Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus

S. Fineschi, M. O. Borghi, P. Riboldi, M. Gariglio, C. Buzio, S. Landolfo, L. Cebecauer, A. Tuchynova, J. Rovensky, P. L. Meroni

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Antibodies (Abs) against the structure specific recognition protein 1 (SSRP1) were reported in a small systemic lupus erythematosus (SLE) series but not in other systemic autoimmune diseases. The aim of the study was to confirm the selective presence of anti-SSRP1 Abs in a larger SLE series and to evaluate their relationship with disease activity and other immune markers. Anti-SSRP1 Abs were investigated by a 'home made' ELISA in: 120 SLE, 65 rheumatoid arthritis (RA), 51 systemic sclerosis (SSc), 23 Churg-Strauss syndrome (CSS) and 40 idiopathic autoimmune urticaria (IAU) patients and 190 healthy controls. Sera from MRL lpr/lpr and Balb-c mice were also tested. Anti-SSRP1 Abs were detected in 43 SLE (35.8%), nine SSc (17.6%), eight RA (12.3%), six IAU (15%), three CSS (13%) patients and five healthy controls (2.6%). Antibody prevalence and titers were significantly higher in SLE patients than in sera from both normal and disease controls. Anti-SSRP1 Ab activity was also detected in sera from MRL lpr/lpr but not Balb-c mice. The antibodies did not correlate with the disease activity evaluated as the ECLAM index score and were more prevalent in patients without renal involvement. No correlation was found with other serum autoantibodies. Our results confirm that anti-SSRP1 Abs are associated with but not specific for the lupus disease.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalLupus
Volume13
Issue number6
DOIs
Publication statusPublished - 2004

Fingerprint

Systemic Lupus Erythematosus
Autoantibodies
Antibodies
Proteins
Churg-Strauss Syndrome
Systemic Scleroderma
Urticaria
Serum
Rheumatoid Arthritis
Autoimmune Diseases
Biomarkers
Enzyme-Linked Immunosorbent Assay
Kidney

Keywords

  • Autoantibodies
  • SSRP1
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus. / Fineschi, S.; Borghi, M. O.; Riboldi, P.; Gariglio, M.; Buzio, C.; Landolfo, S.; Cebecauer, L.; Tuchynova, A.; Rovensky, J.; Meroni, P. L.

In: Lupus, Vol. 13, No. 6, 2004, p. 463-468.

Research output: Contribution to journalArticle

Fineschi, S, Borghi, MO, Riboldi, P, Gariglio, M, Buzio, C, Landolfo, S, Cebecauer, L, Tuchynova, A, Rovensky, J & Meroni, PL 2004, 'Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus', Lupus, vol. 13, no. 6, pp. 463-468. https://doi.org/10.1191/0961203304lu1049oa
Fineschi, S. ; Borghi, M. O. ; Riboldi, P. ; Gariglio, M. ; Buzio, C. ; Landolfo, S. ; Cebecauer, L. ; Tuchynova, A. ; Rovensky, J. ; Meroni, P. L. / Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus. In: Lupus. 2004 ; Vol. 13, No. 6. pp. 463-468.
@article{0e1d2a4fe99949faacb9923e28a09199,
title = "Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus",
abstract = "Antibodies (Abs) against the structure specific recognition protein 1 (SSRP1) were reported in a small systemic lupus erythematosus (SLE) series but not in other systemic autoimmune diseases. The aim of the study was to confirm the selective presence of anti-SSRP1 Abs in a larger SLE series and to evaluate their relationship with disease activity and other immune markers. Anti-SSRP1 Abs were investigated by a 'home made' ELISA in: 120 SLE, 65 rheumatoid arthritis (RA), 51 systemic sclerosis (SSc), 23 Churg-Strauss syndrome (CSS) and 40 idiopathic autoimmune urticaria (IAU) patients and 190 healthy controls. Sera from MRL lpr/lpr and Balb-c mice were also tested. Anti-SSRP1 Abs were detected in 43 SLE (35.8{\%}), nine SSc (17.6{\%}), eight RA (12.3{\%}), six IAU (15{\%}), three CSS (13{\%}) patients and five healthy controls (2.6{\%}). Antibody prevalence and titers were significantly higher in SLE patients than in sera from both normal and disease controls. Anti-SSRP1 Ab activity was also detected in sera from MRL lpr/lpr but not Balb-c mice. The antibodies did not correlate with the disease activity evaluated as the ECLAM index score and were more prevalent in patients without renal involvement. No correlation was found with other serum autoantibodies. Our results confirm that anti-SSRP1 Abs are associated with but not specific for the lupus disease.",
keywords = "Autoantibodies, SSRP1, Systemic lupus erythematosus",
author = "S. Fineschi and Borghi, {M. O.} and P. Riboldi and M. Gariglio and C. Buzio and S. Landolfo and L. Cebecauer and A. Tuchynova and J. Rovensky and Meroni, {P. L.}",
year = "2004",
doi = "10.1191/0961203304lu1049oa",
language = "English",
volume = "13",
pages = "463--468",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "6",

