Prevalence of hepatitis C virus infection in lymphoproliferative diseases other than B-cell non-Hodgkin's lymphoma, and in myeloproliferative diseases: An Italian multi-center case-control study

Elvira Bianco, Fabrizio Marcucci, Alfonso Mele, Pellegrino Musto, Rodolfo Cotichini, Maria Grazia Sanpaolo, Emilio Iannitto, Amalia De Renzo, Bruno Martino, Giorgina Specchia, Marco Montanaro, Anna Maria Barbui, Rosa Nieddu, Livio Pagano, Maria Rapicetta, Silvia Franceschi, Franco Mandelli, Alessandro Pulsoni

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Abstract

Background and Objectives. Infection with hepatitis C virus (HCV) is associated with type II mixed cryoglobulinemia (MC), a lymphoproliferative disorder which, in some patients, evolves into overt B-cell non-Hodgkin's lymphoma (B-NHL). Recently, the association between HCV infection and B-NHL, which had long been controversial, was confirmed in a large case-control study. Little knowledge is, however, available on possible associations between HCV infection and other lymphoid or myeloid malignancies. The present study was set up in order to investigate this aspect. Design and Methods. The study was conducted in hematology departments of ten hospitals in different Italian cities. The cases consisted of consecutive patients with a new diagnosis of T-NHL, Hodgkin's disease (HD), chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), multiple myeloma (MM), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). The controls were patients in other departments of the same hospitals. HCV infection was investigated by testing for HCV antibodies and HCV-RNA in serum samples. Results. The prevalence of HCV infection was not higher in patients with HD (3.2%, 5 out of 157 cases) or MM (4.7%, 5 out of 107) than in controls. On the other hand, it was consistently higher in T-NHL (13.8%, 4 out of 30), CLL (9.0%, 9 out of 100), ALL (7.6%, 5 out of 54), AML (7.9%, 11 out of 140), and CML (12.2%, 6 out of 49) patients. These patient groups were not, however, large enough to render the results statistically significant. Interpretation and Conclusions. Our data suggest that HCV infection may be associated not only with B-NHL but also with some other lymphoid and myeloid malignancies.

Original languageEnglish
Pages (from-to)70-76
Number of pages7
JournalHaematologica
Volume89
Issue number1
Publication statusPublished - Jan 2004

Fingerprint

B-Cell Lymphoma
Virus Diseases
Hepacivirus
Non-Hodgkin's Lymphoma
Case-Control Studies
Hospital Departments
B-Cell Chronic Lymphocytic Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Multiple Myeloma
Hodgkin Disease
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Cryoglobulinemia
Hepatitis C Antibodies
Lymphoproliferative Disorders
Hematology
Neoplasms
RNA
Infection
Serum

Keywords

  • HCV
  • Hepatitis C virus
  • Lymphoproliferative diseases
  • Myeloproliferative diseases

ASJC Scopus subject areas

  • Hematology

Cite this

Prevalence of hepatitis C virus infection in lymphoproliferative diseases other than B-cell non-Hodgkin's lymphoma, and in myeloproliferative diseases : An Italian multi-center case-control study. / Bianco, Elvira; Marcucci, Fabrizio; Mele, Alfonso; Musto, Pellegrino; Cotichini, Rodolfo; Sanpaolo, Maria Grazia; Iannitto, Emilio; De Renzo, Amalia; Martino, Bruno; Specchia, Giorgina; Montanaro, Marco; Barbui, Anna Maria; Nieddu, Rosa; Pagano, Livio; Rapicetta, Maria; Franceschi, Silvia; Mandelli, Franco; Pulsoni, Alessandro.

In: Haematologica, Vol. 89, No. 1, 01.2004, p. 70-76.

Research output: Contribution to journalArticle

Bianco, E, Marcucci, F, Mele, A, Musto, P, Cotichini, R, Sanpaolo, MG, Iannitto, E, De Renzo, A, Martino, B, Specchia, G, Montanaro, M, Barbui, AM, Nieddu, R, Pagano, L, Rapicetta, M, Franceschi, S, Mandelli, F & Pulsoni, A 2004, 'Prevalence of hepatitis C virus infection in lymphoproliferative diseases other than B-cell non-Hodgkin's lymphoma, and in myeloproliferative diseases: An Italian multi-center case-control study', Haematologica, vol. 89, no. 1, pp. 70-76.
Bianco, Elvira ; Marcucci, Fabrizio ; Mele, Alfonso ; Musto, Pellegrino ; Cotichini, Rodolfo ; Sanpaolo, Maria Grazia ; Iannitto, Emilio ; De Renzo, Amalia ; Martino, Bruno ; Specchia, Giorgina ; Montanaro, Marco ; Barbui, Anna Maria ; Nieddu, Rosa ; Pagano, Livio ; Rapicetta, Maria ; Franceschi, Silvia ; Mandelli, Franco ; Pulsoni, Alessandro. / Prevalence of hepatitis C virus infection in lymphoproliferative diseases other than B-cell non-Hodgkin's lymphoma, and in myeloproliferative diseases : An Italian multi-center case-control study. In: Haematologica. 2004 ; Vol. 89, No. 1. pp. 70-76.
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abstract = "Background and Objectives. Infection with hepatitis C virus (HCV) is associated with type II mixed cryoglobulinemia (MC), a lymphoproliferative disorder which, in some patients, evolves into overt B-cell non-Hodgkin's lymphoma (B-NHL). Recently, the association between HCV infection and B-NHL, which had long been controversial, was confirmed in a large case-control study. Little knowledge is, however, available on possible associations between HCV infection and other lymphoid or myeloid malignancies. The present study was set up in order to investigate this aspect. Design and Methods. The study was conducted in hematology departments of ten hospitals in different Italian cities. The cases consisted of consecutive patients with a new diagnosis of T-NHL, Hodgkin's disease (HD), chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), multiple myeloma (MM), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). The controls were patients in other departments of the same hospitals. HCV infection was investigated by testing for HCV antibodies and HCV-RNA in serum samples. Results. The prevalence of HCV infection was not higher in patients with HD (3.2{\%}, 5 out of 157 cases) or MM (4.7{\%}, 5 out of 107) than in controls. On the other hand, it was consistently higher in T-NHL (13.8{\%}, 4 out of 30), CLL (9.0{\%}, 9 out of 100), ALL (7.6{\%}, 5 out of 54), AML (7.9{\%}, 11 out of 140), and CML (12.2{\%}, 6 out of 49) patients. These patient groups were not, however, large enough to render the results statistically significant. Interpretation and Conclusions. Our data suggest that HCV infection may be associated not only with B-NHL but also with some other lymphoid and myeloid malignancies.",
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T1 - Prevalence of hepatitis C virus infection in lymphoproliferative diseases other than B-cell non-Hodgkin's lymphoma, and in myeloproliferative diseases

