Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease

The heredity survey

Pompilio Faggiano, Angela Pirillo, Raffaele Griffo, Marco Ambrosetti, Roberto Pedretti, Giampaolo Scorcu, Marika Werren, Oreste Febo, Gabriella Malfatto, Giuseppe Favretto, Filippo Sarullo, Francesco Antonini-Canterin, Gianni Zobbi, Pierluigi Temporelli, Alberico L. Catapano, On behalf of, Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and Rehabilitation

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and aims Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200–500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented. Methods Data were collected in patients admitted to programs of rehabilitation and secondary prevention in Italy. Potential FH was estimated using Dutch Lipid Clinic Network (DLCN) criteria. Potential FH was defined as having a total score ≥ 6. Results Among the 1438 consecutive patients evaluated, the prevalence of potential FH was 3.7%. The prevalence was inversely related to age, with a putative prevalence of 1:10 in those with < 55 yrs of age (male) and < 60 yrs (female). Definite FH (DLCN score > 8) had the highest percentages of patients after an ACS (75% vs 52.5% in the whole study population). At discharge, most patients were on high intensity statin therapy, but despite this, potential FH group still had a higher percentage of patients with LDL-C levels not at target and having a distance from the target higher than 50%. Conclusions Among patients with established coronary heart disease, the prevalence of potential FH is higher than in the general population; the results suggest that a correct identification of potential FH, especially in younger patients, may help to better manage their high cardiovascular risk.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalInternational Journal of Cardiology
Volume252
DOIs
Publication statusPublished - Feb 1 2018

Fingerprint

Hyperlipoproteinemia Type II
Heredity
Coronary Artery Disease
LDL Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inborn Genetic Diseases
Surveys and Questionnaires
Peripheral Arterial Disease
Secondary Prevention
Italy
Population
Coronary Disease
Cardiovascular Diseases
Rehabilitation
Lipids
Therapeutics

Keywords

  • Coronary artery disease
  • Familial hypercholesterolemia
  • Lower extremities peripheral disease
  • Prevalence
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Faggiano, P., Pirillo, A., Griffo, R., Ambrosetti, M., Pedretti, R., Scorcu, G., ... Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and Rehabilitation (2018). Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease: The heredity survey. International Journal of Cardiology, 252, 193-198. https://doi.org/10.1016/j.ijcard.2017.10.105

Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease : The heredity survey. / Faggiano, Pompilio; Pirillo, Angela; Griffo, Raffaele; Ambrosetti, Marco; Pedretti, Roberto; Scorcu, Giampaolo; Werren, Marika; Febo, Oreste; Malfatto, Gabriella; Favretto, Giuseppe; Sarullo, Filippo; Antonini-Canterin, Francesco; Zobbi, Gianni; Temporelli, Pierluigi; Catapano, Alberico L.; On behalf of; Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and Rehabilitation.

In: International Journal of Cardiology, Vol. 252, 01.02.2018, p. 193-198.

Research output: Contribution to journalArticle

Faggiano, P, Pirillo, A, Griffo, R, Ambrosetti, M, Pedretti, R, Scorcu, G, Werren, M, Febo, O, Malfatto, G, Favretto, G, Sarullo, F, Antonini-Canterin, F, Zobbi, G, Temporelli, P, Catapano, AL, On behalf of & Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and Rehabilitation 2018, 'Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease: The heredity survey', International Journal of Cardiology, vol. 252, pp. 193-198. https://doi.org/10.1016/j.ijcard.2017.10.105
Faggiano, Pompilio ; Pirillo, Angela ; Griffo, Raffaele ; Ambrosetti, Marco ; Pedretti, Roberto ; Scorcu, Giampaolo ; Werren, Marika ; Febo, Oreste ; Malfatto, Gabriella ; Favretto, Giuseppe ; Sarullo, Filippo ; Antonini-Canterin, Francesco ; Zobbi, Gianni ; Temporelli, Pierluigi ; Catapano, Alberico L. ; On behalf of ; Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and Rehabilitation. / Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease : The heredity survey. In: International Journal of Cardiology. 2018 ; Vol. 252. pp. 193-198.
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abstract = "Background and aims Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200–500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented. Methods Data were collected in patients admitted to programs of rehabilitation and secondary prevention in Italy. Potential FH was estimated using Dutch Lipid Clinic Network (DLCN) criteria. Potential FH was defined as having a total score ≥ 6. Results Among the 1438 consecutive patients evaluated, the prevalence of potential FH was 3.7{\%}. The prevalence was inversely related to age, with a putative prevalence of 1:10 in those with < 55 yrs of age (male) and < 60 yrs (female). Definite FH (DLCN score > 8) had the highest percentages of patients after an ACS (75{\%} vs 52.5{\%} in the whole study population). At discharge, most patients were on high intensity statin therapy, but despite this, potential FH group still had a higher percentage of patients with LDL-C levels not at target and having a distance from the target higher than 50{\%}. Conclusions Among patients with established coronary heart disease, the prevalence of potential FH is higher than in the general population; the results suggest that a correct identification of potential FH, especially in younger patients, may help to better manage their high cardiovascular risk.",
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AU - Favretto, Giuseppe

AU - Sarullo, Filippo

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AU - Zobbi, Gianni

AU - Temporelli, Pierluigi

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