TY - JOUR
T1 - Prevalence of aging-associated cognitive decline in an Italian elderly population
T2 - Results from cross-sectional phase of Italian Project on Epidemiology of Alzheimer's disease (IPREA)
AU - Scafato, Emanuele
AU - Gandin, Claudia
AU - Galluzzo, Lucia
AU - Ghirini, Silvia
AU - Cacciatore, Francesco
AU - Capurso, Antonio
AU - Solfrizzi, Vincenzo
AU - Panza, Francesco
AU - Cocchi, Alberto
AU - Consoli, Domenico
AU - Enzi, Giuliano
AU - Frisoni, Giovanni B.
AU - Gandolfo, Carlo
AU - Giampaoli, Simona
AU - Inzitari, Domenico
AU - Maggi, Stefania
AU - Crepaldi, Gaetano
AU - Mariotti, Sergio
AU - Mecocci, Patrizia
AU - Motta, Massimo
AU - Negrini, Roberto
AU - Postacchini, Demetrio
AU - Rengo, Franco
AU - Farchi, Gino
AU - Martire, S.
AU - Gallina, P.
AU - Baldereschi, M.
AU - Di Carlo, A.
AU - Conti, M.
AU - Galluzzi, S.
AU - Cruciani, G.
AU - Giuli, C.
AU - Solfrizzi, V.
AU - Panza, F.
AU - Abete, P.
AU - Forti, P.
AU - Tabanelli, P.
AU - Zuccalà, G.
AU - Calabrese, C.
AU - Sica, G.
AU - Estraneo, A.
AU - Naso, F.
AU - Torcasio, G.
AU - Rinaldi, P.
AU - Serafini, V.
AU - Senin, U.
PY - 2010/10
Y1 - 2010/10
N2 - Background and aims: The prevalence of the preclinical phase of dementia varies greatly, according to the diagnostic criteria and assessment procedures applied. The purpose of this study was to estimate the prevalence of cognitive impairment according to the Aging-Associated Cognitive Decline (AACD) diagnostic criteria in an Italian elderly population. Methods: In a multicenter community-based prospective study, 4785 Italian subjects aged 65-84 years, randomly selected from the registries of 12 Italian municipalities, were assessed by personal and informant interviews, physical and neurological examinations and an extensive neuropsychological battery. Results: Of these older subjects, 274 (9.2%) fulfilled all the AACD criteria, whereas 561 (18.8%) fulfilled only 3 of them (AACD-3). When the two groups diagnosed according to AACD criteria (AACD and AACD-3) were merged, the prevalence was 28.0% (28.3% for men, 27.6% for women). Two other groups of subjects were also identified: a) Subjects with Qbjective evidence of Cognitive Decline without cognitive complaints (OCD), 508 (17.0%), i.e., subjects with documented neuropsychological deficits, although neither subjects nor informants reported cognitive complaints; and b) Subjects with Cognitive Complaints without objective demonstrable cognitive deficits (CC), 44 (1.5%), i.e., subjects and/or informants reported cognitive complaints without evidence of neuropsychological deficits. Thus, taking into account the additional OCD group, a total of 1343 persons with cognitive impairment without dementia (45.0%) was identified. Conclusions: On the basis of our results, we estimate that 45% of our population-based Italian sample aged 65-84 years had some kind of cognitive deficits without dementia.
AB - Background and aims: The prevalence of the preclinical phase of dementia varies greatly, according to the diagnostic criteria and assessment procedures applied. The purpose of this study was to estimate the prevalence of cognitive impairment according to the Aging-Associated Cognitive Decline (AACD) diagnostic criteria in an Italian elderly population. Methods: In a multicenter community-based prospective study, 4785 Italian subjects aged 65-84 years, randomly selected from the registries of 12 Italian municipalities, were assessed by personal and informant interviews, physical and neurological examinations and an extensive neuropsychological battery. Results: Of these older subjects, 274 (9.2%) fulfilled all the AACD criteria, whereas 561 (18.8%) fulfilled only 3 of them (AACD-3). When the two groups diagnosed according to AACD criteria (AACD and AACD-3) were merged, the prevalence was 28.0% (28.3% for men, 27.6% for women). Two other groups of subjects were also identified: a) Subjects with Qbjective evidence of Cognitive Decline without cognitive complaints (OCD), 508 (17.0%), i.e., subjects with documented neuropsychological deficits, although neither subjects nor informants reported cognitive complaints; and b) Subjects with Cognitive Complaints without objective demonstrable cognitive deficits (CC), 44 (1.5%), i.e., subjects and/or informants reported cognitive complaints without evidence of neuropsychological deficits. Thus, taking into account the additional OCD group, a total of 1343 persons with cognitive impairment without dementia (45.0%) was identified. Conclusions: On the basis of our results, we estimate that 45% of our population-based Italian sample aged 65-84 years had some kind of cognitive deficits without dementia.
KW - Age-associated cognitive decline
KW - Dementia
KW - Elderly
KW - Italy
KW - Predementia syndromes
KW - Prevalence
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U2 - 10.3275/6970
DO - 10.3275/6970
M3 - Article
C2 - 20383053
AN - SCOPUS:79955390891
VL - 22
SP - 440
EP - 449
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
SN - 1594-0667
IS - 5-6
ER -