Prevalence of bacterial vaginosis and vaginal flora changes in peri- and postmenopausal women

Sabina Cauci, Silvia Driussi, Davide De Santo, Paola Penacchioni, Teresa Iannicelli, Paolo Lanzafame, Francesco De Seta, Franco Quadrifoglio, Domenico De Aloysio, Secondo Guaschino

Research output: Contribution to journalArticle

Abstract

Our aim was to evaluate the prevalence of bacterial vaginosis and decrease in lactobacillus colonization in women 40 years old or older in relation to menopausal status by evaluation of Gram-stained smears. A total of 1,486 smears from Italian Caucasian women aged 40 to 79 years were examined. Women were classified as follows: fertile (regular cycles) (n = 328), perimenopausal (irregular cycles) (n = 237), and postmenopausal (n = 921), including 331 women on estroprogestinic hormone replacement therapy (HRT). The prevalences of bacterial vaginosis (assessed as a Nugent score of ≥7) in fertile (9.8%) and perimenopausal (11.0%) women were not statistically different, whereas the prevalence was significantly lower overall in postmenopausal women (6.0%) (P = 0.02). Specifically, 6.3% of postmenopausal women without HRT and 5.4% of postmenopausal women with HRT were positive for bacterial vaginosis. The Nugent score system was not adequate for evaluating the normal and intermediate vaginal flora in women over the age of 40 years. High numbers of periand postmenopausal women had no lactobacilli and no bacterial -vaginosis-associated microorganisms. This nonpathological absence of lactobacilli in women with a Nugent score of 4 was scored as 4*, and this group was considered separately from the intermediate flora group. A score of 4* was obtained for 2.1% of fertile women, 11.4% of perimenopausal women, 44.1% of postmenopausal women without HRT, and 6.9% of postmenopausal women with HRT. The physiological reduction in lactobacillus colonization of the vagina in postmenopausal women does not cause an increase in bacterial-vaginosis prevalence. Reversion of lactobacillus flora to premenopausal levels due to HRT does not increase the prevalence of bacterial vaginosis in postmenopausal women.

Original languageEnglish
Pages (from-to)2147-2152
Number of pages6
JournalJournal of Clinical Microbiology
Volume40
Issue number6
DOIs
Publication statusPublished - 2002

    Fingerprint

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Cauci, S., Driussi, S., De Santo, D., Penacchioni, P., Iannicelli, T., Lanzafame, P., De Seta, F., Quadrifoglio, F., De Aloysio, D., & Guaschino, S. (2002). Prevalence of bacterial vaginosis and vaginal flora changes in peri- and postmenopausal women. Journal of Clinical Microbiology, 40(6), 2147-2152. https://doi.org/10.1128/JCM.40.6.2147-2152.2002