Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa

Rosella Tuveri, Jean Luc Perret, Eric Delaporte, Celestin Nguemby-Mbina, Laure Revault D'Allones, Daniel Henzel, Djamila Faivre, Bachisio Scarpa, Paolo Contu, Massimo Colombo, Valèrie Thiers, Christian Bréchot, Bernard Larouze

Research output: Contribution to journalArticle

Abstract

The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV antibodies. Among pregnant women, 29 of 229 (12.6%) were Hepatitis GB virus-C and Hepatitis G virus (GBV-C/ HGV) RNA positive (+) and 32 of 81 (39.5%) anti-E2 + versus 8 of 39 (20.5%) TTV DNA +. Among sickle cell anemia patients, 9.7% (3/31) were GBV-C/HGV RNA + versus 22.5% (7/31) TTV DNA +. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n = 27) versus controls (n = 66) did not show significant differences for GBV-C/ HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n = 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume63
Issue number3-4
Publication statusPublished - Sep 2000

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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    Tuveri, R., Perret, J. L., Delaporte, E., Nguemby-Mbina, C., D'Allones, L. R., Henzel, D., Faivre, D., Scarpa, B., Contu, P., Colombo, M., Thiers, V., Bréchot, C., & Larouze, B. (2000). Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa. American Journal of Tropical Medicine and Hygiene, 63(3-4), 192-198.