Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease

Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and Rehabilitation, Pompilio Faggiano, Angela Pirillo, Raffaele Griffo, Marco Ambrosetti, Roberto Pedretti, Giampaolo Scorcu, Marika Werren, Oreste Febo, Gabriella Malfatto, Giuseppe Favretto, Filippo Sarullo, Francesco Antonini-Canterin, Gianni Zobbi, Pierluigi Temporelli, Alberico L Catapano

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200-500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented.METHODS: Data were collected in patients admitted to programs of rehabilitation and secondary prevention in Italy. Potential FH was estimated using Dutch Lipid Clinic Network (DLCN) criteria. Potential FH was defined as having a total score≥6.RESULTS: Among the 1438 consecutive patients evaluated, the prevalence of potential FH was 3.7%. The prevalence was inversely related to age, with a putative prevalence of 1:10 in those with 8) had the highest percentages of patients after an ACS (75% vs 52.5% in the whole study population). At discharge, most patients were on high intensity statin therapy, but despite this, potential FH group still had a higher percentage of patients with LDL-C levels not at target and having a distance from the target higher than 50%.CONCLUSIONS: Among patients with established coronary heart disease, the prevalence of potential FH is higher than in the general population; the results suggest that a correct identification of potential FH, especially in younger patients, may help to better manage their high cardiovascular risk.
Original languageItalian
Pages (from-to)193-198
Number of pages6
JournalInternational Journal of Cardiology
Volume252
DOIs
Publication statusPublished - Feb 1 2018

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Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease. / Rehabilitation, Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and; Faggiano, Pompilio; Pirillo, Angela; Griffo, Raffaele; Ambrosetti, Marco; Pedretti, Roberto; Scorcu, Giampaolo; Werren, Marika; Febo, Oreste; Malfatto, Gabriella; Favretto, Giuseppe; Sarullo, Filippo; Antonini-Canterin, Francesco; Zobbi, Gianni; Temporelli, Pierluigi; Catapano, Alberico L.

In: International Journal of Cardiology, Vol. 252, 01.02.2018, p. 193-198.

Research output: Contribution to journalArticle

Rehabilitation, CSEFIAFCPA, Faggiano, P, Pirillo, A, Griffo, R, Ambrosetti, M, Pedretti, R, Scorcu, G, Werren, M, Febo, O, Malfatto, G, Favretto, G, Sarullo, F, Antonini-Canterin, F, Zobbi, G, Temporelli, P & Catapano, AL 2018, 'Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease', International Journal of Cardiology, vol. 252, pp. 193-198. https://doi.org/10.1016/j.ijcard.2017.10.105
Rehabilitation, Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and ; Faggiano, Pompilio ; Pirillo, Angela ; Griffo, Raffaele ; Ambrosetti, Marco ; Pedretti, Roberto ; Scorcu, Giampaolo ; Werren, Marika ; Febo, Oreste ; Malfatto, Gabriella ; Favretto, Giuseppe ; Sarullo, Filippo ; Antonini-Canterin, Francesco ; Zobbi, Gianni ; Temporelli, Pierluigi ; Catapano, Alberico L. / Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease. In: International Journal of Cardiology. 2018 ; Vol. 252. pp. 193-198.
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abstract = "BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200-500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented.METHODS: Data were collected in patients admitted to programs of rehabilitation and secondary prevention in Italy. Potential FH was estimated using Dutch Lipid Clinic Network (DLCN) criteria. Potential FH was defined as having a total score≥6.RESULTS: Among the 1438 consecutive patients evaluated, the prevalence of potential FH was 3.7{\%}. The prevalence was inversely related to age, with a putative prevalence of 1:10 in those with 8) had the highest percentages of patients after an ACS (75{\%} vs 52.5{\%} in the whole study population). At discharge, most patients were on high intensity statin therapy, but despite this, potential FH group still had a higher percentage of patients with LDL-C levels not at target and having a distance from the target higher than 50{\%}.CONCLUSIONS: Among patients with established coronary heart disease, the prevalence of potential FH is higher than in the general population; the results suggest that a correct identification of potential FH, especially in younger patients, may help to better manage their high cardiovascular risk.",
author = "Rehabilitation, {Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and} and Pompilio Faggiano and Angela Pirillo and Raffaele Griffo and Marco Ambrosetti and Roberto Pedretti and Giampaolo Scorcu and Marika Werren and Oreste Febo and Gabriella Malfatto and Giuseppe Favretto and Filippo Sarullo and Francesco Antonini-Canterin and Gianni Zobbi and Pierluigi Temporelli and Catapano, {Alberico L}",
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year = "2018",
month = "2",
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T1 - Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease

AU - Rehabilitation, Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and

AU - Faggiano, Pompilio

AU - Pirillo, Angela

AU - Griffo, Raffaele

AU - Ambrosetti, Marco

AU - Pedretti, Roberto

AU - Scorcu, Giampaolo

AU - Werren, Marika

AU - Febo, Oreste

AU - Malfatto, Gabriella

AU - Favretto, Giuseppe

AU - Sarullo, Filippo

AU - Antonini-Canterin, Francesco

AU - Zobbi, Gianni

AU - Temporelli, Pierluigi

AU - Catapano, Alberico L

N1 - Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200-500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented.METHODS: Data were collected in patients admitted to programs of rehabilitation and secondary prevention in Italy. Potential FH was estimated using Dutch Lipid Clinic Network (DLCN) criteria. Potential FH was defined as having a total score≥6.RESULTS: Among the 1438 consecutive patients evaluated, the prevalence of potential FH was 3.7%. The prevalence was inversely related to age, with a putative prevalence of 1:10 in those with 8) had the highest percentages of patients after an ACS (75% vs 52.5% in the whole study population). At discharge, most patients were on high intensity statin therapy, but despite this, potential FH group still had a higher percentage of patients with LDL-C levels not at target and having a distance from the target higher than 50%.CONCLUSIONS: Among patients with established coronary heart disease, the prevalence of potential FH is higher than in the general population; the results suggest that a correct identification of potential FH, especially in younger patients, may help to better manage their high cardiovascular risk.

AB - BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200-500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented.METHODS: Data were collected in patients admitted to programs of rehabilitation and secondary prevention in Italy. Potential FH was estimated using Dutch Lipid Clinic Network (DLCN) criteria. Potential FH was defined as having a total score≥6.RESULTS: Among the 1438 consecutive patients evaluated, the prevalence of potential FH was 3.7%. The prevalence was inversely related to age, with a putative prevalence of 1:10 in those with 8) had the highest percentages of patients after an ACS (75% vs 52.5% in the whole study population). At discharge, most patients were on high intensity statin therapy, but despite this, potential FH group still had a higher percentage of patients with LDL-C levels not at target and having a distance from the target higher than 50%.CONCLUSIONS: Among patients with established coronary heart disease, the prevalence of potential FH is higher than in the general population; the results suggest that a correct identification of potential FH, especially in younger patients, may help to better manage their high cardiovascular risk.

U2 - 10.1016/j.ijcard.2017.10.105

DO - 10.1016/j.ijcard.2017.10.105

M3 - Articolo

VL - 252

SP - 193

EP - 198

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -