Prevalence of HTLV-III/LAV antibodies in Italian asymptomatic hemophiliacs given commercial concentrates of factors VIII and IX

P. Verani, G. Mariani, P. M. Mannucci, G. De Rossi, L. Nicoletti, F. Titti, E. Falcione, D. Pasqualetti, M. Ammassari, A. Gringeri

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Abstract

The prevalence of HTLV-III/LAV antibodies was evaluated in 222 Italian asymptomatic hemophiliacs treated exclusively with commercial factor concentrates made with American plasma. An increase of HTLV-III/LAV seropositivity from 1983 to 1985 was evident. This was independent of the type of hemophilia (A or B) but directly correlated to the amount of concentrate administered in the previoous year. Immunological data (T4 and T8 lymphocyte subsets) were evaluated in relation to seropositivity to HTLV-III/LAV. The presence of antibodies was found to be significantly associated with a low T4/T8 ratio and to a reduced T4 subpopulation, whereas increased levels of T8 lymphocytes correlated weakly with seropositivity. Data from 47 hemophiliacs tested both in 1984 and 1985 showed that 100% of those negative in 1984 and highly transfused in the previous year seroconverted up to 1985, whereas 33% of those not highly transfused did so.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalJournal of Medical Virology
Volume19
Issue number2
Publication statusPublished - 1986

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CD8-Positive T-Lymphocytes
HIV Seropositivity
HIV Antibodies
Factor VIII
CD4-Positive T-Lymphocytes
Hemophilia B
CD4-CD8 Ratio
Lymphocyte Subsets
Hemophilia A
HIV
Antibodies
prothrombin complex concentrates

ASJC Scopus subject areas

  • Virology

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Prevalence of HTLV-III/LAV antibodies in Italian asymptomatic hemophiliacs given commercial concentrates of factors VIII and IX. / Verani, P.; Mariani, G.; Mannucci, P. M.; De Rossi, G.; Nicoletti, L.; Titti, F.; Falcione, E.; Pasqualetti, D.; Ammassari, M.; Gringeri, A.

In: Journal of Medical Virology, Vol. 19, No. 2, 1986, p. 143-149.

Research output: Contribution to journalArticle

Verani, P, Mariani, G, Mannucci, PM, De Rossi, G, Nicoletti, L, Titti, F, Falcione, E, Pasqualetti, D, Ammassari, M & Gringeri, A 1986, 'Prevalence of HTLV-III/LAV antibodies in Italian asymptomatic hemophiliacs given commercial concentrates of factors VIII and IX', Journal of Medical Virology, vol. 19, no. 2, pp. 143-149.
Verani, P. ; Mariani, G. ; Mannucci, P. M. ; De Rossi, G. ; Nicoletti, L. ; Titti, F. ; Falcione, E. ; Pasqualetti, D. ; Ammassari, M. ; Gringeri, A. / Prevalence of HTLV-III/LAV antibodies in Italian asymptomatic hemophiliacs given commercial concentrates of factors VIII and IX. In: Journal of Medical Virology. 1986 ; Vol. 19, No. 2. pp. 143-149.
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abstract = "The prevalence of HTLV-III/LAV antibodies was evaluated in 222 Italian asymptomatic hemophiliacs treated exclusively with commercial factor concentrates made with American plasma. An increase of HTLV-III/LAV seropositivity from 1983 to 1985 was evident. This was independent of the type of hemophilia (A or B) but directly correlated to the amount of concentrate administered in the previoous year. Immunological data (T4 and T8 lymphocyte subsets) were evaluated in relation to seropositivity to HTLV-III/LAV. The presence of antibodies was found to be significantly associated with a low T4/T8 ratio and to a reduced T4 subpopulation, whereas increased levels of T8 lymphocytes correlated weakly with seropositivity. Data from 47 hemophiliacs tested both in 1984 and 1985 showed that 100{\%} of those negative in 1984 and highly transfused in the previous year seroconverted up to 1985, whereas 33{\%} of those not highly transfused did so.",
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AU - Verani, P.

AU - Mariani, G.

AU - Mannucci, P. M.

AU - De Rossi, G.

AU - Nicoletti, L.

AU - Titti, F.

AU - Falcione, E.

AU - Pasqualetti, D.

AU - Ammassari, M.

AU - Gringeri, A.

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AB - The prevalence of HTLV-III/LAV antibodies was evaluated in 222 Italian asymptomatic hemophiliacs treated exclusively with commercial factor concentrates made with American plasma. An increase of HTLV-III/LAV seropositivity from 1983 to 1985 was evident. This was independent of the type of hemophilia (A or B) but directly correlated to the amount of concentrate administered in the previoous year. Immunological data (T4 and T8 lymphocyte subsets) were evaluated in relation to seropositivity to HTLV-III/LAV. The presence of antibodies was found to be significantly associated with a low T4/T8 ratio and to a reduced T4 subpopulation, whereas increased levels of T8 lymphocytes correlated weakly with seropositivity. Data from 47 hemophiliacs tested both in 1984 and 1985 showed that 100% of those negative in 1984 and highly transfused in the previous year seroconverted up to 1985, whereas 33% of those not highly transfused did so.

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