Prevalence of acetowhite areas in male partners of women affected by HPV and squamous intra-epithelial lesions (SIL) and their prognostic significance. A multicenter study

Antonio Frega, Deborah French, Sebastiano Pace, Luca Maranghi, Antonella Palazzo, Roberto Iacovelli, Alberto Biamonti, Massimo Moscarini, Aldo Vecchione

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Estimates for the prevalence of cervical HPV infection vary and are only available for a few populations with regard to male partners. Attention has been drawn to the male role in cancer progression from cervical intra-epithelial neoplasia, but most of the male lesions are subclinical and only visible after acetowhite staining. The prognostic significance of acetowhite areas, of male partners of women affected by HPV and preneoplastic lesions, was evaluated. Materials and Methods: A cohort of 3210 male partners of women affected by HPV infection and/or preneoplastic lesion of the lower genital tract was observed from 1987 to 2001. Acetowhite changes were assessed 5 min after the application of 5% solution of acetic acid and biopsies were tested for HPV-DNA by PCR. Patients with HPV lesions underwent CO2 laser surgery and follow-up. Results: Of the 3210 male panners, 39.12% exhibited clinical HPV lesions and 3.64% subclinical lesions identified as acetowhite areas. In the group of 117 male partners with acetowhite areas, the HPV-DNA test was positive (HPV 6-11) in 36.75% and negative in 63.24% (p2 laser surgery (p

Original languageEnglish
Pages (from-to)3171-3174
Number of pages4
JournalAnticancer Research
Volume26
Issue number4 B
Publication statusPublished - Jul 2006

Keywords

  • Acetowhite areas
  • HPV
  • Male partners
  • SIL

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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