Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias

Stefano Luminari; Maria Goldaniga; Fulvia Ceccherelli; Andrea Guffanti; Emilio Bombardieri; Raffaella Marcheselli; Lilla Cro; Mariangela Colombi; Massimo Federico; Luca Baldini

doi:10.1046/j.1365-2141.2003.04353.x

Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias

Stefano Luminari, Maria Goldaniga, Fulvia Ceccherelli, Andrea Guffanti, Emilio Bombardieri, Raffaella Marcheselli, Lilla Cro, Mariangela Colombi, Massimo Federico, Luca Baldini

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

High serum Mucin-1 (sMUC-1) levels have been shown in patients with adenocarcinoma and multiple myeloma (MM). We evaluated sMUC-1 levels in 76 patients with MM, 6 with plasma cells leukaemia (PCL) and 89 with monoclonal gammopathy of undetermined significance, to establish prevalence data and verify its possible prognostic role. Of the 171 patients, 27 [16%; 95% confidence interval (CI): 10-21%] had high sMUC-1 levels compared with healthy subjects (1.5%; 95% CI: 0-4%). Elevated sMUC-1 levels in MM and PCL patients correlated with anaemia and elevated serum lactate dehydrogenase levels; these patients showed a shorter survival than those with normal sMUC-1 levels (median overall survival: 25 vs. 49 months, P = 0.003).

Original language	English
Pages (from-to)	772-774
Number of pages	3
Journal	British Journal of Haematology
Volume	121
Issue number	5
DOIs	https://doi.org/10.1046/j.1365-2141.2003.04353.x
Publication status	Published - Jun 2003

Keywords

CA15.3
Multiple myeloma
Overall survival
Prognostic factors
sMUC-1

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2003.04353.x

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title = "Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias",

abstract = "High serum Mucin-1 (sMUC-1) levels have been shown in patients with adenocarcinoma and multiple myeloma (MM). We evaluated sMUC-1 levels in 76 patients with MM, 6 with plasma cells leukaemia (PCL) and 89 with monoclonal gammopathy of undetermined significance, to establish prevalence data and verify its possible prognostic role. Of the 171 patients, 27 [16%; 95% confidence interval (CI): 10-21%] had high sMUC-1 levels compared with healthy subjects (1.5%; 95% CI: 0-4%). Elevated sMUC-1 levels in MM and PCL patients correlated with anaemia and elevated serum lactate dehydrogenase levels; these patients showed a shorter survival than those with normal sMUC-1 levels (median overall survival: 25 vs. 49 months, P = 0.003).",

keywords = "CA15.3, Multiple myeloma, Overall survival, Prognostic factors, sMUC-1",

author = "Stefano Luminari and Maria Goldaniga and Fulvia Ceccherelli and Andrea Guffanti and Emilio Bombardieri and Raffaella Marcheselli and Lilla Cro and Mariangela Colombi and Massimo Federico and Luca Baldini",

year = "2003",

month = jun,

doi = "10.1046/j.1365-2141.2003.04353.x",

language = "English",

volume = "121",

pages = "772--774",

journal = "British Journal of Haematology",

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T1 - Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias

AU - Luminari, Stefano

AU - Goldaniga, Maria

AU - Ceccherelli, Fulvia

AU - Guffanti, Andrea

AU - Bombardieri, Emilio

AU - Marcheselli, Raffaella

AU - Cro, Lilla

AU - Colombi, Mariangela

AU - Federico, Massimo

AU - Baldini, Luca

PY - 2003/6

Y1 - 2003/6

N2 - High serum Mucin-1 (sMUC-1) levels have been shown in patients with adenocarcinoma and multiple myeloma (MM). We evaluated sMUC-1 levels in 76 patients with MM, 6 with plasma cells leukaemia (PCL) and 89 with monoclonal gammopathy of undetermined significance, to establish prevalence data and verify its possible prognostic role. Of the 171 patients, 27 [16%; 95% confidence interval (CI): 10-21%] had high sMUC-1 levels compared with healthy subjects (1.5%; 95% CI: 0-4%). Elevated sMUC-1 levels in MM and PCL patients correlated with anaemia and elevated serum lactate dehydrogenase levels; these patients showed a shorter survival than those with normal sMUC-1 levels (median overall survival: 25 vs. 49 months, P = 0.003).

AB - High serum Mucin-1 (sMUC-1) levels have been shown in patients with adenocarcinoma and multiple myeloma (MM). We evaluated sMUC-1 levels in 76 patients with MM, 6 with plasma cells leukaemia (PCL) and 89 with monoclonal gammopathy of undetermined significance, to establish prevalence data and verify its possible prognostic role. Of the 171 patients, 27 [16%; 95% confidence interval (CI): 10-21%] had high sMUC-1 levels compared with healthy subjects (1.5%; 95% CI: 0-4%). Elevated sMUC-1 levels in MM and PCL patients correlated with anaemia and elevated serum lactate dehydrogenase levels; these patients showed a shorter survival than those with normal sMUC-1 levels (median overall survival: 25 vs. 49 months, P = 0.003).

KW - CA15.3

KW - Multiple myeloma

KW - Overall survival

KW - Prognostic factors

KW - sMUC-1

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JO - British Journal of Haematology

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Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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