Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: Results from an urban observational cohort

Valerio Tozzi, Pietro Balestra, Patrizia Lorenzini, Rita Bellagamba, Simonetta Galgani, Angela Corpolongo, Chrysoula Vlassi, Dora Larussa, Mauro Zaccarelli, Pasquale Noto, Ubaldo Visco-Comandini, Marinella Giulianelli, Giuseppe Ippolito, Andrea Antinori, Pasquale Narciso

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Abstract

To assess prevalence and risk factors for human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI), the authors performed a 7-year survey in the period 1996 to 2002. A total of 432 patients were examined. HIV-related NCI was diagnosed in 238 patients (55.1%), meeting the HIV dementia (HIV-D) criteria in 45 (10.4%). The prevalence of both NCI and HIV-D did not change significantly during the study period. Compared with patients without NCI, patients with NCI were older (40.4 versus 38.2 years; P = .003), had a higher prevalence of positive HCV serology (61.1% versus 38.9%; P = .003), and a lower nadir CD4 cell count (156 versus 222 cells/μl; P <.001). Compared with patients seen during 1996 to 1999, patients with NCI seen during 2000 to 2002 were older (40.7 versus 38.8 years; P = .004), had a less advanced disease stage (previous acquired immunodeficiency syndrome [AIDS] 28.8% versus 65.7%; P <.001) and a higher nadir CD4 count (174 versus 132 cells /μl; P = .026). This study showed an unchanged prevalence of both HIV-related NCI and HIV-D in the period 1996 to 2002. The authors found evidences for new additional potential risk factors for HIV-related NCI (older age, lower nadir CD4 count, positive hepatitis C virus [HCV] serology), and for a change of risk factors for NCI in the late highly active antiretroviral therapy (HAART) era (older age, less advanced disease, higher nadir CD4 count).

Original languageEnglish
Pages (from-to)265-273
Number of pages9
JournalJournal of NeuroVirology
Volume11
Issue number3
DOIs
Publication statusPublished - Jul 2005

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HIV
CD4 Lymphocyte Count
Serology
Hepacivirus
Highly Active Antiretroviral Therapy
Dementia
Acquired Immunodeficiency Syndrome

Keywords

  • Highly active antiretroviral therapy
  • HIV dementia
  • HIV infection
  • Neurocognitive impairment
  • Prevalence

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002 : Results from an urban observational cohort. / Tozzi, Valerio; Balestra, Pietro; Lorenzini, Patrizia; Bellagamba, Rita; Galgani, Simonetta; Corpolongo, Angela; Vlassi, Chrysoula; Larussa, Dora; Zaccarelli, Mauro; Noto, Pasquale; Visco-Comandini, Ubaldo; Giulianelli, Marinella; Ippolito, Giuseppe; Antinori, Andrea; Narciso, Pasquale.

In: Journal of NeuroVirology, Vol. 11, No. 3, 07.2005, p. 265-273.

Research output: Contribution to journalArticle

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abstract = "To assess prevalence and risk factors for human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI), the authors performed a 7-year survey in the period 1996 to 2002. A total of 432 patients were examined. HIV-related NCI was diagnosed in 238 patients (55.1{\%}), meeting the HIV dementia (HIV-D) criteria in 45 (10.4{\%}). The prevalence of both NCI and HIV-D did not change significantly during the study period. Compared with patients without NCI, patients with NCI were older (40.4 versus 38.2 years; P = .003), had a higher prevalence of positive HCV serology (61.1{\%} versus 38.9{\%}; P = .003), and a lower nadir CD4 cell count (156 versus 222 cells/μl; P <.001). Compared with patients seen during 1996 to 1999, patients with NCI seen during 2000 to 2002 were older (40.7 versus 38.8 years; P = .004), had a less advanced disease stage (previous acquired immunodeficiency syndrome [AIDS] 28.8{\%} versus 65.7{\%}; P <.001) and a higher nadir CD4 count (174 versus 132 cells /μl; P = .026). This study showed an unchanged prevalence of both HIV-related NCI and HIV-D in the period 1996 to 2002. The authors found evidences for new additional potential risk factors for HIV-related NCI (older age, lower nadir CD4 count, positive hepatitis C virus [HCV] serology), and for a change of risk factors for NCI in the late highly active antiretroviral therapy (HAART) era (older age, less advanced disease, higher nadir CD4 count).",
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AU - Vlassi, Chrysoula

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