Prevalence of Helicobacter pylori infection in male patients with osteoporosis and controls

N. Figura, L. Gennari, D. Merlotti, C. Lenzi, S. Campagna, B. Franci, B. Lucani, L. Trabalzini, L. Bianciardi, C. Gonnelli, A. Santucci, A. Nut

Research output: Contribution to journalArticle

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Abstract

Cytokines that regulate bone turnover (tumor necrosis factor-α, interleukin-6, etc.) may influence the pathogenesis of skeleton disorders, such as osteoporosis. Since Helicobacter pylori infection increases the systemic levels of inflammatory cytokines, we investigated the possibility that this infection increases the risk of developing osteoporosis and affects the bone metabolism in a group of male patients with osteoporosis. We examined 80 osteoporotic male patients and 160 controls for serum antibodies to H. pylori and the CagA protein and determined, in patients alone, the most important biochemical and instrumental parameters of the disease. Fifty-one patients (63.7%) and 107 controls (66.8%) were seropositive for H. pylori infection (nonsignificant); 30 infected patients (58.8%) and 43 infected controls (40.1%) were positive for anti-CagA antibodies (P = 0.028; OR = 2.13). Levels of estradiol in infected CagA-positive patients were significantly lower than in infected CagA-negative patients (28.5 [SD = 10.18] vs. 39.5 [SD = 14.50] pg/ml; P = 0.002) and uninfected patients (35.2 [SD = 12.7] pg/ml; P = 0.028). Levels of urinary cross-laps(a marker of bone resorption) were increased in patients infected by CagA-positive strains compared to patients infected by CagA-negative strains (282.9 [SD = 103.8] vs. 210.5 [SD = 150.1] μ g/mmol; P = 0.048) and uninfected patients (204.3 [SD = 130.1] μ g/mmol; P = 0.016). Differences among uninfected and infected patients, independent of CagA status, were observed for other markers of bone turnover, but they did not reach statistical significance. Infection by CagA-positive H. pylori strains is more prevalent in men with osteoporosis, who show reduced systemic levels of estrogens and increased bone turnover. H. pylori infection by strains expressing CagA may therefore be considered a risk factor for osteoporisis in men.

Original languageEnglish
Pages (from-to)847-852
Number of pages6
JournalDigestive Diseases and Sciences
Volume50
Issue number5
DOIs
Publication statusPublished - May 2005

Fingerprint

Helicobacter Infections
Helicobacter pylori
Osteoporosis
Bone Remodeling
Cytokines
Bone Resorption
Infection
Skeleton
Anti-Idiotypic Antibodies
Estradiol
Interleukin-6
Estrogens
Tumor Necrosis Factor-alpha
Bone and Bones

Keywords

  • Bone turnover
  • CagA protein
  • Cytokines
  • Estrogens
  • Helicobacter pylori
  • Osteoporosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Figura, N., Gennari, L., Merlotti, D., Lenzi, C., Campagna, S., Franci, B., ... Nut, A. (2005). Prevalence of Helicobacter pylori infection in male patients with osteoporosis and controls. Digestive Diseases and Sciences, 50(5), 847-852. https://doi.org/10.1007/s10620-005-2651-4

Prevalence of Helicobacter pylori infection in male patients with osteoporosis and controls. / Figura, N.; Gennari, L.; Merlotti, D.; Lenzi, C.; Campagna, S.; Franci, B.; Lucani, B.; Trabalzini, L.; Bianciardi, L.; Gonnelli, C.; Santucci, A.; Nut, A.

In: Digestive Diseases and Sciences, Vol. 50, No. 5, 05.2005, p. 847-852.

Research output: Contribution to journalArticle

Figura, N, Gennari, L, Merlotti, D, Lenzi, C, Campagna, S, Franci, B, Lucani, B, Trabalzini, L, Bianciardi, L, Gonnelli, C, Santucci, A & Nut, A 2005, 'Prevalence of Helicobacter pylori infection in male patients with osteoporosis and controls', Digestive Diseases and Sciences, vol. 50, no. 5, pp. 847-852. https://doi.org/10.1007/s10620-005-2651-4
Figura, N. ; Gennari, L. ; Merlotti, D. ; Lenzi, C. ; Campagna, S. ; Franci, B. ; Lucani, B. ; Trabalzini, L. ; Bianciardi, L. ; Gonnelli, C. ; Santucci, A. ; Nut, A. / Prevalence of Helicobacter pylori infection in male patients with osteoporosis and controls. In: Digestive Diseases and Sciences. 2005 ; Vol. 50, No. 5. pp. 847-852.
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