Prevalence of hepatitis B and C viruses and human immunodeficiency virus infections in women of reproductive age

V. Puro, E. Girardi, G. Ippolito, E. Lo Presti, A. Benedetto, S. Zaniratti, V. Giannini, C. Gioia, S. Natili, G. Tossini, P. Pomini, N. Rizzi, P. Tellini

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the prevalence of hepatitis B and C viruses, and human immunodeficiency virus infections in women of reproductive age attending a health care system. Design: Prospective cross-sectional study. Setting: Public Obstetric Clinic and Service for Pre- and Perinatal Prevention of Infectious Diseases, Rome, Latium Region, Italy. Subjects: 1142 women attending our centres consecutively for delivery, miscarriage, voluntary interruption of pregnancy or screening for pre- and perinatal prevention of infectious diseases. Interventions: Serum samples, collected after informed consent over a period of 2 months, were tested for hepatitis B virus markers (anti-HBc and HBsAg) by enzyme linked immunosorbent assay (ELISA), for antibodies against hepatitis C virus (by ELISA and, if positive, by RIBA) and for human immunodeficiency virus antibodies (by ELISA and, if positive by Western blot). Results: The seroprevalence of hepatitis B virus was 14.4% (95% CI Poisson distribution 12.2-16.5) for anti-HBc and 1.6% (95% CI 0.9-2.5) for HBsAg. Antibodies against hepatitis C virus were detected by ELISA in 2.4% (CI 1.6-3.5) and by first generation RIBA in 0.9% (CI 0.4-1.6). Human immunodeficiency virus seroprevalence was 1.0% (CI 0.5-1.7). No significant differences were observed by age or by reason for attending. Conclusions: Women attending our centres have a higher prevalence of hepatitis B virus, hepatitis C virus and human immunodeficiency virus infection than those observed in our country in larger national surveys of newborn babies, in reproductive-aged women or in other selected low-risk groups such as blood donors. This could be due to the attendance of women at increased risk such as drug addicts. The information has the additional value of emphasizing the need for adherence by health care personnel, to the recommendations issued for the prevention of occupational infections.

Original languageEnglish
Pages (from-to)598-600
Number of pages3
JournalBritish Journal of Obstetrics and Gynaecology
Volume99
Issue number7
Publication statusPublished - 1992

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Virus Diseases
Hepatitis B virus
Hepacivirus
HIV
Enzyme-Linked Immunosorbent Assay
Hepatitis C Antibodies
Seroepidemiologic Studies
Hepatitis B Surface Antigens
Communicable Diseases
Poisson Distribution
Delivery of Health Care
Spontaneous Abortion
Drug Users
Blood Donors
Informed Consent
Prenatal Diagnosis
Health Personnel
Italy
Obstetrics
Cross-Sectional Studies

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Prevalence of hepatitis B and C viruses and human immunodeficiency virus infections in women of reproductive age. / Puro, V.; Girardi, E.; Ippolito, G.; Lo Presti, E.; Benedetto, A.; Zaniratti, S.; Giannini, V.; Gioia, C.; Natili, S.; Tossini, G.; Pomini, P.; Rizzi, N.; Tellini, P.

In: British Journal of Obstetrics and Gynaecology, Vol. 99, No. 7, 1992, p. 598-600.

