Prevalence and severity of myocardial perfusion imaging abnormalities in inmate subjects

Roberta Assante, Emilia Zampella, Wanda Acampa, Carmela Nappi, Valeria Gaudieri, Nicola Frega, Davide D'Arienzo, Marianna Tuccillo, Pierpaolo Di Lorenzo, Claudio Buccelli, Mario Petretta, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review


Aim We evaluated the prevalence and severity of myocardial perfusion abnormalities among inmates undergoing cardiac single-photon emission computed tomography. We also compared the results with those obtained in a cohort of non-inmates. Methods Between January 2009 and December 2013, 2420 consecutive subjects (258 inmates and 2162 non-inmates) with suspected or known coronary artery disease underwent stress myocardial perfusion single-photon emission computed tomography (MPS) to our institution. The decision to submit inmates to MPS was taken by the physicians of the penal institutions or ordered by the court based on the survey of part. To account for differences in clinical characteristics between inmates and non-inmates, we created a propensity scorematched cohort considering clinical variables and stress type. Results Before matching, inmates were younger and had higher prevalence of male gender, smoking, chest pain, and previous myocardial infarction or revascularization (all p 0.001). After matching, all characteristics were comparable in 258 inmates and 258 non-inmates. The total amount of abnormal myocardium was similar in inmates and non-inmates before and after matching. Infarct size and severity were larger in inmates before (p 0.001) and after (p 0.01) matching and left ventricular ejection fraction was lower in inmates compared to non-inmates (p 0.01). Conclusions Detention is associated with larger infarct size compared to a general population of subjects referred to stress MPS also after matching for clinical variables and stress type. The similar prevalence of normal MPS in the matched cohort suggests that this imaging technique might be appropriate in inmates.

Original languageEnglish
Article numbere0133360
JournalPLoS One
Issue number7
Publication statusPublished - Jul 22 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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