Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics

Maria Concetta Fargnoli, Gianfranco Altomare, Elisa Benati, Francesco Borgia, Paolo Broganelli, Anna Carbone, Sergio Chimenti, Sergio Donato, Giampiero Girolomoni, Giuseppe Micali, Erica Moggio, Aurora Parodi, Stefano Piaserico, Giuseppe Pistone, Concetta Potenza, Mario Puviani, Margherita Raucci, Sabina Vaccari, Stefano Veglio, Andrea ZancaKetty Peris

Research output: Contribution to journalArticle

Abstract

Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials & methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. Conclusions: AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.

Original languageEnglish
Pages (from-to)599-608
Number of pages10
JournalEuropean Journal of Dermatology
Volume27
Issue number6
DOIs
Publication statusPublished - Nov 1 2017

Keywords

  • Actinic keratosis
  • Italy
  • Prevalence
  • Risk factors

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics'. Together they form a unique fingerprint.

  • Cite this

    Fargnoli, M. C., Altomare, G., Benati, E., Borgia, F., Broganelli, P., Carbone, A., Chimenti, S., Donato, S., Girolomoni, G., Micali, G., Moggio, E., Parodi, A., Piaserico, S., Pistone, G., Potenza, C., Puviani, M., Raucci, M., Vaccari, S., Veglio, S., ... Peris, K. (2017). Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics. European Journal of Dermatology, 27(6), 599-608. https://doi.org/10.1684/ejd.2017.3126