Prevalence, characteristics, and treatment of fatigue in oncological cancer patients in Italy

a cross-sectional study of the Italian Network for Supportive Care in Cancer (NICSO)

NICSO (Network Italiano per le Cure di Supporto in Oncologia)

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Fatigue is one of the most distressing symptoms of cancer patients. Its characteristics and impact on quality of life have not been fully explored and treatment of cancer-related fatigue in Italian oncological centers has not been codified.

METHODS: A cross-sectional study was carried out on all patients attending for any reason the 24 participating centers in two non-consecutive days. Patients with fatigue filled out the Brief Fatigue Inventory (BFI) questionnaire and reported any pharmacological or non-pharmacological treatment for fatigue.

RESULTS: From October 2014 to May 2015, 1394 cancer patients agreed to participate in the study. Fatigue was referred by 866 (62.1%) of patients; its duration was > 4 months in 441 patients (50.9%). In the investigators' opinion, the most important (probable or almost sure) determinants of fatigue were reduced physical activity (271 patients), anxiety (149), pain (131), insomnia (125), anemia (123), and depression (123). Fatigue of moderate/severe intensity was reported by 43%/29.2% of patients, while usual fatigue in the last 24 h by 45%/33.1%, and the worst fatigue in the last 24 h by 33%/54.8%, respectively. Concerning the impact on quality of life, fatigue interfered moderately/severely with general activity in 30.8%/38.6% of patients, with mood in 26.1%/32.8%, with the ability to work in 27.9%/35.6%, with normal work in 26.7%/38.9%, with relationships with others in 21%/23.4% and with the ability to amuse themselves in 22.2%/33.1%. Only 117/866 patients (13.5%) received a pharmacological treatment represented by a corticosteroid in 101 patients (86.3%) while 188 patients (21.7%) received a non-pharmacological treatment such as physical exercise (120 patients, 63.8%) and various alimentary supplements (52 patients, 27.6%).

CONCLUSIONS: Cancer-related fatigue is frequently reported by oncological patients; its intensity and impact on quality of life is relevant.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalSupportive Care in Cancer
DOIs
Publication statusE-pub ahead of print - Aug 6 2018

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Italy
Fatigue
Cross-Sectional Studies
Neoplasms
Therapeutics
Aptitude
Quality of Life
Pharmacology
Exercise
Second Primary Neoplasms
Sleep Initiation and Maintenance Disorders
Anemia
Adrenal Cortex Hormones
Anxiety
Research Personnel
Depression

Cite this

Prevalence, characteristics, and treatment of fatigue in oncological cancer patients in Italy : a cross-sectional study of the Italian Network for Supportive Care in Cancer (NICSO). / NICSO (Network Italiano per le Cure di Supporto in Oncologia).

In: Supportive Care in Cancer, 06.08.2018, p. 1-7.

Research output: Contribution to journalArticle

@article{bfb9efdff86441148cb9c4e7e29e0584,
title = "Prevalence, characteristics, and treatment of fatigue in oncological cancer patients in Italy: a cross-sectional study of the Italian Network for Supportive Care in Cancer (NICSO)",
abstract = "BACKGROUND: Fatigue is one of the most distressing symptoms of cancer patients. Its characteristics and impact on quality of life have not been fully explored and treatment of cancer-related fatigue in Italian oncological centers has not been codified.METHODS: A cross-sectional study was carried out on all patients attending for any reason the 24 participating centers in two non-consecutive days. Patients with fatigue filled out the Brief Fatigue Inventory (BFI) questionnaire and reported any pharmacological or non-pharmacological treatment for fatigue.RESULTS: From October 2014 to May 2015, 1394 cancer patients agreed to participate in the study. Fatigue was referred by 866 (62.1{\%}) of patients; its duration was > 4 months in 441 patients (50.9{\%}). In the investigators' opinion, the most important (probable or almost sure) determinants of fatigue were reduced physical activity (271 patients), anxiety (149), pain (131), insomnia (125), anemia (123), and depression (123). Fatigue of moderate/severe intensity was reported by 43{\%}/29.2{\%} of patients, while usual fatigue in the last 24 h by 45{\%}/33.1{\%}, and the worst fatigue in the last 24 h by 33{\%}/54.8{\%}, respectively. Concerning the impact on quality of life, fatigue interfered moderately/severely with general activity in 30.8{\%}/38.6{\%} of patients, with mood in 26.1{\%}/32.8{\%}, with the ability to work in 27.9{\%}/35.6{\%}, with normal work in 26.7{\%}/38.9{\%}, with relationships with others in 21{\%}/23.4{\%} and with the ability to amuse themselves in 22.2{\%}/33.1{\%}. Only 117/866 patients (13.5{\%}) received a pharmacological treatment represented by a corticosteroid in 101 patients (86.3{\%}) while 188 patients (21.7{\%}) received a non-pharmacological treatment such as physical exercise (120 patients, 63.8{\%}) and various alimentary supplements (52 patients, 27.6{\%}).CONCLUSIONS: Cancer-related fatigue is frequently reported by oncological patients; its intensity and impact on quality of life is relevant.",
author = "{NICSO (Network Italiano per le Cure di Supporto in Oncologia)} and Fausto Roila and Guglielmo Fumi and Benedetta Ruggeri and Andrea Antonuzzo and Carla Ripamonti and Sonia Fatigoni and Luigi Cavanna and Stefania Gori and Alessandra Fabi and Nicola Marzano and Claudio Graiff and {De Sanctis}, Vitaliana and Aurora Mirabile and Samantha Serpentini and Chiara Bocci and Pino, {Maria Simona} and Giuseppina Cilenti and Claudio Verusio and Enzo Ballatori",
year = "2018",
month = "8",
day = "6",
doi = "10.1007/s00520-018-4393-9",
language = "English",
pages = "1--7",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer Verlag",

