Prevalence and prognostic value of concealed structural abnormalities in patients with apparently idiopathic ventricular arrhythmias of left versus right ventricular origin: A magnetic resonance imaging study

Gaetano Nucifora, Daniele Muser, Pier Giorgio Masci, Andrea Barison, Luca Rebellato, Gianluca Piccoli, Elisabetta Daleffe, Mauro Toniolo, Davide Zanuttini, Domenico Facchin, Massimo Lombardi, Alessandro Proclemer

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background-Routine diagnostic work-up occasionally does not identify any abnormality among patients with monomorphic ventricular arrhythmias (VAs) of left ventricular (LV) origin. Aim of this study was to investigate the value of cardiac MRI (cMRI) for the diagnostic work-up and prognostication of these patients. Methods and Results-Forty-six consecutive patients (65% males; mean age, 44±15 years) with monomorphic VA s of LV origin and negative routine diagnostic work-up were included. Seventy-four consecutive patients (60% males; mean age, 40±17 years) with apparently idiopathic monomorphic VA s of right ventricular origin served as control group. Both groups underwent comprehensive cMRI study and were followed-up for a median of 14 months (25th-75th percentiles, 7-37 months). The outcome event was an arrhythmic composite end point of sudden cardiac death or nonfatal episode of ventricular fbrillation or sustained ventricular tachycardia requiring external cardioversion or appropriate implantable cardioverter defbrillator therapy. The 2 groups of patients did not differ in age (P=0.14) and sex (P=0.57). No signifcant difference was observed between patients with VAs of LV origin and VAs of right ventricular origin about biventricular volumes and systolic function. cMRI demonstrated myocardial structural abnormalities in 19 (41%) patients with VAs of LV origin versus 4 (5%) patients with VA s of right ventricular origin (P

Original languageEnglish
Pages (from-to)456-462
Number of pages7
JournalCirculation: Arrhythmia and Electrophysiology
Volume7
Issue number3
DOIs
Publication statusPublished - 2014

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Cardiac Arrhythmias
Magnetic Resonance Imaging
Electric Countershock
Sudden Cardiac Death
Ventricular Tachycardia
Control Groups

Keywords

  • Arrhythmias, cardiac
  • Arrhythmogenic right ventricular dysplasia
  • Fbrosis
  • Heart ventricles
  • Magnetic resonance imaging
  • Myocarditis
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Prevalence and prognostic value of concealed structural abnormalities in patients with apparently idiopathic ventricular arrhythmias of left versus right ventricular origin : A magnetic resonance imaging study. / Nucifora, Gaetano; Muser, Daniele; Masci, Pier Giorgio; Barison, Andrea; Rebellato, Luca; Piccoli, Gianluca; Daleffe, Elisabetta; Toniolo, Mauro; Zanuttini, Davide; Facchin, Domenico; Lombardi, Massimo; Proclemer, Alessandro.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 7, No. 3, 2014, p. 456-462.

Research output: Contribution to journalArticle

Nucifora, Gaetano ; Muser, Daniele ; Masci, Pier Giorgio ; Barison, Andrea ; Rebellato, Luca ; Piccoli, Gianluca ; Daleffe, Elisabetta ; Toniolo, Mauro ; Zanuttini, Davide ; Facchin, Domenico ; Lombardi, Massimo ; Proclemer, Alessandro. / Prevalence and prognostic value of concealed structural abnormalities in patients with apparently idiopathic ventricular arrhythmias of left versus right ventricular origin : A magnetic resonance imaging study. In: Circulation: Arrhythmia and Electrophysiology. 2014 ; Vol. 7, No. 3. pp. 456-462.
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abstract = "Background-Routine diagnostic work-up occasionally does not identify any abnormality among patients with monomorphic ventricular arrhythmias (VAs) of left ventricular (LV) origin. Aim of this study was to investigate the value of cardiac MRI (cMRI) for the diagnostic work-up and prognostication of these patients. Methods and Results-Forty-six consecutive patients (65{\%} males; mean age, 44±15 years) with monomorphic VA s of LV origin and negative routine diagnostic work-up were included. Seventy-four consecutive patients (60{\%} males; mean age, 40±17 years) with apparently idiopathic monomorphic VA s of right ventricular origin served as control group. Both groups underwent comprehensive cMRI study and were followed-up for a median of 14 months (25th-75th percentiles, 7-37 months). The outcome event was an arrhythmic composite end point of sudden cardiac death or nonfatal episode of ventricular fbrillation or sustained ventricular tachycardia requiring external cardioversion or appropriate implantable cardioverter defbrillator therapy. The 2 groups of patients did not differ in age (P=0.14) and sex (P=0.57). No signifcant difference was observed between patients with VAs of LV origin and VAs of right ventricular origin about biventricular volumes and systolic function. cMRI demonstrated myocardial structural abnormalities in 19 (41{\%}) patients with VAs of LV origin versus 4 (5{\%}) patients with VA s of right ventricular origin (P",
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T1 - Prevalence and prognostic value of concealed structural abnormalities in patients with apparently idiopathic ventricular arrhythmias of left versus right ventricular origin

