Prevalence of asthma-like symptoms with ageing

Debbie Jarvis, Roger Newson, Christer Janson, Angelo Corsico, Joachim Heinrich, Josep M. Anto, Michael J. Abramson, Anne Marie Kirsten, Jan Paul Zock, Roberto Bono, Pascal Demoly, Bénédicte Leynaert, Chantal Raherison, Isabelle Pin, Thorarinn Gislason, Rain Jogi, Vivi Schlunssen, Cecilie Svanes, John Watkins, Joost Weyler & 10 others Antonio Pereira-Vega, Isabel Urrutia, Jose A. Gullón, Bertil Forsberg, Nicole Probst-Hensch, H. Marike Boezen, Jesús Martinez-Moratalla Rovira, Simone Accordini, Roberto de Marco, Peter Burney

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy.

METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20-44 years (29 centres in 13 European countries and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates.

FINDINGS: Over 20 years the prevalence of 'wheeze' and 'wheeze in the absence of a cold' decreased (-2.4%, 95% CI -3.5 to -1.3%; -1.5%, 95% CI -2.4 to -0.6%, respectively) but the prevalence of asthma attacks, use of asthma medication and hay fever/nasal allergies increased (0.6%, 95% CI 0.1 to 1.11; 3.6%, 95% CI 3.0 to 4.2; 2.7%, 95% CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hay fever/nasal allergies at baseline.

INTERPRETATION: European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.

Original languageEnglish
Pages (from-to)37-48
Number of pages12
JournalThorax
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Asthma
Seasonal Allergic Rhinitis
Nose
Hypersensitivity
Smoking
European Union
Smoking Cessation
Health Surveys
Meta-Analysis
Therapeutics
Population

Keywords

  • Asthma Epidemiology

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Jarvis, D., Newson, R., Janson, C., Corsico, A., Heinrich, J., Anto, J. M., ... Burney, P. (2018). Prevalence of asthma-like symptoms with ageing. Thorax, 73(1), 37-48. https://doi.org/10.1136/thoraxjnl-2016-209596

Prevalence of asthma-like symptoms with ageing. / Jarvis, Debbie; Newson, Roger; Janson, Christer; Corsico, Angelo; Heinrich, Joachim; Anto, Josep M.; Abramson, Michael J.; Kirsten, Anne Marie; Zock, Jan Paul; Bono, Roberto; Demoly, Pascal; Leynaert, Bénédicte; Raherison, Chantal; Pin, Isabelle; Gislason, Thorarinn; Jogi, Rain; Schlunssen, Vivi; Svanes, Cecilie; Watkins, John; Weyler, Joost; Pereira-Vega, Antonio; Urrutia, Isabel; Gullón, Jose A.; Forsberg, Bertil; Probst-Hensch, Nicole; Boezen, H. Marike; Martinez-Moratalla Rovira, Jesús; Accordini, Simone; de Marco, Roberto; Burney, Peter.

In: Thorax, Vol. 73, No. 1, 01.01.2018, p. 37-48.

