Abstract
We described the characteristics in a referred cohort of type II diabetic patients in the Developing Education on Microalbuminuria for Awareness of renal and cardiovascular risk in Diabetes study evaluating the global prevalence and determinants of microalbuminuria (MA). A cross-sectional study evaluating 32 208 type II diabetic patients without known albuminuria from 33 countries was performed. Overall, 8057 patients were excluded, either because of prior known proteinuria or non-diabetic nephropathy (3670), or because of invalid urine collections (4387). One single random urinary albumin/creatinine ratio was obtained in 24 151 patients (75%). The overall global prevalence of normo-, micro-, and macroalbuminuria was 51, 39, and 10%, respectively. The Asian and Hispanic patients had the highest prevalence of a raised urinary albumin/creatinine ratio (55%) and Caucasians the lowest (40.6), P2 in 22% of the 11 573 patients with available data. Systolic BP below 130 mmHg was found in 33 and 43% had an HbA1c below 7%. The frequency of patients receiving aspirin was 32%, statins 29%, and BP-lowering therapy 63%. A high prevalence globally of MA and reduced kidney function, both conditions associated with enhanced renal and cardiovascular risk, was detected in type II diabetic patients without prior known nephropathy. Early detection, monitoring of vascular complications, and more aggressive multifactorial treatment aiming at renal and vascular protection are urgently needed.
| Original language | English |
|---|---|
| Pages (from-to) | 2057-2063 |
| Number of pages | 7 |
| Journal | Kidney International |
| Volume | 69 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jun 2006 |
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Keywords
- Blood pressure
- Kidney function
- Microalbuminuria
- Type II diabetes
ASJC Scopus subject areas
- Nephrology
Cite this
Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients : A global perspective. / Parving, H. H.; Lewis, J. B.; Ravid, M.; Remuzzi, G.; Hunsicker, L. G.
In: Kidney International, Vol. 69, No. 11, 06.2006, p. 2057-2063.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients
T2 - A global perspective
AU - Parving, H. H.
AU - Lewis, J. B.
AU - Ravid, M.
AU - Remuzzi, G.
AU - Hunsicker, L. G.
PY - 2006/6
Y1 - 2006/6
N2 - We described the characteristics in a referred cohort of type II diabetic patients in the Developing Education on Microalbuminuria for Awareness of renal and cardiovascular risk in Diabetes study evaluating the global prevalence and determinants of microalbuminuria (MA). A cross-sectional study evaluating 32 208 type II diabetic patients without known albuminuria from 33 countries was performed. Overall, 8057 patients were excluded, either because of prior known proteinuria or non-diabetic nephropathy (3670), or because of invalid urine collections (4387). One single random urinary albumin/creatinine ratio was obtained in 24 151 patients (75%). The overall global prevalence of normo-, micro-, and macroalbuminuria was 51, 39, and 10%, respectively. The Asian and Hispanic patients had the highest prevalence of a raised urinary albumin/creatinine ratio (55%) and Caucasians the lowest (40.6), P2 in 22% of the 11 573 patients with available data. Systolic BP below 130 mmHg was found in 33 and 43% had an HbA1c below 7%. The frequency of patients receiving aspirin was 32%, statins 29%, and BP-lowering therapy 63%. A high prevalence globally of MA and reduced kidney function, both conditions associated with enhanced renal and cardiovascular risk, was detected in type II diabetic patients without prior known nephropathy. Early detection, monitoring of vascular complications, and more aggressive multifactorial treatment aiming at renal and vascular protection are urgently needed.
AB - We described the characteristics in a referred cohort of type II diabetic patients in the Developing Education on Microalbuminuria for Awareness of renal and cardiovascular risk in Diabetes study evaluating the global prevalence and determinants of microalbuminuria (MA). A cross-sectional study evaluating 32 208 type II diabetic patients without known albuminuria from 33 countries was performed. Overall, 8057 patients were excluded, either because of prior known proteinuria or non-diabetic nephropathy (3670), or because of invalid urine collections (4387). One single random urinary albumin/creatinine ratio was obtained in 24 151 patients (75%). The overall global prevalence of normo-, micro-, and macroalbuminuria was 51, 39, and 10%, respectively. The Asian and Hispanic patients had the highest prevalence of a raised urinary albumin/creatinine ratio (55%) and Caucasians the lowest (40.6), P2 in 22% of the 11 573 patients with available data. Systolic BP below 130 mmHg was found in 33 and 43% had an HbA1c below 7%. The frequency of patients receiving aspirin was 32%, statins 29%, and BP-lowering therapy 63%. A high prevalence globally of MA and reduced kidney function, both conditions associated with enhanced renal and cardiovascular risk, was detected in type II diabetic patients without prior known nephropathy. Early detection, monitoring of vascular complications, and more aggressive multifactorial treatment aiming at renal and vascular protection are urgently needed.
KW - Blood pressure
KW - Kidney function
KW - Microalbuminuria
KW - Type II diabetes
UR - http://www.scopus.com/inward/record.url?scp=33646771273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646771273&partnerID=8YFLogxK
U2 - 10.1038/sj.ki.5000377
DO - 10.1038/sj.ki.5000377
M3 - Article
C2 - 16612330
AN - SCOPUS:33646771273
VL - 69
SP - 2057
EP - 2063
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 11
ER -