Abstract
Background-Routine diagnostic work-up occasionally does not identify any abnormality among patients with monomorphic ventricular arrhythmias (VAs) of left ventricular (LV) origin. Aim of this study was to investigate the value of cardiac MRI (cMRI) for the diagnostic work-up and prognostication of these patients. Methods and Results-Forty-six consecutive patients (65% males; mean age, 44±15 years) with monomorphic VA s of LV origin and negative routine diagnostic work-up were included. Seventy-four consecutive patients (60% males; mean age, 40±17 years) with apparently idiopathic monomorphic VA s of right ventricular origin served as control group. Both groups underwent comprehensive cMRI study and were followed-up for a median of 14 months (25th-75th percentiles, 7-37 months). The outcome event was an arrhythmic composite end point of sudden cardiac death or nonfatal episode of ventricular fbrillation or sustained ventricular tachycardia requiring external cardioversion or appropriate implantable cardioverter defbrillator therapy. The 2 groups of patients did not differ in age (P=0.14) and sex (P=0.57). No signifcant difference was observed between patients with VAs of LV origin and VAs of right ventricular origin about biventricular volumes and systolic function. cMRI demonstrated myocardial structural abnormalities in 19 (41%) patients with VAs of LV origin versus 4 (5%) patients with VA s of right ventricular origin (P
| Original language | English |
|---|---|
| Pages (from-to) | 456-462 |
| Number of pages | 7 |
| Journal | Circulation: Arrhythmia and Electrophysiology |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Arrhythmias, cardiac
- Arrhythmogenic right ventricular dysplasia
- Fbrosis
- Heart ventricles
- Magnetic resonance imaging
- Myocarditis
- Prognosis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)
Cite this
Prevalence and prognostic value of concealed structural abnormalities in patients with apparently idiopathic ventricular arrhythmias of left versus right ventricular origin : A magnetic resonance imaging study. / Nucifora, Gaetano; Muser, Daniele; Masci, Pier Giorgio; Barison, Andrea; Rebellato, Luca; Piccoli, Gianluca; Daleffe, Elisabetta; Toniolo, Mauro; Zanuttini, Davide; Facchin, Domenico; Lombardi, Massimo; Proclemer, Alessandro.
In: Circulation: Arrhythmia and Electrophysiology, Vol. 7, No. 3, 2014, p. 456-462.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Prevalence and prognostic value of concealed structural abnormalities in patients with apparently idiopathic ventricular arrhythmias of left versus right ventricular origin
T2 - A magnetic resonance imaging study
AU - Nucifora, Gaetano
AU - Muser, Daniele
AU - Masci, Pier Giorgio
AU - Barison, Andrea
AU - Rebellato, Luca
AU - Piccoli, Gianluca
AU - Daleffe, Elisabetta
AU - Toniolo, Mauro
AU - Zanuttini, Davide
AU - Facchin, Domenico
AU - Lombardi, Massimo
AU - Proclemer, Alessandro
PY - 2014
Y1 - 2014
N2 - Background-Routine diagnostic work-up occasionally does not identify any abnormality among patients with monomorphic ventricular arrhythmias (VAs) of left ventricular (LV) origin. Aim of this study was to investigate the value of cardiac MRI (cMRI) for the diagnostic work-up and prognostication of these patients. Methods and Results-Forty-six consecutive patients (65% males; mean age, 44±15 years) with monomorphic VA s of LV origin and negative routine diagnostic work-up were included. Seventy-four consecutive patients (60% males; mean age, 40±17 years) with apparently idiopathic monomorphic VA s of right ventricular origin served as control group. Both groups underwent comprehensive cMRI study and were followed-up for a median of 14 months (25th-75th percentiles, 7-37 months). The outcome event was an arrhythmic composite end point of sudden cardiac death or nonfatal episode of ventricular fbrillation or sustained ventricular tachycardia requiring external cardioversion or appropriate implantable cardioverter defbrillator therapy. The 2 groups of patients did not differ in age (P=0.14) and sex (P=0.57). No signifcant difference was observed between patients with VAs of LV origin and VAs of right ventricular origin about biventricular volumes and systolic function. cMRI demonstrated myocardial structural abnormalities in 19 (41%) patients with VAs of LV origin versus 4 (5%) patients with VA s of right ventricular origin (P
AB - Background-Routine diagnostic work-up occasionally does not identify any abnormality among patients with monomorphic ventricular arrhythmias (VAs) of left ventricular (LV) origin. Aim of this study was to investigate the value of cardiac MRI (cMRI) for the diagnostic work-up and prognostication of these patients. Methods and Results-Forty-six consecutive patients (65% males; mean age, 44±15 years) with monomorphic VA s of LV origin and negative routine diagnostic work-up were included. Seventy-four consecutive patients (60% males; mean age, 40±17 years) with apparently idiopathic monomorphic VA s of right ventricular origin served as control group. Both groups underwent comprehensive cMRI study and were followed-up for a median of 14 months (25th-75th percentiles, 7-37 months). The outcome event was an arrhythmic composite end point of sudden cardiac death or nonfatal episode of ventricular fbrillation or sustained ventricular tachycardia requiring external cardioversion or appropriate implantable cardioverter defbrillator therapy. The 2 groups of patients did not differ in age (P=0.14) and sex (P=0.57). No signifcant difference was observed between patients with VAs of LV origin and VAs of right ventricular origin about biventricular volumes and systolic function. cMRI demonstrated myocardial structural abnormalities in 19 (41%) patients with VAs of LV origin versus 4 (5%) patients with VA s of right ventricular origin (P
KW - Arrhythmias, cardiac
KW - Arrhythmogenic right ventricular dysplasia
KW - Fbrosis
KW - Heart ventricles
KW - Magnetic resonance imaging
KW - Myocarditis
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=84905856933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905856933&partnerID=8YFLogxK
U2 - 10.1161/CIRCEP.113.001172
DO - 10.1161/CIRCEP.113.001172
M3 - Article
C2 - 24771543
AN - SCOPUS:84905856933
VL - 7
SP - 456
EP - 462
JO - Circulation: Arrhythmia and Electrophysiology
JF - Circulation: Arrhythmia and Electrophysiology
SN - 1941-3149
IS - 3
ER -