Prevalence of hepatitis C virus infection in different population groups in southern Italy

M. Montella, A. Crispo, M. Grimaldi, C. Angeletti, A. Amore, D. Ronga, M. Sabbatici, A. Pisani, D. Spiteri, D. Serraino

Research output: Contribution to journalArticlepeer-review


Background: A cross-sectional investigation was carried out between 2000 and 2002 to assess the prevalence of hepatitis C virus infection (HCV) in Naples, southern Italy. Patients and Methods: Five groups of individuals were investigated, two at Low risk and three at high risk for HCV infection. Blood sample sera were collected among 5,391 individuals (4,059 men and 1,332 women): 1,972 general practitioner (GP) patients and 781 employees of the National Cancer Institute (NCI) of Naples (low-risk groups); 524 male prisoners, 1,436 intravenous drug users (IDUs) and 678 hemodialysis patients (high-risk groups). Results: Overall HCV seropositivity rates ranged from 6.4% among employees of the NCI to 37.4% among male prisoners. HCV infection tended to generally increase with age, but in IDUs and in male prisoners the upward trend leveled off at 50 years of age. As compared to GP patients, IDUs (both sexes) and male prisoners had a nearly 6-fold increased risk of HCV infection, while HCV was nearly 3-fold more common among hemodialysis patients. Employees of NCI were at reduced risk of HCV infection, particularly women (odds ratio = 0.3). Conclusion: The study findings confirmed the high risk for HCV infection in IDUs and identified other population groups in southern Italy that should be offered HCV screening and counselling given the servere implications of HCV infection on health.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
Issue number1
Publication statusPublished - Feb 2005

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)


Dive into the research topics of 'Prevalence of hepatitis C virus infection in different population groups in southern Italy'. Together they form a unique fingerprint.

Cite this