Abstract
Background. A recently identified DNA transfusion-transmitted virus has been associated with post-transfusion non-A to G hepatitis. Aim. To determine the prevalence of transfusion-transmitted virus in patients with human immunodeficiency virus infection. Its clinical role in the pathogenesis of liver disease was also evaluated in patients with transfusion-transmitted-virus hepatitis C virus coinfection compared with those with hepatitis C Virus infection alone. Patients and Methods. We evaluated 312 HIV-hepatitis C virus coinfected patients (225 males, 87 females). All underwent screening for transfusion-transmitted virus DNA using a nested polymerase chain reaction technique. In some transfusion transmitted virus-DNA positive patients, we performed a phylogenetic analysis. In 56 patients (20 transfusion-transmitted-virus-hepatitis C virus and 36 hepatitis C virus alone), liver biopsy was collected. Results. The prevalence of transfusion-transmitted virus was 113/312 (36%). The genotype distribution was similar to that reported in other studies. No difference in liver histology was found between the two groups. Conclusion. Transfusion-transmitted virus infection is common in human immunodeficiency virus patients. We found no histologic differences between liver biopsy specimens from patients coinfected with transfusion-transmitted virus plus hepatitis C virus compared with those infected with hepatitis C virus alone. Transfusion-transmitted virus is not clearly associated with a distinct liver injury.
| Original language | English |
|---|---|
| Pages (from-to) | 617-620 |
| Number of pages | 4 |
| Journal | Digestive and Liver Disease |
| Volume | 32 |
| Issue number | 7 |
| Publication status | Published - 2000 |
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Keywords
- Hepatitis
- Human immunodeficiency virus
- Transfusion-transmitted virus
ASJC Scopus subject areas
- Gastroenterology
Cite this
Prevalence and histologic features of transfusion transmitted virus and hepatitis C virus coinfection in a group of HIV patients. / Bruno, R.; Sacchi, P.; Debiaggi, M.; Patruno, S. F A; Zara, F.; Ciappina, V.; Brunetti, E.; Filice, C.; Zocchetti, C.; Maffezzini, E.; Pistorio, A.; Filice, G.
In: Digestive and Liver Disease, Vol. 32, No. 7, 2000, p. 617-620.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevalence and histologic features of transfusion transmitted virus and hepatitis C virus coinfection in a group of HIV patients
AU - Bruno, R.
AU - Sacchi, P.
AU - Debiaggi, M.
AU - Patruno, S. F A
AU - Zara, F.
AU - Ciappina, V.
AU - Brunetti, E.
AU - Filice, C.
AU - Zocchetti, C.
AU - Maffezzini, E.
AU - Pistorio, A.
AU - Filice, G.
PY - 2000
Y1 - 2000
N2 - Background. A recently identified DNA transfusion-transmitted virus has been associated with post-transfusion non-A to G hepatitis. Aim. To determine the prevalence of transfusion-transmitted virus in patients with human immunodeficiency virus infection. Its clinical role in the pathogenesis of liver disease was also evaluated in patients with transfusion-transmitted-virus hepatitis C virus coinfection compared with those with hepatitis C Virus infection alone. Patients and Methods. We evaluated 312 HIV-hepatitis C virus coinfected patients (225 males, 87 females). All underwent screening for transfusion-transmitted virus DNA using a nested polymerase chain reaction technique. In some transfusion transmitted virus-DNA positive patients, we performed a phylogenetic analysis. In 56 patients (20 transfusion-transmitted-virus-hepatitis C virus and 36 hepatitis C virus alone), liver biopsy was collected. Results. The prevalence of transfusion-transmitted virus was 113/312 (36%). The genotype distribution was similar to that reported in other studies. No difference in liver histology was found between the two groups. Conclusion. Transfusion-transmitted virus infection is common in human immunodeficiency virus patients. We found no histologic differences between liver biopsy specimens from patients coinfected with transfusion-transmitted virus plus hepatitis C virus compared with those infected with hepatitis C virus alone. Transfusion-transmitted virus is not clearly associated with a distinct liver injury.
AB - Background. A recently identified DNA transfusion-transmitted virus has been associated with post-transfusion non-A to G hepatitis. Aim. To determine the prevalence of transfusion-transmitted virus in patients with human immunodeficiency virus infection. Its clinical role in the pathogenesis of liver disease was also evaluated in patients with transfusion-transmitted-virus hepatitis C virus coinfection compared with those with hepatitis C Virus infection alone. Patients and Methods. We evaluated 312 HIV-hepatitis C virus coinfected patients (225 males, 87 females). All underwent screening for transfusion-transmitted virus DNA using a nested polymerase chain reaction technique. In some transfusion transmitted virus-DNA positive patients, we performed a phylogenetic analysis. In 56 patients (20 transfusion-transmitted-virus-hepatitis C virus and 36 hepatitis C virus alone), liver biopsy was collected. Results. The prevalence of transfusion-transmitted virus was 113/312 (36%). The genotype distribution was similar to that reported in other studies. No difference in liver histology was found between the two groups. Conclusion. Transfusion-transmitted virus infection is common in human immunodeficiency virus patients. We found no histologic differences between liver biopsy specimens from patients coinfected with transfusion-transmitted virus plus hepatitis C virus compared with those infected with hepatitis C virus alone. Transfusion-transmitted virus is not clearly associated with a distinct liver injury.
KW - Hepatitis
KW - Human immunodeficiency virus
KW - Transfusion-transmitted virus
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UR - http://www.scopus.com/inward/citedby.url?scp=0033646429&partnerID=8YFLogxK
M3 - Article
VL - 32
SP - 617
EP - 620
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 7
ER -