TY - JOUR
T1 - Prevalence, Correlates and Outcomes of Smoking in Pregnant Women with HIV: A National Observational Study in Italy
AU - Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy
AU - Floridia, M.
AU - Ravizza, M.
AU - Masuelli, G.
AU - Tassis, B.
AU - Savasi, V.M.
AU - Liuzzi, G.
AU - Sansone, M.
AU - Simonazzi, G.
AU - Franceschetti, L.
AU - Meloni, A.
AU - Vimercati, A.
AU - Guaraldi, G.
AU - Pinnetti, C.
AU - Dalzero, S.
AU - Tamburrini, E.
N1 - Export Date: 10 December 2020
CODEN: SUMIF
PY - 2020
Y1 - 2020
N2 - Background: Few studies have evaluated in pregnant women with HIV the prevalence of smoking and its associations with maternal and neonatal outcomes. Objectives: to assess the prevalence of smoking among women with HIV in early pregnancy and the association between smoking and pregnancy outcomes in this particular population. Methods: We used data from a multicenter observational study to define the prevalence of smoking in women with HIV in early pregnancy, and the role of smoking status and intensity as risk factors for adverse maternal and neonatal outcomes. Main outcome measures were fetal growth restriction [FGR], preterm delivery [PD] and low birthweight [LB], evaluated in univariate and multivariate analyses. Results: The overall (2001–2018) prevalence of reported smoking (at least one cigarette/day) was 25.6% (792/3097), with a significant decrease in recent years (19.0% in 2013–2018). Women who smoked were less commonly African, had lower body mass index, older age, a longer history of HIV infection and higher CD4 counts. In univariate analyses, smokers were significantly more likely to have PD, LB, FGR and detectable HIV viral load at third trimester. Multivariable analyses confirmed for smokers a significantly higher risk of LB (adjusted odds ratio [AOR]: 1.69, 95%CI 1.22–2.34) and FGR (AOR 1.88, 95%CI 1.27–2.80), while the associations with detectable HIV and PD were not maintained. Conclusions: The common prevalence of smoking among pregnant women with HIV and its association with adverse outcomes indicates that smoking cessation programs in this population may have a significant impact on neonatal and maternal health.
AB - Background: Few studies have evaluated in pregnant women with HIV the prevalence of smoking and its associations with maternal and neonatal outcomes. Objectives: to assess the prevalence of smoking among women with HIV in early pregnancy and the association between smoking and pregnancy outcomes in this particular population. Methods: We used data from a multicenter observational study to define the prevalence of smoking in women with HIV in early pregnancy, and the role of smoking status and intensity as risk factors for adverse maternal and neonatal outcomes. Main outcome measures were fetal growth restriction [FGR], preterm delivery [PD] and low birthweight [LB], evaluated in univariate and multivariate analyses. Results: The overall (2001–2018) prevalence of reported smoking (at least one cigarette/day) was 25.6% (792/3097), with a significant decrease in recent years (19.0% in 2013–2018). Women who smoked were less commonly African, had lower body mass index, older age, a longer history of HIV infection and higher CD4 counts. In univariate analyses, smokers were significantly more likely to have PD, LB, FGR and detectable HIV viral load at third trimester. Multivariable analyses confirmed for smokers a significantly higher risk of LB (adjusted odds ratio [AOR]: 1.69, 95%CI 1.22–2.34) and FGR (AOR 1.88, 95%CI 1.27–2.80), while the associations with detectable HIV and PD were not maintained. Conclusions: The common prevalence of smoking among pregnant women with HIV and its association with adverse outcomes indicates that smoking cessation programs in this population may have a significant impact on neonatal and maternal health.
KW - HIV
KW - intrauterine growth retardation
KW - low birthweight
KW - pregnancy
KW - preterm delivery
KW - smoking
U2 - 10.1080/10826084.2020.1729204
DO - 10.1080/10826084.2020.1729204
M3 - Article
VL - 55
SP - 1165
EP - 1172
JO - Substance Use and Misuse
JF - Substance Use and Misuse
SN - 1082-6084
IS - 7
ER -