Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke: An Italian case-control study

Maurizio Margaglione, Davide Seripa, Carolina Gravina, Elvira Grandone, Gennaro Vecchione, Giuseppe Cappucci, Giuseppe Merla, Sara Papa, Alfredo Postiglione, Giovanni D. Di Minno, Vito M. Fazio

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background and Purpose - The ε4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. Methods - The apoE ε genotypes of 100 patients with a documented history of ischemic stroke without clinically apparent dementia (stroke+) and 108 subjects without such history (stroke-) were determined. The relative frequency of the apoE alleles and genotypes was estimated in 398 healthy subjects aged

Original languageEnglish
Pages (from-to)399-403
Number of pages5
JournalStroke
Volume29
Issue number2
Publication statusPublished - 1998

Fingerprint

Apolipoproteins E
Survivors
Case-Control Studies
Healthy Volunteers
Stroke
Alleles
Genotype
Apolipoprotein E4
Dementia
Ischemia
History
Myocardial Infarction

Keywords

  • Apolipoprotein E
  • Risk factors
  • Stroke
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke : An Italian case-control study. / Margaglione, Maurizio; Seripa, Davide; Gravina, Carolina; Grandone, Elvira; Vecchione, Gennaro; Cappucci, Giuseppe; Merla, Giuseppe; Papa, Sara; Postiglione, Alfredo; Di Minno, Giovanni D.; Fazio, Vito M.

In: Stroke, Vol. 29, No. 2, 1998, p. 399-403.

Research output: Contribution to journalArticle

Margaglione, Maurizio ; Seripa, Davide ; Gravina, Carolina ; Grandone, Elvira ; Vecchione, Gennaro ; Cappucci, Giuseppe ; Merla, Giuseppe ; Papa, Sara ; Postiglione, Alfredo ; Di Minno, Giovanni D. ; Fazio, Vito M. / Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke : An Italian case-control study. In: Stroke. 1998 ; Vol. 29, No. 2. pp. 399-403.
@article{8f2ef5acf30c46759c3bfb30049b3ee0,
title = "Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke: An Italian case-control study",
abstract = "Background and Purpose - The ε4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. Methods - The apoE ε genotypes of 100 patients with a documented history of ischemic stroke without clinically apparent dementia (stroke+) and 108 subjects without such history (stroke-) were determined. The relative frequency of the apoE alleles and genotypes was estimated in 398 healthy subjects aged",
keywords = "Apolipoprotein E, Risk factors, Stroke, Thrombosis",
author = "Maurizio Margaglione and Davide Seripa and Carolina Gravina and Elvira Grandone and Gennaro Vecchione and Giuseppe Cappucci and Giuseppe Merla and Sara Papa and Alfredo Postiglione and {Di Minno}, {Giovanni D.} and Fazio, {Vito M.}",
year = "1998",
language = "English",
volume = "29",
pages = "399--403",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke

T2 - An Italian case-control study

AU - Margaglione, Maurizio

AU - Seripa, Davide

AU - Gravina, Carolina

AU - Grandone, Elvira

AU - Vecchione, Gennaro

AU - Cappucci, Giuseppe

AU - Merla, Giuseppe

AU - Papa, Sara

AU - Postiglione, Alfredo

AU - Di Minno, Giovanni D.

AU - Fazio, Vito M.

PY - 1998

Y1 - 1998

N2 - Background and Purpose - The ε4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. Methods - The apoE ε genotypes of 100 patients with a documented history of ischemic stroke without clinically apparent dementia (stroke+) and 108 subjects without such history (stroke-) were determined. The relative frequency of the apoE alleles and genotypes was estimated in 398 healthy subjects aged

AB - Background and Purpose - The ε4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. Methods - The apoE ε genotypes of 100 patients with a documented history of ischemic stroke without clinically apparent dementia (stroke+) and 108 subjects without such history (stroke-) were determined. The relative frequency of the apoE alleles and genotypes was estimated in 398 healthy subjects aged

KW - Apolipoprotein E

KW - Risk factors

KW - Stroke

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=0031909692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031909692&partnerID=8YFLogxK

M3 - Article

C2 - 9472880

AN - SCOPUS:0031909692

VL - 29

SP - 399

EP - 403

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 2

ER -