Prevalence of HNPCC in a series of consecutive patients on the first endoscopic diagnosis of colorectal cancer: A multicenter study

G. Riegler, A. Savastano, F. Selvaggi, R. Ciociano, R. Martino, G. Riccio, R. Iorio, G. Ponti, R. Carratú, P. Borgheresi, G. De Filippo, G. B. Rossi, A. M. Tempesta, G. D. De Palma, C. Catanzano, P. Russo, M. A. Bianco, A. Piscitelli, V. Di Carlo, V. BaldiP. Avagliano, F. Guardascione, G. Petrelli, P. Di Giorgio, L. De Luca, E. D'Avenia, D. Cattaneo, F. Montanaro, T. Maisto, E. Parente, R. Vincenti, O. Saffiotti, D. Di Cesare, M. Bozzi, M. Beatrice

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and Study Aims: It is difficult to measure the prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in geographical areas that do not have tumor registers, as is the case in the present study, and it was therefore decided to assess the prevalence in Italy using different methods. Patients and Methods: The pedigree was established for 485 of 501 colorectal cancer patients diagnosed with colorectal carcinomas. Patients were included consecutively in 13 gastroenterology centers; they had not taken part in prevention examinations. Information was collected regarding the neoplastic pathology observed in the families, confirmed in 90% of cases among 3515 first-degree relatives and in 79.5% of cases among 7068 second-degree relatives. Results: In the 3515 first-degree relatives (1002 parents, 1560 siblings and 953 children), 61 colorectal carcinomas, 29 carcinomas in the digestive tract outside the colon, and 99 carcinomas in other locations were reported. Only five of the 485 patients (1%) satisfied the Amsterdam criteria (three cancers, two of which were in first-degree relatives in different generations and one in a relative younger than 50). When broadening the criteria that we are proposing (satisfying only two of the three Amsterdam criteria), the prevalence would increase to 3% (15 cases). Conclusions: Modifying the criteria makes it easier to identify new mutations or confirm the existence of those already known, as well as allowing preventative treatment in relatives who are apparently healthy.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalEndoscopy
Volume31
Issue number5
DOIs
Publication statusPublished - 1999

Fingerprint

Multicenter Studies
Colorectal Neoplasms
Carcinoma
Gastroenterology
Pedigree
Italy
Gastrointestinal Tract
Siblings
Neoplasms
Colon
Parents
Pathology
Mutation

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Riegler, G., Savastano, A., Selvaggi, F., Ciociano, R., Martino, R., Riccio, G., ... Beatrice, M. (1999). Prevalence of HNPCC in a series of consecutive patients on the first endoscopic diagnosis of colorectal cancer: A multicenter study. Endoscopy, 31(5), 337-341. https://doi.org/10.1055/s-1999-30

Prevalence of HNPCC in a series of consecutive patients on the first endoscopic diagnosis of colorectal cancer : A multicenter study. / Riegler, G.; Savastano, A.; Selvaggi, F.; Ciociano, R.; Martino, R.; Riccio, G.; Iorio, R.; Ponti, G.; Carratú, R.; Borgheresi, P.; De Filippo, G.; Rossi, G. B.; Tempesta, A. M.; De Palma, G. D.; Catanzano, C.; Russo, P.; Bianco, M. A.; Piscitelli, A.; Di Carlo, V.; Baldi, V.; Avagliano, P.; Guardascione, F.; Petrelli, G.; Di Giorgio, P.; De Luca, L.; D'Avenia, E.; Cattaneo, D.; Montanaro, F.; Maisto, T.; Parente, E.; Vincenti, R.; Saffiotti, O.; Di Cesare, D.; Bozzi, M.; Beatrice, M.

In: Endoscopy, Vol. 31, No. 5, 1999, p. 337-341.

