Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke: An Italian case-control study

Maurizio Margaglione, Davide Seripa, Carolina Gravina, Elvira Grandone, Gennaro Vecchione, Giuseppe Cappucci, Giuseppe Merla, Sara Papa, Alfredo Postiglione, Giovanni D. Di Minno, Vito M. Fazio

Research output: Contribution to journalArticle

Abstract

Background and Purpose - The ε4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. Methods - The apoE ε genotypes of 100 patients with a documented history of ischemic stroke without clinically apparent dementia (stroke+) and 108 subjects without such history (stroke-) were determined. The relative frequency of the apoE alleles and genotypes was estimated in 398 healthy subjects aged

Original languageEnglish
Pages (from-to)399-403
Number of pages5
JournalStroke
Volume29
Issue number2
Publication statusPublished - 1998

Keywords

  • Apolipoprotein E
  • Risk factors
  • Stroke
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

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