Deborah Melis, Lara Rebella, Giuseppe Delitala, Vincenzo Pretti, Maristella Salvatora Masala, Chiara Pes, Luigi Bolondi, Leonardo Rasciti, Ilaria Serio, Filippo Rossi Fanelli, Antonio Amoroso, Alessio Molfino, Enrico Petrillo, Giuseppe Zuccalà, Francesco Franceschi, Guido De Marco, Cordischi Chiara, Sabbatini Marta, Gabriella D’Aurizio, Giuseppe Romanelli, Claudia Amolini, Deborah Chiesa, Antonio Picardi, Umberto Vespasiani Gentilucci, Paolo Gallo, Giorgio Annoni, Maurizio Corsi, Sara Zazzetta, Giuseppe Bellelli, Hajnalka Szabo, Franco Arturi, Elena Succurro, Mariangela Rubino, Giorgio Sesti, Paola Loria, Maria Angela Becchi, Gianfranco Martucci, Alessandra Fantuzzi, Mauro Maurantonio, Maria Grazia Serra, Maria Antonietta Bleve, Laura Gasbarrone, Maria Rosaria Sajeva, Antonio Brucato, Silvia Ghidoni, Paola Di Corato, Giancarlo Agnelli, Emanuela Marchesini, Fabrizio Fabris, Michela Carlon, Francesca Turatto, Aldo Baritusso, Annalisa Amabile, Elisabetta Omenetto, Paolo Scarinzi, Roberto Manfredini, Christian Molino, Marco Pala, Fabio Fabbian, Benedetta Boari, Alfredo De Giorgi, Giuseppe Paolisso, Maria Rosaria Rizzo, Maria Teresa Laieta, Giovanbattista Rini, Pasquale Mansueto, Ilenia Pepe, Claudio Borghi, Enrico Strocchi, Valeria De Sando, Ilaria Pareo, Carlo Sabbà, Francesco Saverio Vella, Patrizia Suppressa, Raffaella Valerio, Pasquale Agosti, Flavia Fontana, Francesca Loparco, Caterina Capobianco, Luigi Fenoglio, Christian Bracco, Alessia Valentina Giraudo, Elisa Testa, Cristina Serraino, Silvia Fargion, Paola Bonara, Giulia Periti, Marianna Porzio, Slivia Tiraboschi, Flora Peyvandi, Alberto Tedeschi, Raffaella Rossio, Barbara Ferrari, Valter Monzani, Valeria Savojardo, Christian Folli, Maria Magnini Francesco Salerno, Alessio Conca, Giulia Gobbo, Giada Pallini, Miriam Valenti, Carlo L. Balduini, Giampiera Bertolino, Stella Provini, Federica Quaglia, Franco Dallegri, Luciano Ottonello, Luca Liberale, Wu Sheng Chin, Laura Carassale, Silvia Caporotundo, Giancarlo Traisci, Lucrezia De Feudis, Silvia Di Carlo, Nicola Lucio Liberato, Alberto Buratti, Tiziana Tognin, Giovanni Battista Bianchi, Sabrina Giaquinto, Francesco Purrello, Antonino Di Pino, Salvatore Piro, Renzo Rozzini, Lina Falanga, Elena Spazzini, Giuseppe Montrucchio, Elisabetta Greco, Pietro Tizzani, Paolo Petitti, Antonio Perciccante, Alessia Coralli, Raffaella Salmi, Piergiorgio Gaudenzi, Susanna Gamberini, Andrea Semplicini, Lucia Gottardo, Gianluigi Vendemiale, Gaetano Serviddio, Roberta Forlano, Cesare Masala, Antonio Mammarella, Valeria Raparelli, Stefania Basili, Ludovica Perri, Raffaele Landolfi, Massimo Montalto, Antonio Mirijello, Carla Vallone, Martino Bellusci, Donatella Setti, Filippo Pedrazzoli, Luigina Guasti, Luana Castiglioni, Andrea Maresca, Alessandro Squizzato, Marta Molaro, Elisa Pellegrini, Francesca Veltri, Angela Sciacqua, Michele Quero, Chiara Bagnato, Lidia Colangelo, Tania Falbo, Roberto De Giorgio, Mauro Serra, Valentina Grasso, Eugenio Ruggeri, Benzoni Ilaria, Andrea Salvi, Roberto Leonardi, Chiara Grassini, Ilenia Mascherona, Giorgio Minelli, Francesca Maltese, Giampaolo Damiani, William Capeci, Massimo Mattioli, Giuseppe Pio Martino, Lorenzo Biondi, Monica Ormas, Pietro Pettinari, Roberto Romiti, Silvia Messina, Federica Cavallaro, Riccardi Ghio, Serena Favorini, Anna Dal Col, Salvatore Minisola, Luciano Colangelo, Antonella Afeltra, Pamela Alemanno, Benedetta