Prevalence of etravirine (ETR)-RAMs at NNRTI failure and predictors of resistance to ETR in a large Italian resistance database (ARCA)

S. Rusconi, F. Adorni, B. Bruzzone, A. Di Biagio, G. Meini, A. Callegaro, G. Punzi, E. Boeri, M. Pecorari, L. Monno, N. Gianotti, L. Butini, L. Galli, E. Polilli, M. Galli

Research output: Contribution to journalArticle

Abstract

The prevalence of drug resistance associated with the failure of non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens and the predictors of resistance to Etravirine (ETR) were assessed in 2854 subjects: 39 3, Tibotec (TBT) >2 and enhanced MGR (ENH) ≥4) emerged in the paediatric population. Multivariate analysis revealed an increased risk of developing TBT >2 for NNRTI exposure, ENH ≥4 for NNRTI and EFV exposure in paediatric subjects; NVP exposure and higher (≥3.5 log10) HIV-RNA values for all three algorithms in adult subjects, whereas CD4 ≥ 200/μL appeared to be protective. The risk of being ETR resistant was more than doubled for paediatric vs. adult subjects, probably due to a more extensive use of NNRTI and an incomplete virological control.

Original languageEnglish
JournalClinical Microbiology and Infection
Volume19
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

etravirine
Reverse Transcriptase Inhibitors
Databases
Pediatrics
Drug Resistance
Multivariate Analysis
HIV
RNA
Population

Keywords

  • Drug resistance
  • Etravirine
  • Genotype
  • HIV-1

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Prevalence of etravirine (ETR)-RAMs at NNRTI failure and predictors of resistance to ETR in a large Italian resistance database (ARCA). / Rusconi, S.; Adorni, F.; Bruzzone, B.; Di Biagio, A.; Meini, G.; Callegaro, A.; Punzi, G.; Boeri, E.; Pecorari, M.; Monno, L.; Gianotti, N.; Butini, L.; Galli, L.; Polilli, E.; Galli, M.

In: Clinical Microbiology and Infection, Vol. 19, No. 10, 10.2013.

Research output: Contribution to journalArticle

Rusconi, S, Adorni, F, Bruzzone, B, Di Biagio, A, Meini, G, Callegaro, A, Punzi, G, Boeri, E, Pecorari, M, Monno, L, Gianotti, N, Butini, L, Galli, L, Polilli, E & Galli, M 2013, 'Prevalence of etravirine (ETR)-RAMs at NNRTI failure and predictors of resistance to ETR in a large Italian resistance database (ARCA)', Clinical Microbiology and Infection, vol. 19, no. 10. https://doi.org/10.1111/1469-0691.12229
Rusconi, S. ; Adorni, F. ; Bruzzone, B. ; Di Biagio, A. ; Meini, G. ; Callegaro, A. ; Punzi, G. ; Boeri, E. ; Pecorari, M. ; Monno, L. ; Gianotti, N. ; Butini, L. ; Galli, L. ; Polilli, E. ; Galli, M. / Prevalence of etravirine (ETR)-RAMs at NNRTI failure and predictors of resistance to ETR in a large Italian resistance database (ARCA). In: Clinical Microbiology and Infection. 2013 ; Vol. 19, No. 10.
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