Prevalence of beta and gamma human papillomaviruses in the anal canal of men who have sex with men is influenced by HIV status

Montserrat Torres, Tarik Gheit, Sandrine McKay-Chopin, Carmen Rodríguez, Jorge Del Romero, Raffaele Filotico, Maria Gabriella Doná, Marta Ortiz, Massimo Tommasino

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Mucosal high-risk human papillomavirus (HPV) types benefit differently from the immunocompromised status of the host. So far it is not known whether a similar scenario holds for the large group of the β and γ cutaneous HPV types that appear to be present at several anatomical sites. Methods: The presence of β (. n=. 43) and γ (. n=. 30) HPVs in the anal samples of 66 HIV-positive and 153 HIV-negative anonymized men who have sex with men (MSM) was determined by multiplex PCR, using type-specific primers and bead-based hybridization (Luminex technology). Results: The prevalence of β and γ HPV infection was 65.6% and 68.2%, respectively, among HIV-positive MSM and 59.1% and 57.7%, respectively, among HIV-negative MSM. β-2 and γ-10 were found to be the most prevalent species in both groups. The prevalence of infection with HPV types of the species β-1 (. P=. 0.02), β-3 (. P=. 0.002), γ-6 (. P=. 0.002), and γ-7 (. P=. 0.02) was higher in HIV-positive than HIV-negative men. In contrast, the β-2 species was equally distributed in the two groups, while the γ-10 species was slightly affected by HIV status. Conclusions: These findings provide evidence that impairment of the host's immune surveillance impacts β and γ HPV infections differently.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalJournal of Clinical Virology
Volume67
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Anal canal
  • HIV status
  • β and γ HPVs

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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