T2 - An Italian multi-center case-control study

AU - Bianco, Elvira

AU - Marcucci, Fabrizio

AU - Mele, Alfonso

AU - Musto, Pellegrino

AU - Cotichini, Rodolfo

AU - Sanpaolo, Maria Grazia

AU - Iannitto, Emilio

AU - De Renzo, Amalia

AU - Martino, Bruno

AU - Specchia, Giorgina

AU - Montanaro, Marco

AU - Barbui, Anna Maria

AU - Nieddu, Rosa

AU - Pagano, Livio

AU - Rapicetta, Maria

AU - Franceschi, Silvia

AU - Mandelli, Franco

AU - Pulsoni, Alessandro

PY - 2004/1

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N2 - Background and Objectives. Infection with hepatitis C virus (HCV) is associated with type II mixed cryoglobulinemia (MC), a lymphoproliferative disorder which, in some patients, evolves into overt B-cell non-Hodgkin's lymphoma (B-NHL). Recently, the association between HCV infection and B-NHL, which had long been controversial, was confirmed in a large case-control study. Little knowledge is, however, available on possible associations between HCV infection and other lymphoid or myeloid malignancies. The present study was set up in order to investigate this aspect. Design and Methods. The study was conducted in hematology departments of ten hospitals in different Italian cities. The cases consisted of consecutive patients with a new diagnosis of T-NHL, Hodgkin's disease (HD), chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), multiple myeloma (MM), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). The controls were patients in other departments of the same hospitals. HCV infection was investigated by testing for HCV antibodies and HCV-RNA in serum samples. Results. The prevalence of HCV infection was not higher in patients with HD (3.2%, 5 out of 157 cases) or MM (4.7%, 5 out of 107) than in controls. On the other hand, it was consistently higher in T-NHL (13.8%, 4 out of 30), CLL (9.0%, 9 out of 100), ALL (7.6%, 5 out of 54), AML (7.9%, 11 out of 140), and CML (12.2%, 6 out of 49) patients. These patient groups were not, however, large enough to render the results statistically significant. Interpretation and Conclusions. Our data suggest that HCV infection may be associated not only with B-NHL but also with some other lymphoid and myeloid malignancies.

AB - Background and Objectives. Infection with hepatitis C virus (HCV) is associated with type II mixed cryoglobulinemia (MC), a lymphoproliferative disorder which, in some patients, evolves into overt B-cell non-Hodgkin's lymphoma (B-NHL). Recently, the association between HCV infection and B-NHL, which had long been controversial, was confirmed in a large case-control study. Little knowledge is, however, available on possible associations between HCV infection and other lymphoid or myeloid malignancies. The present study was set up in order to investigate this aspect. Design and Methods. The study was conducted in hematology departments of ten hospitals in different Italian cities. The cases consisted of consecutive patients with a new diagnosis of T-NHL, Hodgkin's disease (HD), chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), multiple myeloma (MM), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). The controls were patients in other departments of the same hospitals. HCV infection was investigated by testing for HCV antibodies and HCV-RNA in serum samples. Results. The prevalence of HCV infection was not higher in patients with HD (3.2%, 5 out of 157 cases) or MM (4.7%, 5 out of 107) than in controls. On the other hand, it was consistently higher in T-NHL (13.8%, 4 out of 30), CLL (9.0%, 9 out of 100), ALL (7.6%, 5 out of 54), AML (7.9%, 11 out of 140), and CML (12.2%, 6 out of 49) patients. These patient groups were not, however, large enough to render the results statistically significant. Interpretation and Conclusions. Our data suggest that HCV infection may be associated not only with B-NHL but also with some other lymphoid and myeloid malignancies.

KW - HCV

KW - Hepatitis C virus

KW - Lymphoproliferative diseases

KW - Myeloproliferative diseases

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