TY - JOUR
T1 - Prevalence, diagnosis and treatment of lower genital neoplasia in women with human immunodeficiency virus infection
AU - Spinillo, A.
AU - Tenti, P.
AU - Zappatore, R.
AU - Barbarini, G.
AU - Maccabruni, A.
AU - Carratta, L.
AU - Guaschino, S.
PY - 1992/2/28
Y1 - 1992/2/28
N2 - The prevalence of lower genital neoplasia and Human Papilloma-virus-related genital lesions were evaluated in a cohort of 75 women with Human Immunodeficiency Virus type 1 (HIV-1) infection at different stages of HIV disease. The overall rate of cervical intraepithelial neoplasia (CIN) in the group studied was 29.3% ( 22 75). Eight out of 10 high-grade CIN lesions contained 'high-risk' HPV-DNA 16 18 and/or 31/35/51 as demonstrated by 'in situ' hybridization with biotinylated probes. Vulvar and/or perianal condylomata were histologically diagnosed in 14 patients (18.7%); nine of these biopsies contained detectable HPV-DNA which was always related to HPV 6 11. The rate of high-grade CIN in symptomatic HIV-infected patients was 28% ( 7 25) as compared to 6% ( 3 50) of the other cases (P = 0.022). CD4 lymphocyte counts, white blood cell counts, CD4+ CD8+ cell ratio and percentage of CD4+ lymphocytes were lower in patients with high-grade CIN in comparison to the patients with negative colposcopical and/or cytological examination. After adequate standard treatment (cryotherapy, electrocauterization, cold-knife conization) only one case of CIN 2 recurred during the 2 years of follow-up period. The prevalence of lower genital neoplasia and HPV-related lesions among HIV-infected women is high and seems to correlate with the severity of HIV disease.
AB - The prevalence of lower genital neoplasia and Human Papilloma-virus-related genital lesions were evaluated in a cohort of 75 women with Human Immunodeficiency Virus type 1 (HIV-1) infection at different stages of HIV disease. The overall rate of cervical intraepithelial neoplasia (CIN) in the group studied was 29.3% ( 22 75). Eight out of 10 high-grade CIN lesions contained 'high-risk' HPV-DNA 16 18 and/or 31/35/51 as demonstrated by 'in situ' hybridization with biotinylated probes. Vulvar and/or perianal condylomata were histologically diagnosed in 14 patients (18.7%); nine of these biopsies contained detectable HPV-DNA which was always related to HPV 6 11. The rate of high-grade CIN in symptomatic HIV-infected patients was 28% ( 7 25) as compared to 6% ( 3 50) of the other cases (P = 0.022). CD4 lymphocyte counts, white blood cell counts, CD4+ CD8+ cell ratio and percentage of CD4+ lymphocytes were lower in patients with high-grade CIN in comparison to the patients with negative colposcopical and/or cytological examination. After adequate standard treatment (cryotherapy, electrocauterization, cold-knife conization) only one case of CIN 2 recurred during the 2 years of follow-up period. The prevalence of lower genital neoplasia and HPV-related lesions among HIV-infected women is high and seems to correlate with the severity of HIV disease.
KW - Human immunodeficiency virus infection
KW - Human papillomavirus infection
KW - Lower genital neoplasia
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U2 - 10.1016/0028-2243(92)90179-3
DO - 10.1016/0028-2243(92)90179-3
M3 - Article
C2 - 1314201
AN - SCOPUS:0026601553
VL - 43
SP - 235
EP - 241
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
SN - 0028-2243
IS - 3
ER -