Marigliano, Maria Elena Pipita, Pietro Castellino, Julien Blanco, Luca Zanoli, Marco Cattaneo, Paola Fracasso, Maria Valentina Amoruso, Valter Saracco, Marisa Fogliati, Carlo Bussolino, Vittorio Durante, Giovanna Eusebi, Daniela Tirotta, Francesca Mete, Miriam Gino, Antonio Cittadini, Carlo Vigorito, Michele Arcopinto, Andrea Salzano, Emanuele Bobbio, Alberto Maria Marra, Domenico Sirico, Guido Moreo, Francesco Scopelliti, Francesca Gasparini, Melissa Cocca, Alberto Ballestrero, Fabio Ferrando, Sergio Berra, Simonetta Dassi, Maria Cristina Nava, Bruno Graziella, Stefano Baldassarre, Salvatore Fragapani, Giorgio Galanti, Gabriele Mascherini, Cristian Petri, Laura Stefani, Margherita Girino, Valeria Piccinelli, Francesco Nasso, Vincenza Gioffrè, Maria Pasquale, Giuseppe Scattolin, Sergio Martinelli, Mauro Turrin, Leonardo Sechi, Cristina Catena, Gianluca Colussi, Ramirez Duque Nieves, Muela Molinero Alberto, Abad Requejo Pedro, Lopez Pelaez Vanessa, Tamargo Lara, Corbella Viros Xavier, Formiga Francesc, Diez Manglano Jesus, Bejarano Tello Esperanza, Del Corral Behamonte Esther, Sevil Puras Maria, Manuel Romero, Pinilla Llorente Blanca, Lopez Gonzalez Cobos Cristina, Villalba Garcia M. Victoria, Lopez Saez, Juan Bosco, Sanz Baena Susana, Arroyo Gallego Marta, Gonzalez Becerra Concepcion, Fernandez Moyano Antonio, Mercedes Gomez Hernandez, Manuel Poyato Borrego, Pacheco Cuadros Raquel, Perez Rojas Florencia, Garcia Olid Beatriz, Carrascosa Garcia Sara, Gonzalez Cruz Cervellera Alfonso, Peinado Martinez Marta, Sara Carrascosa Garcia, Ruiz Cantero Alberto, Albarracín Arraigosa Antonio, Godoy Guerrero Montserrat, Barón Ramos Miguel Ángel, Machin Jose Manuel, Novo Veleiro Ignacio, Alvela Suarez Lucía, Lopez Alfonso, Rubal Bran David, Iñiguez Vazquez Iria, Rios Prego Monica

Research output: Contribution to journalArticle

Abstract

Background: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. Aim: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. Methods: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical profiles, including multimorbidity markers and polypharmacy. Results: 2171 patients aged >65 years were enrolled (1057 males, 1114 females, mean age 78.6 years). The patients treated with lipid-lowering drugs amounted to 508 subjects (23.4%), with no gender difference. Atorvastatin (39.3%) and simvastatin (34.0%) were the most widely used statin drugs. Likelihood of treatment was associated with polypharmacy (≥5 drugs) and with higher Cumulative Illness Rating Scale (CIRS) score. At logistic regression analysis, the presence of coronary heart disease, peripheral vascular disease, and hypertension were significantly correlated with lipid-lowering drug use, whereas age showed an inverse correlation. Diabetes was not associated with drug treatment. Conclusions: In this in-hospital cohort, the use of lipid-lowering agents was mainly driven by patients’ clinical history, most notably the presence of clinically overt manifestations of atherosclerosis. Increasing age seems to be associated with lower prescription rates. This might be indicative of cautious behavior towards a potentially toxic treatment regimen.

Original languageEnglish
Pages (from-to)311-319
Number of pages9
JournalDrugs and Aging
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

    Fingerprint

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Pharmacology (medical)

Cite this