Research output: Contribution to journalArticle

Riegler, G, Savastano, A, Selvaggi, F, Ciociano, R, Martino, R, Riccio, G, Iorio, R, Ponti, G, Carratú, R, Borgheresi, P, De Filippo, G, Rossi, GB, Tempesta, AM, De Palma, GD, Catanzano, C, Russo, P, Bianco, MA, Piscitelli, A, Di Carlo, V, Baldi, V, Avagliano, P, Guardascione, F, Petrelli, G, Di Giorgio, P, De Luca, L, D'Avenia, E, Cattaneo, D, Montanaro, F, Maisto, T, Parente, E, Vincenti, R, Saffiotti, O, Di Cesare, D, Bozzi, M & Beatrice, M 1999, 'Prevalence of HNPCC in a series of consecutive patients on the first endoscopic diagnosis of colorectal cancer: A multicenter study', Endoscopy, vol. 31, no. 5, pp. 337-341. https://doi.org/10.1055/s-1999-30
Riegler, G. ; Savastano, A. ; Selvaggi, F. ; Ciociano, R. ; Martino, R. ; Riccio, G. ; Iorio, R. ; Ponti, G. ; Carratú, R. ; Borgheresi, P. ; De Filippo, G. ; Rossi, G. B. ; Tempesta, A. M. ; De Palma, G. D. ; Catanzano, C. ; Russo, P. ; Bianco, M. A. ; Piscitelli, A. ; Di Carlo, V. ; Baldi, V. ; Avagliano, P. ; Guardascione, F. ; Petrelli, G. ; Di Giorgio, P. ; De Luca, L. ; D'Avenia, E. ; Cattaneo, D. ; Montanaro, F. ; Maisto, T. ; Parente, E. ; Vincenti, R. ; Saffiotti, O. ; Di Cesare, D. ; Bozzi, M. ; Beatrice, M. / Prevalence of HNPCC in a series of consecutive patients on the first endoscopic diagnosis of colorectal cancer : A multicenter study. In: Endoscopy. 1999 ; Vol. 31, No. 5. pp. 337-341.
@article{c979bbbef5844ec88da2f17c132a28f9,
title = "Prevalence of HNPCC in a series of consecutive patients on the first endoscopic diagnosis of colorectal cancer: A multicenter study",
abstract = "Background and Study Aims: It is difficult to measure the prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in geographical areas that do not have tumor registers, as is the case in the present study, and it was therefore decided to assess the prevalence in Italy using different methods. Patients and Methods: The pedigree was established for 485 of 501 colorectal cancer patients diagnosed with colorectal carcinomas. Patients were included consecutively in 13 gastroenterology centers; they had not taken part in prevention examinations. Information was collected regarding the neoplastic pathology observed in the families, confirmed in 90{\%} of cases among 3515 first-degree relatives and in 79.5{\%} of cases among 7068 second-degree relatives. Results: In the 3515 first-degree relatives (1002 parents, 1560 siblings and 953 children), 61 colorectal carcinomas, 29 carcinomas in the digestive tract outside the colon, and 99 carcinomas in other locations were reported. Only five of the 485 patients (1{\%}) satisfied the Amsterdam criteria (three cancers, two of which were in first-degree relatives in different generations and one in a relative younger than 50). When broadening the criteria that we are proposing (satisfying only two of the three Amsterdam criteria), the prevalence would increase to 3{\%} (15 cases). Conclusions: Modifying the criteria makes it easier to identify new mutations or confirm the existence of those already known, as well as allowing preventative treatment in relatives who are apparently healthy.",
author = "G. Riegler and A. Savastano and F. Selvaggi and R. Ciociano and R. Martino and G. Riccio and R. Iorio and G. Ponti and R. Carrat{\'u} and P. Borgheresi and {De Filippo}, G. and Rossi, {G. B.} and Tempesta, {A. M.} and {De Palma}, {G. D.} and C. Catanzano and P. Russo and Bianco, {M. A.} and A. Piscitelli and {Di Carlo}, V. and V. Baldi and P. Avagliano and F. Guardascione and G. Petrelli and {Di Giorgio}, P. and {De Luca}, L. and E. D'Avenia and D. Cattaneo and F. Montanaro and T. Maisto and E. Parente and R. Vincenti and O. Saffiotti and {Di Cesare}, D. and M. Bozzi and M. Beatrice",
year = "1999",
doi = "10.1055/s-1999-30",
language = "English",
volume = "31",
pages = "337--341",
journal = "Endoscopy",
issn = "0013-726X",
publisher = "Georg Thieme Verlag",
number = "5",

}

TY - JOUR

T1 - Prevalence of HNPCC in a series of consecutive patients on the first endoscopic diagnosis of colorectal cancer

T2 - A multicenter study

AU - Riegler, G.

