Background and purpose To evaluate the prevalence and the prognostic implications of conduction delays in a large cohort of cardiac AL patients. Methods Echo Doppler and 12-lead ECG were collected in 344 consecutive patients in whom diagnosis of AL amyloidosis was concluded between 2008 and 2010. Patients were subdivided according to the presence (n = 240) or absence (n = 104) of cardiac involvement. Results When compared with patients without myocardial involvement, cardiac AL was associated with prolonged PQ, QRS, QT and QTc intervals (P <0.05), and with higher prevalence of intraventricular blocks (27.5% vs. 16.5%, P <0.05), that was associated with higher wall thickness, worse diastolic and regional systolic function, higher NT-proBNP values (all P <0.05), and higher mortality (P = 0.0001; median follow-up: 402 days). Conclusion Intraventricular conduction delays have a negative prognostic impact in patients with cardiac AL amyloidosis. Their presence should not be overlooked in the diagnostic workup, prompting a more accurate cardiological support.
- conduction disturbances
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)