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TY - JOUR

T1 - Prevalence, characteristics, and treatment of fatigue in oncological cancer patients in Italy

T2 - a cross-sectional study of the Italian Network for Supportive Care in Cancer (NICSO)

AU - NICSO (Network Italiano per le Cure di Supporto in Oncologia)

AU - Roila, Fausto

AU - Fumi, Guglielmo

AU - Ruggeri, Benedetta

AU - Antonuzzo, Andrea

AU - Ripamonti, Carla

AU - Fatigoni, Sonia

AU - Cavanna, Luigi

AU - Gori, Stefania

AU - Fabi, Alessandra

AU - Marzano, Nicola

AU - Graiff, Claudio

AU - De Sanctis, Vitaliana

AU - Mirabile, Aurora

AU - Serpentini, Samantha

AU - Bocci, Chiara

AU - Pino, Maria Simona

AU - Cilenti, Giuseppina

AU - Verusio, Claudio

AU - Ballatori, Enzo

PY - 2018/8/6

Y1 - 2018/8/6

N2 - BACKGROUND: Fatigue is one of the most distressing symptoms of cancer patients. Its characteristics and impact on quality of life have not been fully explored and treatment of cancer-related fatigue in Italian oncological centers has not been codified.METHODS: A cross-sectional study was carried out on all patients attending for any reason the 24 participating centers in two non-consecutive days. Patients with fatigue filled out the Brief Fatigue Inventory (BFI) questionnaire and reported any pharmacological or non-pharmacological treatment for fatigue.RESULTS: From October 2014 to May 2015, 1394 cancer patients agreed to participate in the study. Fatigue was referred by 866 (62.1%) of patients; its duration was > 4 months in 441 patients (50.9%). In the investigators' opinion, the most important (probable or almost sure) determinants of fatigue were reduced physical activity (271 patients), anxiety (149), pain (131), insomnia (125), anemia (123), and depression (123). Fatigue of moderate/severe intensity was reported by 43%/29.2% of patients, while usual fatigue in the last 24 h by 45%/33.1%, and the worst fatigue in the last 24 h by 33%/54.8%, respectively. Concerning the impact on quality of life, fatigue interfered moderately/severely with general activity in 30.8%/38.6% of patients, with mood in 26.1%/32.8%, with the ability to work in 27.9%/35.6%, with normal work in 26.7%/38.9%, with relationships with others in 21%/23.4% and with the ability to amuse themselves in 22.2%/33.1%. Only 117/866 patients (13.5%) received a pharmacological treatment represented by a corticosteroid in 101 patients (86.3%) while 188 patients (21.7%) received a non-pharmacological treatment such as physical exercise (120 patients, 63.8%) and various alimentary supplements (52 patients, 27.6%).CONCLUSIONS: Cancer-related fatigue is frequently reported by oncological patients; its intensity and impact on quality of life is relevant.

AB - BACKGROUND: Fatigue is one of the most distressing symptoms of cancer patients. Its characteristics and impact on quality of life have not been fully explored and treatment of cancer-related fatigue in Italian oncological centers has not been codified.METHODS: A cross-sectional study was carried out on all patients attending for any reason the 24 participating centers in two non-consecutive days. Patients with fatigue filled out the Brief Fatigue Inventory (BFI) questionnaire and reported any pharmacological or non-pharmacological treatment for fatigue.RESULTS: From October 2014 to May 2015, 1394 cancer patients agreed to participate in the study. Fatigue was referred by 866 (62.1%) of patients; its duration was > 4 months in 441 patients (50.9%). In the investigators' opinion, the most important (probable or almost sure) determinants of fatigue were reduced physical activity (271 patients), anxiety (149), pain (131), insomnia (125), anemia (123), and depression (123). Fatigue of moderate/severe intensity was reported by 43%/29.2% of patients, while usual fatigue in the last 24 h by 45%/33.1%, and the worst fatigue in the last 24 h by 33%/54.8%, respectively. Concerning the impact on quality of life, fatigue interfered moderately/severely with general activity in 30.8%/38.6% of patients, with mood in 26.1%/32.8%, with the ability to work in 27.9%/35.6%, with normal work in 26.7%/38.9%, with relationships with others in 21%/23.4% and with the ability to amuse themselves in 22.2%/33.1%. Only 117/866 patients (13.5%) received a pharmacological treatment represented by a corticosteroid in 101 patients (86.3%) while 188 patients (21.7%) received a non-pharmacological treatment such as physical exercise (120 patients, 63.8%) and various alimentary supplements (52 patients, 27.6%).CONCLUSIONS: Cancer-related fatigue is frequently reported by oncological patients; its intensity and impact on quality of life is relevant.

U2 - 10.1007/s00520-018-4393-9

DO - 10.1007/s00520-018-4393-9

M3 - Article

SP - 1

EP - 7

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

ER -