Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up

C. Mandelli, D. Conte, R. Barbera, T. Masullo, S. Pistoso, G. P. Aimo, L. Cesarini, M. Fraguelli, G. P. Lorini, P. A. Bianchi

Research output: Contribution to journalArticle

Abstract

In a series of 646 heroin addicts anti-HIV was detected in 428 (66.2%) and HBsAg in 53 (8.2%). Forty-eight (90.5%) of the latter had concomitant chronic HDV infection. Markers of past HBV infection were found in 481 (74.4%). The prevalence of anti-HIV was significantly higher in the 534 subjects with HBV markers than in the other 112 without markers (69.8% versus 49.1%, p <0.001). Of the 266 anti-HIV positive subjects followed for 3-48 months (median 12), nine progressed from no disease to persistent generalized lymphadenopathy (PGL), 52 from PGL to AIDS-related complex (ARC) or AIDS (30 and 22 cases respectively), and six from ARC to AIDS. Baseline T4 + cell count was significantly lower and reduction during follow-up significantly greater in heroin addicts with disease progression than in those without.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalEuropean Journal of Epidemiology
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 1991

Keywords

  • AIDS
  • AIDS-related complex (ARC)
  • Hepatitis B
  • Hepatitis delta
  • Heroin users
  • HIV

ASJC Scopus subject areas

  • Epidemiology

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    Mandelli, C., Conte, D., Barbera, R., Masullo, T., Pistoso, S., Aimo, G. P., Cesarini, L., Fraguelli, M., Lorini, G. P., & Bianchi, P. A. (1991). Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up. European Journal of Epidemiology, 7(1), 83-87. https://doi.org/10.1007/BF00221346