Abstract
Patients with pemphigus may produce antibodies against molecules other than the classical transmembranal ones. Recently, for example antibodies to 230 kDa antigens have been found in association with antibodies to intercellular substance. To better understand their prevalence, clinical correlates and prognostic significance of bands other than 130 and 160 kDa, we studied 67 pemphigus sera. About one-fourth of patients revealed multiple heterogeneous bands and 13% the 230 kDa band. When challenged with the recombinant protein rBP55, the carbossiterminal portion of bullous pemphigoid major antigen, all 230 kDa-positive-sera proved negative. Caution is to be recommended in interpreting pemphigus sera with a band migrating at the 230 kDa level.
| Original language | English |
|---|---|
| Pages (from-to) | 233-236 |
| Number of pages | 4 |
| Journal | Journal of the European Academy of Dermatology and Venereology |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1998 |
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Keywords
- Immunoblotting
- Multiple reactivity
- Pemphigus
ASJC Scopus subject areas
- Dermatology
- Infectious Diseases
Cite this
Prevalence of bands other than 160 and 130 kDa in pemphigus sera (a multicenter immunoblotting study). / Cozzani, E.; Parodi, A.; Rebora, A.
In: Journal of the European Academy of Dermatology and Venereology, Vol. 10, No. 3, 1998, p. 233-236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevalence of bands other than 160 and 130 kDa in pemphigus sera (a multicenter immunoblotting study)
AU - Cozzani, E.
AU - Parodi, A.
AU - Rebora, A.
PY - 1998
Y1 - 1998
N2 - Patients with pemphigus may produce antibodies against molecules other than the classical transmembranal ones. Recently, for example antibodies to 230 kDa antigens have been found in association with antibodies to intercellular substance. To better understand their prevalence, clinical correlates and prognostic significance of bands other than 130 and 160 kDa, we studied 67 pemphigus sera. About one-fourth of patients revealed multiple heterogeneous bands and 13% the 230 kDa band. When challenged with the recombinant protein rBP55, the carbossiterminal portion of bullous pemphigoid major antigen, all 230 kDa-positive-sera proved negative. Caution is to be recommended in interpreting pemphigus sera with a band migrating at the 230 kDa level.
AB - Patients with pemphigus may produce antibodies against molecules other than the classical transmembranal ones. Recently, for example antibodies to 230 kDa antigens have been found in association with antibodies to intercellular substance. To better understand their prevalence, clinical correlates and prognostic significance of bands other than 130 and 160 kDa, we studied 67 pemphigus sera. About one-fourth of patients revealed multiple heterogeneous bands and 13% the 230 kDa band. When challenged with the recombinant protein rBP55, the carbossiterminal portion of bullous pemphigoid major antigen, all 230 kDa-positive-sera proved negative. Caution is to be recommended in interpreting pemphigus sera with a band migrating at the 230 kDa level.
KW - Immunoblotting
KW - Multiple reactivity
KW - Pemphigus
UR - http://www.scopus.com/inward/record.url?scp=0031811230&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031811230&partnerID=8YFLogxK
U2 - 10.1016/S0926-9959(97)00176-1
DO - 10.1016/S0926-9959(97)00176-1
M3 - Article
VL - 10
SP - 233
EP - 236
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
SN - 0926-9959
IS - 3
ER -