Prevalence of bands other than 160 and 130 kDa in pemphigus sera (a multicenter immunoblotting study)

E. Cozzani, A. Parodi, A. Rebora

Research output: Contribution to journalArticle

Abstract

Patients with pemphigus may produce antibodies against molecules other than the classical transmembranal ones. Recently, for example antibodies to 230 kDa antigens have been found in association with antibodies to intercellular substance. To better understand their prevalence, clinical correlates and prognostic significance of bands other than 130 and 160 kDa, we studied 67 pemphigus sera. About one-fourth of patients revealed multiple heterogeneous bands and 13% the 230 kDa band. When challenged with the recombinant protein rBP55, the carbossiterminal portion of bullous pemphigoid major antigen, all 230 kDa-positive-sera proved negative. Caution is to be recommended in interpreting pemphigus sera with a band migrating at the 230 kDa level.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalJournal of the European Academy of Dermatology and Venereology
Volume10
Issue number3
DOIs
Publication statusPublished - 1998

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Keywords

  • Immunoblotting
  • Multiple reactivity
  • Pemphigus

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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