Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients

Piero Amodio, Franco Del Piccolo, Elena Pettenò, Daniela Mapelli, Paolo Angeli, Rosamaria Iemmolo, Maurizio Muraca, Carmine Musto, Giorgio Gerunda, Cristiano Rizzo, Carlo Merkel, Angelo Gatta

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Abstract

Background/Aims: The electroencephalogram (EEG) is frequently altered in cirrhotic patients. We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations. Methods: A series of 296 consecutive cirrhotic patients who had undergone quantified-EEG was studied. The median follow-up was 442 days, 128 patients had bouts of OHE and 78 patients died from liver-related causes. Another group of 124 cirrhotic patients with a median follow-up of 223 days was examined to validate the prognostic model. Results: EEG alterations were detected in 38% of the patients. The prevalence of EEG alterations was associated with the severity of cirrhosis (class B: odds ratio (OR) = 2.3, 95% confidence interval (CI) = 1.2-4.7; class C: OR = 3.5, 95% CI = 1.6-7.7), but not with the aetiology (alcoholic vs. non-alcoholic: OR = 0.9; 95% CI = 0.5-1.5). The EEG predicted the occurrence of OHE (X2 = 26; P <0.001) and mortality (X2 = 34; P <0.001), also adjusting for Child-Pugh class by a multivariate analysis. In the patients with a Child-Pugh score of ≥ 8, the EEG discriminated between those patients with a higher 1-year risk of OHE (hazard ratio (HR) = 3.3, 95% CI = 1.8-6.1) and death (HR = 3.1, 95% CI = 1.7-5.6). Conclusions: In conclusion, quantified-EEG had a prognostic value for the occurrence of bouts of OHE and mortality in cirrhotic patients.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalJournal of Hepatology
Volume35
Issue number1
DOIs
Publication statusPublished - 2001

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Electroencephalography
Hepatic Encephalopathy
Confidence Intervals
Odds Ratio
Mortality
Fibrosis
Multivariate Analysis
Liver

Keywords

  • Cirrhosis
  • Electroencephalogram
  • Hepatic encephalopathy
  • Spectral electroencephalogram analysis
  • Survival

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Amodio, P., Del Piccolo, F., Pettenò, E., Mapelli, D., Angeli, P., Iemmolo, R., ... Gatta, A. (2001). Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients. Journal of Hepatology, 35(1), 37-45. https://doi.org/10.1016/S0168-8278(01)00129-5

Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients. / Amodio, Piero; Del Piccolo, Franco; Pettenò, Elena; Mapelli, Daniela; Angeli, Paolo; Iemmolo, Rosamaria; Muraca, Maurizio; Musto, Carmine; Gerunda, Giorgio; Rizzo, Cristiano; Merkel, Carlo; Gatta, Angelo.

In: Journal of Hepatology, Vol. 35, No. 1, 2001, p. 37-45.

Research output: Contribution to journalArticle

Amodio, P, Del Piccolo, F, Pettenò, E, Mapelli, D, Angeli, P, Iemmolo, R, Muraca, M, Musto, C, Gerunda, G, Rizzo, C, Merkel, C & Gatta, A 2001, 'Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients', Journal of Hepatology, vol. 35, no. 1, pp. 37-45. https://doi.org/10.1016/S0168-8278(01)00129-5
Amodio, Piero ; Del Piccolo, Franco ; Pettenò, Elena ; Mapelli, Daniela ; Angeli, Paolo ; Iemmolo, Rosamaria ; Muraca, Maurizio ; Musto, Carmine ; Gerunda, Giorgio ; Rizzo, Cristiano ; Merkel, Carlo ; Gatta, Angelo. / Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients. In: Journal of Hepatology. 2001 ; Vol. 35, No. 1. pp. 37-45.
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T1 - Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients

AU - Amodio, Piero

AU - Del Piccolo, Franco

AU - Pettenò, Elena

AU - Mapelli, Daniela

AU - Angeli, Paolo

AU - Iemmolo, Rosamaria

AU - Muraca, Maurizio

AU - Musto, Carmine

AU - Gerunda, Giorgio

AU - Rizzo, Cristiano

AU - Merkel, Carlo

AU - Gatta, Angelo

PY - 2001

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N2 - Background/Aims: The electroencephalogram (EEG) is frequently altered in cirrhotic patients. We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations. Methods: A series of 296 consecutive cirrhotic patients who had undergone quantified-EEG was studied. The median follow-up was 442 days, 128 patients had bouts of OHE and 78 patients died from liver-related causes. Another group of 124 cirrhotic patients with a median follow-up of 223 days was examined to validate the prognostic model. Results: EEG alterations were detected in 38% of the patients. The prevalence of EEG alterations was associated with the severity of cirrhosis (class B: odds ratio (OR) = 2.3, 95% confidence interval (CI) = 1.2-4.7; class C: OR = 3.5, 95% CI = 1.6-7.7), but not with the aetiology (alcoholic vs. non-alcoholic: OR = 0.9; 95% CI = 0.5-1.5). The EEG predicted the occurrence of OHE (X2 = 26; P <0.001) and mortality (X2 = 34; P <0.001), also adjusting for Child-Pugh class by a multivariate analysis. In the patients with a Child-Pugh score of ≥ 8, the EEG discriminated between those patients with a higher 1-year risk of OHE (hazard ratio (HR) = 3.3, 95% CI = 1.8-6.1) and death (HR = 3.1, 95% CI = 1.7-5.6). Conclusions: In conclusion, quantified-EEG had a prognostic value for the occurrence of bouts of OHE and mortality in cirrhotic patients.

AB - Background/Aims: The electroencephalogram (EEG) is frequently altered in cirrhotic patients. We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations. Methods: A series of 296 consecutive cirrhotic patients who had undergone quantified-EEG was studied. The median follow-up was 442 days, 128 patients had bouts of OHE and 78 patients died from liver-related causes. Another group of 124 cirrhotic patients with a median follow-up of 223 days was examined to validate the prognostic model. Results: EEG alterations were detected in 38% of the patients. The prevalence of EEG alterations was associated with the severity of cirrhosis (class B: odds ratio (OR) = 2.3, 95% confidence interval (CI) = 1.2-4.7; class C: OR = 3.5, 95% CI = 1.6-7.7), but not with the aetiology (alcoholic vs. non-alcoholic: OR = 0.9; 95% CI = 0.5-1.5). The EEG predicted the occurrence of OHE (X2 = 26; P <0.001) and mortality (X2 = 34; P <0.001), also adjusting for Child-Pugh class by a multivariate analysis. In the patients with a Child-Pugh score of ≥ 8, the EEG discriminated between those patients with a higher 1-year risk of OHE (hazard ratio (HR) = 3.3, 95% CI = 1.8-6.1) and death (HR = 3.1, 95% CI = 1.7-5.6). Conclusions: In conclusion, quantified-EEG had a prognostic value for the occurrence of bouts of OHE and mortality in cirrhotic patients.

KW - Cirrhosis

KW - Electroencephalogram

KW - Hepatic encephalopathy

KW - Spectral electroencephalogram analysis

KW - Survival

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