Research output: Contribution to journalArticle

Puro, V, Girardi, E, Ippolito, G, Lo Presti, E, Benedetto, A, Zaniratti, S, Giannini, V, Gioia, C, Natili, S, Tossini, G, Pomini, P, Rizzi, N & Tellini, P 1992, 'Prevalence of hepatitis B and C viruses and human immunodeficiency virus infections in women of reproductive age', British Journal of Obstetrics and Gynaecology, vol. 99, no. 7, pp. 598-600.
Puro, V. ; Girardi, E. ; Ippolito, G. ; Lo Presti, E. ; Benedetto, A. ; Zaniratti, S. ; Giannini, V. ; Gioia, C. ; Natili, S. ; Tossini, G. ; Pomini, P. ; Rizzi, N. ; Tellini, P. / Prevalence of hepatitis B and C viruses and human immunodeficiency virus infections in women of reproductive age. In: British Journal of Obstetrics and Gynaecology. 1992 ; Vol. 99, No. 7. pp. 598-600.
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abstract = "Objective: To determine the prevalence of hepatitis B and C viruses, and human immunodeficiency virus infections in women of reproductive age attending a health care system. Design: Prospective cross-sectional study. Setting: Public Obstetric Clinic and Service for Pre- and Perinatal Prevention of Infectious Diseases, Rome, Latium Region, Italy. Subjects: 1142 women attending our centres consecutively for delivery, miscarriage, voluntary interruption of pregnancy or screening for pre- and perinatal prevention of infectious diseases. Interventions: Serum samples, collected after informed consent over a period of 2 months, were tested for hepatitis B virus markers (anti-HBc and HBsAg) by enzyme linked immunosorbent assay (ELISA), for antibodies against hepatitis C virus (by ELISA and, if positive, by RIBA) and for human immunodeficiency virus antibodies (by ELISA and, if positive by Western blot). Results: The seroprevalence of hepatitis B virus was 14.4{\%} (95{\%} CI Poisson distribution 12.2-16.5) for anti-HBc and 1.6{\%} (95{\%} CI 0.9-2.5) for HBsAg. Antibodies against hepatitis C virus were detected by ELISA in 2.4{\%} (CI 1.6-3.5) and by first generation RIBA in 0.9{\%} (CI 0.4-1.6). Human immunodeficiency virus seroprevalence was 1.0{\%} (CI 0.5-1.7). No significant differences were observed by age or by reason for attending. Conclusions: Women attending our centres have a higher prevalence of hepatitis B virus, hepatitis C virus and human immunodeficiency virus infection than those observed in our country in larger national surveys of newborn babies, in reproductive-aged women or in other selected low-risk groups such as blood donors. This could be due to the attendance of women at increased risk such as drug addicts. The information has the additional value of emphasizing the need for adherence by health care personnel, to the recommendations issued for the prevention of occupational infections.",
author = "V. Puro and E. Girardi and G. Ippolito and {Lo Presti}, E. and A. Benedetto and S. Zaniratti and V. Giannini and C. Gioia and S. Natili and G. Tossini and P. Pomini and N. Rizzi and P. Tellini",
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AU - Puro, V.

AU - Girardi, E.

AU - Ippolito, G.

AU - Lo Presti, E.

AU - Benedetto, A.

AU - Zaniratti, S.

AU - Giannini, V.

AU - Gioia, C.

AU - Natili, S.

AU - Tossini, G.

AU - Pomini, P.

AU - Rizzi, N.

AU - Tellini, P.

PY - 1992

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N2 - Objective: To determine the prevalence of hepatitis B and C viruses, and human immunodeficiency virus infections in women of reproductive age attending a health care system. Design: Prospective cross-sectional study. Setting: Public Obstetric Clinic and Service for Pre- and Perinatal Prevention of Infectious Diseases, Rome, Latium Region, Italy. Subjects: 1142 women attending our centres consecutively for delivery, miscarriage, voluntary interruption of pregnancy or screening for pre- and perinatal prevention of infectious diseases. Interventions: Serum samples, collected after informed consent over a period of 2 months, were tested for hepatitis B virus markers (anti-HBc and HBsAg) by enzyme linked immunosorbent assay (ELISA), for antibodies against hepatitis C virus (by ELISA and, if positive, by RIBA) and for human immunodeficiency virus antibodies (by ELISA and, if positive by Western blot). Results: The seroprevalence of hepatitis B virus was 14.4% (95% CI Poisson distribution 12.2-16.5) for anti-HBc and 1.6% (95% CI 0.9-2.5) for HBsAg. Antibodies against hepatitis C virus were detected by ELISA in 2.4% (CI 1.6-3.5) and by first generation RIBA in 0.9% (CI 0.4-1.6). Human immunodeficiency virus seroprevalence was 1.0% (CI 0.5-1.7). No significant differences were observed by age or by reason for attending. Conclusions: Women attending our centres have a higher prevalence of hepatitis B virus, hepatitis C virus and human immunodeficiency virus infection than those observed in our country in larger national surveys of newborn babies, in reproductive-aged women or in other selected low-risk groups such as blood donors. This could be due to the attendance of women at increased risk such as drug addicts. The information has the additional value of emphasizing the need for adherence by health care personnel, to the recommendations issued for the prevention of occupational infections.

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