Abstract
| Original language | Italian |
|---|---|
| Pages (from-to) | 193-198 |
| Number of pages | 6 |
| Journal | International Journal of Cardiology |
| Volume | 252 |
| DOIs | |
| Publication status | Published - Feb 1 2018 |
Cite this
Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease. / Rehabilitation, Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and; Faggiano, Pompilio; Pirillo, Angela; Griffo, Raffaele; Ambrosetti, Marco; Pedretti, Roberto; Scorcu, Giampaolo; Werren, Marika; Febo, Oreste; Malfatto, Gabriella; Favretto, Giuseppe; Sarullo, Filippo; Antonini-Canterin, Francesco; Zobbi, Gianni; Temporelli, Pierluigi; Catapano, Alberico L.
In: International Journal of Cardiology, Vol. 252, 01.02.2018, p. 193-198.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Prevalence and management of familial hypercholesterolemia in patients with coronary artery disease
AU - Rehabilitation, Centro Studi e Formazione - Italian Association for Cardiovascular Prevention and
AU - Faggiano, Pompilio
AU - Pirillo, Angela
AU - Griffo, Raffaele
AU - Ambrosetti, Marco
AU - Pedretti, Roberto
AU - Scorcu, Giampaolo
AU - Werren, Marika
AU - Febo, Oreste
AU - Malfatto, Gabriella
AU - Favretto, Giuseppe
AU - Sarullo, Filippo
AU - Antonini-Canterin, Francesco
AU - Zobbi, Gianni
AU - Temporelli, Pierluigi
AU - Catapano, Alberico L
N1 - Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200-500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented.METHODS: Data were collected in patients admitted to programs of rehabilitation and secondary prevention in Italy. Potential FH was estimated using Dutch Lipid Clinic Network (DLCN) criteria. Potential FH was defined as having a total score≥6.RESULTS: Among the 1438 consecutive patients evaluated, the prevalence of potential FH was 3.7%. The prevalence was inversely related to age, with a putative prevalence of 1:10 in those with 8) had the highest percentages of patients after an ACS (75% vs 52.5% in the whole study population). At discharge, most patients were on high intensity statin therapy, but despite this, potential FH group still had a higher percentage of patients with LDL-C levels not at target and having a distance from the target higher than 50%.CONCLUSIONS: Among patients with established coronary heart disease, the prevalence of potential FH is higher than in the general population; the results suggest that a correct identification of potential FH, especially in younger patients, may help to better manage their high cardiovascular risk.
AB - BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200-500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented.METHODS: Data were collected in patients admitted to programs of rehabilitation and secondary prevention in Italy. Potential FH was estimated using Dutch Lipid Clinic Network (DLCN) criteria. Potential FH was defined as having a total score≥6.RESULTS: Among the 1438 consecutive patients evaluated, the prevalence of potential FH was 3.7%. The prevalence was inversely related to age, with a putative prevalence of 1:10 in those with 8) had the highest percentages of patients after an ACS (75% vs 52.5% in the whole study population). At discharge, most patients were on high intensity statin therapy, but despite this, potential FH group still had a higher percentage of patients with LDL-C levels not at target and having a distance from the target higher than 50%.CONCLUSIONS: Among patients with established coronary heart disease, the prevalence of potential FH is higher than in the general population; the results suggest that a correct identification of potential FH, especially in younger patients, may help to better manage their high cardiovascular risk.
U2 - 10.1016/j.ijcard.2017.10.105
DO - 10.1016/j.ijcard.2017.10.105
M3 - Articolo
VL - 252
SP - 193
EP - 198
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -