Abstract
Background and purpose To evaluate the prevalence and the prognostic implications of conduction delays in a large cohort of cardiac AL patients. Methods Echo Doppler and 12-lead ECG were collected in 344 consecutive patients in whom diagnosis of AL amyloidosis was concluded between 2008 and 2010. Patients were subdivided according to the presence (n = 240) or absence (n = 104) of cardiac involvement. Results When compared with patients without myocardial involvement, cardiac AL was associated with prolonged PQ, QRS, QT and QTc intervals (P <0.05), and with higher prevalence of intraventricular blocks (27.5% vs. 16.5%, P <0.05), that was associated with higher wall thickness, worse diastolic and regional systolic function, higher NT-proBNP values (all P <0.05), and higher mortality (P = 0.0001; median follow-up: 402 days). Conclusion Intraventricular conduction delays have a negative prognostic impact in patients with cardiac AL amyloidosis. Their presence should not be overlooked in the diagnostic workup, prompting a more accurate cardiological support.
Original language | English |
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Pages (from-to) | 327-335 |
Number of pages | 9 |
Journal | Annals of Noninvasive Electrocardiology |
Volume | 18 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 2013 |
Keywords
- amyloid
- conduction disturbances
- echocardiography
- electrocardiography
- prognosis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)