Prevalence of human herpesvirus (HHV)-8 infection among carriers of cardiovascular disease

F. Carletti, C. Mandolini, A. Rossi, M. R. Capobianchi, Maria Clotilde Borgia

Research output: Contribution to journalArticle

Abstract

Infectious agents, such as herpesviruses, have been hypothesized to be involved in development of atheromatous plaque. The study aim was to evaluate the possibility that HHV-8 infection could be an additional risk factor for the establishment of cardiovascular disease. HHV-8 seroprevalence was determined by immunofluorescence in a population of cardiovascular disease patients (n=50) as compared to an age- and sex-matched group of control subjects (n=47); HHV-8 genome was detected in DNA extracted from circulating PBMC and from atheromatous lesions by PCR with primers specific for the minor virus capsid gene (ORF 26). The seroprevalence of HHV-8 was significantly increased in the patients as compared to the control population, while the presence of HHV-8 genome was observed in PBMC from 2 patients and 1 control. Virus-specific DNA was found in 2 out of 4 atheromatous plaques. The higher seroprevalence in patients suffering from vascular diseases as compared to age-and sex-matched controls suggests that HHV-8 infection could be an additional risk factor for the establishment of cardiovascular disease, although the data on the persistence of viral DNA in PBMC or in the arterial lesions are too exiguous to definitively support this hypothesis. More extensive studies are needed to define the exact role of HHV-8 infection in the establishment and progression of atheromatous lesion.

Original languageEnglish
Pages (from-to)110-113
Number of pages4
JournalJournal of Biological Regulators and Homeostatic Agents
Volume16
Issue number2
Publication statusPublished - 2002

Keywords

  • Atherosclerosis
  • Atherosclerotic plaque
  • Coronary artery disease
  • Herpesviruses
  • HHV-8

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Prevalence of human herpesvirus (HHV)-8 infection among carriers of cardiovascular disease'. Together they form a unique fingerprint.

  • Cite this