AU - Savastano, A.

AU - Selvaggi, F.

AU - Ciociano, R.

AU - Martino, R.

AU - Riccio, G.

AU - Iorio, R.

AU - Ponti, G.

AU - Carratú, R.

AU - Borgheresi, P.

AU - De Filippo, G.

AU - Rossi, G. B.

AU - Tempesta, A. M.

AU - De Palma, G. D.

AU - Catanzano, C.

AU - Russo, P.

AU - Bianco, M. A.

AU - Piscitelli, A.

AU - Di Carlo, V.

AU - Baldi, V.

AU - Avagliano, P.

AU - Guardascione, F.

AU - Petrelli, G.

AU - Di Giorgio, P.

AU - De Luca, L.

AU - D'Avenia, E.

AU - Cattaneo, D.

AU - Montanaro, F.

AU - Maisto, T.

AU - Parente, E.

AU - Vincenti, R.

AU - Saffiotti, O.

AU - Di Cesare, D.

AU - Bozzi, M.

AU - Beatrice, M.

PY - 1999

Y1 - 1999

N2 - Background and Study Aims: It is difficult to measure the prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in geographical areas that do not have tumor registers, as is the case in the present study, and it was therefore decided to assess the prevalence in Italy using different methods. Patients and Methods: The pedigree was established for 485 of 501 colorectal cancer patients diagnosed with colorectal carcinomas. Patients were included consecutively in 13 gastroenterology centers; they had not taken part in prevention examinations. Information was collected regarding the neoplastic pathology observed in the families, confirmed in 90% of cases among 3515 first-degree relatives and in 79.5% of cases among 7068 second-degree relatives. Results: In the 3515 first-degree relatives (1002 parents, 1560 siblings and 953 children), 61 colorectal carcinomas, 29 carcinomas in the digestive tract outside the colon, and 99 carcinomas in other locations were reported. Only five of the 485 patients (1%) satisfied the Amsterdam criteria (three cancers, two of which were in first-degree relatives in different generations and one in a relative younger than 50). When broadening the criteria that we are proposing (satisfying only two of the three Amsterdam criteria), the prevalence would increase to 3% (15 cases). Conclusions: Modifying the criteria makes it easier to identify new mutations or confirm the existence of those already known, as well as allowing preventative treatment in relatives who are apparently healthy.

AB - Background and Study Aims: It is difficult to measure the prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in geographical areas that do not have tumor registers, as is the case in the present study, and it was therefore decided to assess the prevalence in Italy using different methods. Patients and Methods: The pedigree was established for 485 of 501 colorectal cancer patients diagnosed with colorectal carcinomas. Patients were included consecutively in 13 gastroenterology centers; they had not taken part in prevention examinations. Information was collected regarding the neoplastic pathology observed in the families, confirmed in 90% of cases among 3515 first-degree relatives and in 79.5% of cases among 7068 second-degree relatives. Results: In the 3515 first-degree relatives (1002 parents, 1560 siblings and 953 children), 61 colorectal carcinomas, 29 carcinomas in the digestive tract outside the colon, and 99 carcinomas in other locations were reported. Only five of the 485 patients (1%) satisfied the Amsterdam criteria (three cancers, two of which were in first-degree relatives in different generations and one in a relative younger than 50). When broadening the criteria that we are proposing (satisfying only two of the three Amsterdam criteria), the prevalence would increase to 3% (15 cases). Conclusions: Modifying the criteria makes it easier to identify new mutations or confirm the existence of those already known, as well as allowing preventative treatment in relatives who are apparently healthy.

UR - http://www.scopus.com/inward/record.url?scp=0032988385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032988385&partnerID=8YFLogxK

U2 - 10.1055/s-1999-30

DO - 10.1055/s-1999-30

M3 - Article

C2 - 10433040

AN - SCOPUS:0032988385

VL - 31

SP - 337

EP - 341

JO - Endoscopy

JF - Endoscopy

SN - 0013-726X

IS - 5

ER -