Prevalence of human papilloma virus type 5 DNA in lesional and non-lesional skin scales of Italian plaque-type psoriatic patients

Association with disease severity

G. Prignano, C. Ferraro, A. Mussi, F. Stivali, E. Trento, V. Bordignon, E. Crescimbeni, G. Salvati, A. M. Degener, Franco Ameglio

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Human papilloma virus type 5 (HPV-5) has been associated closely with psoriatic skin in Polish patients, while findings from other countries have indicated a more limited prevalence. The results of the present study, in which a type-specific nested PCR was used, indicated that scales of plaque-type psoriatic skin from 54 Italian patients had a high prevalence (74.1%) of HPV-5 DNA in lesional. areas, and a reduced prevalence (33.3%) in non-lesional skin (33.3%), compared to 0% of 20 healthy subjects and 3.6% in the lesional areas of 28 patients with various other dermatological diseases. Individuals negative for HPV-5 DNA had a less severe disease. No correlation was found between the presence of HPV DNA and a patient's age or sex. The data demonstrated a statistically significant association between psoriasis and HPV-5, although results in other geographical areas suggest variable virus spread or ethnic variation in virus colonisation.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalClinical Microbiology and Infection
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Papillomaviridae
Skin
DNA
Viruses
Psoriasis
Healthy Volunteers
Polymerase Chain Reaction

Keywords

  • HPV-5
  • Human papilloma virus
  • Nested PCR
  • PASI score
  • Psoriasis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Prevalence of human papilloma virus type 5 DNA in lesional and non-lesional skin scales of Italian plaque-type psoriatic patients : Association with disease severity. / Prignano, G.; Ferraro, C.; Mussi, A.; Stivali, F.; Trento, E.; Bordignon, V.; Crescimbeni, E.; Salvati, G.; Degener, A. M.; Ameglio, Franco.

In: Clinical Microbiology and Infection, Vol. 11, No. 1, 01.2005, p. 47-51.

Research output: Contribution to journalArticle

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