PREVALENCE OF ANTIBODIES TO HEPATITIS C VIRUS IN ITALIAN PATIENTS WITH HEPATOCELLULAR CARCINOMA

M. Colombo, Q. L. Choo, E. Del Ninno, N. Dioguardi, G. Kuo, M. F. Donato, M. A. Tommasini, M. Houghton

Research output: Contribution to journalArticle

Abstract

A sensitive radioimmunoassay was used to detect antibodies to hepatitis C virus (HCV) in patients with hepatocellular carcinoma and chronic hepatitis. HCV antibodies (anti-HCV) were detected in 86 of 132 patients with hepatocellular carcinoma with no relation to the presence or absence of hepatitis B surface antigen (HBsAg). The prevalence of anti-HCV was also high in patients with diseases thought to predispose to hepatocellular carcinoma, such as non-A, non-B chronic hepatitis and cirrhosis (74%). In HBsAg-negative patients with hepatocellular carcinoma the prevalence of anti-HCV was lower than that in patients with non-A, non-B chronic hepatitis (16% vs 55%); the prevalence of serum antibodies to hepatitis B core antigen (anti-HBc), a marker of hepatitis B virus infection, was 70% and 28%, respectively. In HBsAg-negative patients with hepatocellular carcinoma, anti-HCV and anti-HBc occurred together nearly three times as often as in patients with chronic hepatitis (54% vs 19%). These data indicate that, in Italy, HCV is an important factor associated with hepatocellular carcinoma and non-A, non-B chronic hepatitis.

Original languageEnglish
Pages (from-to)1006-1008
Number of pages3
JournalLancet
Volume334
Issue number8670
DOIs
Publication statusPublished - Oct 28 1989

ASJC Scopus subject areas

  • Medicine(all)

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    Colombo, M., Choo, Q. L., Del Ninno, E., Dioguardi, N., Kuo, G., Donato, M. F., Tommasini, M. A., & Houghton, M. (1989). PREVALENCE OF ANTIBODIES TO HEPATITIS C VIRUS IN ITALIAN PATIENTS WITH HEPATOCELLULAR CARCINOMA. Lancet, 334(8670), 1006-1008. https://doi.org/10.1016/S0140-6736(89)91016-7