Prevalence of Achromobacter xylosoxidans in pulmonary mucosa-associated lymphoid tissue lymphoma in different regions of Europe

Patrick Adam, Piotr Czapiewski, Seba Colak, Perikles Kosmidis, Thomas Tousseyn, Xavier Sagaert, Ludmila Boudova, Krzysztof Okoń, Alicia Morresi-Hauf, Claudio Agostinelli, Stefano Pileri, Giancarlo Pruneri, Giovanni Martinelli, Ming Qing Du, Falko Fend

Research output: Contribution to journalArticlepeer-review

Abstract

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises 7-8% of B-cell lymphomas and commonly originates from a background of long-standing chronic inflammation. An association with distinct bacteria species has been confirmed for several anatomical sites of MALT lymphoma. For pulmonary MALT lymphoma, however, a clear link with an infectious agent or autoimmune disorder has not yet been reported. Using a 16S rRNA gene-based approach, we have recently identified Achromobacter (Alcaligenes) xylosoxidans in eight of nine cases of pulmonary MALT lymphoma. A. xylosoxidans is a gram-negative betaproteobacterium with low virulence, but high resistance to antibiotic treatment. To further examine a potential association with A. xylosoxidans, 124 cases of pulmonary MALT lymphoma and 82 control tissues from six European countries were analysed using a specific nested PCR. Although prevalence rates for A. xylosoxidans varied significantly from country to country, they were consistently higher for MALT lymphoma as compared to controls. Overall, 57/124 (46%) pulmonary MALT lymphomas and 15/82 (18%) control tissues were positive for A. xylosoxidans (P = 0·004). Whether the significant association of A. xylosoxidans with pulmonary MALT lymphoma demonstrated in our study points to a potential causal role in the pathogenesis of this lymphoma will require further studies.

Original languageEnglish
Pages (from-to)804-810
Number of pages7
JournalBritish Journal of Haematology
Volume164
Issue number6
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Achromobacter xylosoxidans
  • Geographical variability
  • Pulmonary MALT lymphoma

ASJC Scopus subject areas

  • Hematology

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