}

TY - JOUR

T1 - Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus

AU - Fineschi, S.

AU - Borghi, M. O.

AU - Riboldi, P.

AU - Gariglio, M.

AU - Buzio, C.

AU - Landolfo, S.

AU - Cebecauer, L.

AU - Tuchynova, A.

AU - Rovensky, J.

AU - Meroni, P. L.

PY - 2004

Y1 - 2004

N2 - Antibodies (Abs) against the structure specific recognition protein 1 (SSRP1) were reported in a small systemic lupus erythematosus (SLE) series but not in other systemic autoimmune diseases. The aim of the study was to confirm the selective presence of anti-SSRP1 Abs in a larger SLE series and to evaluate their relationship with disease activity and other immune markers. Anti-SSRP1 Abs were investigated by a 'home made' ELISA in: 120 SLE, 65 rheumatoid arthritis (RA), 51 systemic sclerosis (SSc), 23 Churg-Strauss syndrome (CSS) and 40 idiopathic autoimmune urticaria (IAU) patients and 190 healthy controls. Sera from MRL lpr/lpr and Balb-c mice were also tested. Anti-SSRP1 Abs were detected in 43 SLE (35.8%), nine SSc (17.6%), eight RA (12.3%), six IAU (15%), three CSS (13%) patients and five healthy controls (2.6%). Antibody prevalence and titers were significantly higher in SLE patients than in sera from both normal and disease controls. Anti-SSRP1 Ab activity was also detected in sera from MRL lpr/lpr but not Balb-c mice. The antibodies did not correlate with the disease activity evaluated as the ECLAM index score and were more prevalent in patients without renal involvement. No correlation was found with other serum autoantibodies. Our results confirm that anti-SSRP1 Abs are associated with but not specific for the lupus disease.

AB - Antibodies (Abs) against the structure specific recognition protein 1 (SSRP1) were reported in a small systemic lupus erythematosus (SLE) series but not in other systemic autoimmune diseases. The aim of the study was to confirm the selective presence of anti-SSRP1 Abs in a larger SLE series and to evaluate their relationship with disease activity and other immune markers. Anti-SSRP1 Abs were investigated by a 'home made' ELISA in: 120 SLE, 65 rheumatoid arthritis (RA), 51 systemic sclerosis (SSc), 23 Churg-Strauss syndrome (CSS) and 40 idiopathic autoimmune urticaria (IAU) patients and 190 healthy controls. Sera from MRL lpr/lpr and Balb-c mice were also tested. Anti-SSRP1 Abs were detected in 43 SLE (35.8%), nine SSc (17.6%), eight RA (12.3%), six IAU (15%), three CSS (13%) patients and five healthy controls (2.6%). Antibody prevalence and titers were significantly higher in SLE patients than in sera from both normal and disease controls. Anti-SSRP1 Ab activity was also detected in sera from MRL lpr/lpr but not Balb-c mice. The antibodies did not correlate with the disease activity evaluated as the ECLAM index score and were more prevalent in patients without renal involvement. No correlation was found with other serum autoantibodies. Our results confirm that anti-SSRP1 Abs are associated with but not specific for the lupus disease.

KW - Autoantibodies

KW - SSRP1

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=3142769084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142769084&partnerID=8YFLogxK

U2 - 10.1191/0961203304lu1049oa

DO - 10.1191/0961203304lu1049oa

M3 - Article

VL - 13

SP - 463

EP - 468

JO - Lupus

JF - Lupus

SN - 0961-2033

IS - 6

ER -