T2 - A magnetic resonance imaging study

AU - Nucifora, Gaetano

AU - Muser, Daniele

AU - Masci, Pier Giorgio

AU - Barison, Andrea

AU - Rebellato, Luca

AU - Piccoli, Gianluca

AU - Daleffe, Elisabetta

AU - Toniolo, Mauro

AU - Zanuttini, Davide

AU - Facchin, Domenico

AU - Lombardi, Massimo

AU - Proclemer, Alessandro

PY - 2014

Y1 - 2014

N2 - Background-Routine diagnostic work-up occasionally does not identify any abnormality among patients with monomorphic ventricular arrhythmias (VAs) of left ventricular (LV) origin. Aim of this study was to investigate the value of cardiac MRI (cMRI) for the diagnostic work-up and prognostication of these patients. Methods and Results-Forty-six consecutive patients (65% males; mean age, 44±15 years) with monomorphic VA s of LV origin and negative routine diagnostic work-up were included. Seventy-four consecutive patients (60% males; mean age, 40±17 years) with apparently idiopathic monomorphic VA s of right ventricular origin served as control group. Both groups underwent comprehensive cMRI study and were followed-up for a median of 14 months (25th-75th percentiles, 7-37 months). The outcome event was an arrhythmic composite end point of sudden cardiac death or nonfatal episode of ventricular fbrillation or sustained ventricular tachycardia requiring external cardioversion or appropriate implantable cardioverter defbrillator therapy. The 2 groups of patients did not differ in age (P=0.14) and sex (P=0.57). No signifcant difference was observed between patients with VAs of LV origin and VAs of right ventricular origin about biventricular volumes and systolic function. cMRI demonstrated myocardial structural abnormalities in 19 (41%) patients with VAs of LV origin versus 4 (5%) patients with VA s of right ventricular origin (P

AB - Background-Routine diagnostic work-up occasionally does not identify any abnormality among patients with monomorphic ventricular arrhythmias (VAs) of left ventricular (LV) origin. Aim of this study was to investigate the value of cardiac MRI (cMRI) for the diagnostic work-up and prognostication of these patients. Methods and Results-Forty-six consecutive patients (65% males; mean age, 44±15 years) with monomorphic VA s of LV origin and negative routine diagnostic work-up were included. Seventy-four consecutive patients (60% males; mean age, 40±17 years) with apparently idiopathic monomorphic VA s of right ventricular origin served as control group. Both groups underwent comprehensive cMRI study and were followed-up for a median of 14 months (25th-75th percentiles, 7-37 months). The outcome event was an arrhythmic composite end point of sudden cardiac death or nonfatal episode of ventricular fbrillation or sustained ventricular tachycardia requiring external cardioversion or appropriate implantable cardioverter defbrillator therapy. The 2 groups of patients did not differ in age (P=0.14) and sex (P=0.57). No signifcant difference was observed between patients with VAs of LV origin and VAs of right ventricular origin about biventricular volumes and systolic function. cMRI demonstrated myocardial structural abnormalities in 19 (41%) patients with VAs of LV origin versus 4 (5%) patients with VA s of right ventricular origin (P

KW - Arrhythmias, cardiac

KW - Arrhythmogenic right ventricular dysplasia

KW - Fbrosis

KW - Heart ventricles

KW - Magnetic resonance imaging

KW - Myocarditis

KW - Prognosis

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