Research output: Contribution to journalArticle

Jarvis, D, Newson, R, Janson, C, Corsico, A, Heinrich, J, Anto, JM, Abramson, MJ, Kirsten, AM, Zock, JP, Bono, R, Demoly, P, Leynaert, B, Raherison, C, Pin, I, Gislason, T, Jogi, R, Schlunssen, V, Svanes, C, Watkins, J, Weyler, J, Pereira-Vega, A, Urrutia, I, Gullón, JA, Forsberg, B, Probst-Hensch, N, Boezen, HM, Martinez-Moratalla Rovira, J, Accordini, S, de Marco, R & Burney, P 2018, 'Prevalence of asthma-like symptoms with ageing', Thorax, vol. 73, no. 1, pp. 37-48. https://doi.org/10.1136/thoraxjnl-2016-209596
Jarvis D, Newson R, Janson C, Corsico A, Heinrich J, Anto JM et al. Prevalence of asthma-like symptoms with ageing. Thorax. 2018 Jan 1;73(1):37-48. https://doi.org/10.1136/thoraxjnl-2016-209596
Jarvis, Debbie ; Newson, Roger ; Janson, Christer ; Corsico, Angelo ; Heinrich, Joachim ; Anto, Josep M. ; Abramson, Michael J. ; Kirsten, Anne Marie ; Zock, Jan Paul ; Bono, Roberto ; Demoly, Pascal ; Leynaert, Bénédicte ; Raherison, Chantal ; Pin, Isabelle ; Gislason, Thorarinn ; Jogi, Rain ; Schlunssen, Vivi ; Svanes, Cecilie ; Watkins, John ; Weyler, Joost ; Pereira-Vega, Antonio ; Urrutia, Isabel ; Gullón, Jose A. ; Forsberg, Bertil ; Probst-Hensch, Nicole ; Boezen, H. Marike ; Martinez-Moratalla Rovira, Jesús ; Accordini, Simone ; de Marco, Roberto ; Burney, Peter. / Prevalence of asthma-like symptoms with ageing. In: Thorax. 2018 ; Vol. 73, No. 1. pp. 37-48.
@article{80e5c5e843ca4346bbc5e8a143d37b73,
title = "Prevalence of asthma-like symptoms with ageing",
abstract = "BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy.METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20-44 years (29 centres in 13 European countries and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates.FINDINGS: Over 20 years the prevalence of 'wheeze' and 'wheeze in the absence of a cold' decreased (-2.4{\%}, 95{\%} CI -3.5 to -1.3{\%}; -1.5{\%}, 95{\%} CI -2.4 to -0.6{\%}, respectively) but the prevalence of asthma attacks, use of asthma medication and hay fever/nasal allergies increased (0.6{\%}, 95{\%} CI 0.1 to 1.11; 3.6{\%}, 95{\%} CI 3.0 to 4.2; 2.7{\%}, 95{\%} CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hay fever/nasal allergies at baseline.INTERPRETATION: European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.",
keywords = "Asthma Epidemiology",
author = "Debbie Jarvis and Roger Newson and Christer Janson and Angelo Corsico and Joachim Heinrich and Anto, {Josep M.} and Abramson, {Michael J.} and Kirsten, {Anne Marie} and Zock, {Jan Paul} and Roberto Bono and Pascal Demoly and B{\'e}n{\'e}dicte Leynaert and Chantal Raherison and Isabelle Pin and Thorarinn Gislason and Rain Jogi and Vivi Schlunssen and Cecilie Svanes and John Watkins and Joost Weyler and Antonio Pereira-Vega and Isabel Urrutia and Gull{\'o}n, {Jose A.} and Bertil Forsberg and Nicole Probst-Hensch and Boezen, {H. Marike} and {Martinez-Moratalla Rovira}, Jes{\'u}s and Simone Accordini and {de Marco}, Roberto and Peter Burney",
year = "2018",
month = "1",
day = "1",
doi = "10.1136/thoraxjnl-2016-209596",
language = "English",
volume = "73",
pages = "37--48",
journal = "Thorax",
issn = "0040-6376",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - Prevalence of asthma-like symptoms with ageing

AU - Jarvis, Debbie

AU - Newson, Roger

AU - Janson, Christer

AU - Corsico, Angelo

AU - Heinrich, Joachim

AU - Anto, Josep M.

AU - Abramson, Michael J.

AU - Kirsten, Anne Marie

AU - Zock, Jan Paul

AU - Bono, Roberto

AU - Demoly, Pascal

AU - Leynaert, Bénédicte

AU - Raherison, Chantal

AU - Pin, Isabelle

AU - Gislason, Thorarinn

AU - Jogi, Rain

AU - Schlunssen, Vivi

AU - Svanes, Cecilie

AU - Watkins, John

AU - Weyler, Joost

AU - Pereira-Vega, Antonio

AU - Urrutia, Isabel

AU - Gullón, Jose A.

AU - Forsberg, Bertil

AU - Probst-Hensch, Nicole

AU - Boezen, H. Marike

AU - Martinez-Moratalla Rovira, Jesús

AU - Accordini, Simone

AU - de Marco, Roberto

AU - Burney, Peter

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy.METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20-44 years (29 centres in 13 European countries and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates.FINDINGS: Over 20 years the prevalence of 'wheeze' and 'wheeze in the absence of a cold' decreased (-2.4%, 95% CI -3.5 to -1.3%; -1.5%, 95% CI -2.4 to -0.6%, respectively) but the prevalence of asthma attacks, use of asthma medication and hay fever/nasal allergies increased (0.6%, 95% CI 0.1 to 1.11; 3.6%, 95% CI 3.0 to 4.2; 2.7%, 95% CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hay fever/nasal allergies at baseline.INTERPRETATION: European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.

AB - BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy.METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20-44 years (29 centres in 13 European countries and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates.FINDINGS: Over 20 years the prevalence of 'wheeze' and 'wheeze in the absence of a cold' decreased (-2.4%, 95% CI -3.5 to -1.3%; -1.5%, 95% CI -2.4 to -0.6%, respectively) but the prevalence of asthma attacks, use of asthma medication and hay fever/nasal allergies increased (0.6%, 95% CI 0.1 to 1.11; 3.6%, 95% CI 3.0 to 4.2; 2.7%, 95% CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hay fever/nasal allergies at baseline.INTERPRETATION: European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.

KW - Asthma Epidemiology

UR - http://www.scopus.com/inward/record.url?scp=85039065289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039065289&partnerID=8YFLogxK

U2 - 10.1136/thoraxjnl-2016-209596

DO - 10.1136/thoraxjnl-2016-209596

M3 - Article

VL - 73

SP - 37

EP - 48

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 1

ER -