Prevalence of Hypertension in Children with Early-Stage ADPKD

Laura Massella, Djalila Mekahli, Dušan Paripović, Larisa Prikhodina, Nathalie Godefroid, Anna Niemirska, Ayşe Ağbaş, Karolina Kalicka, Augustina Jankauskiene, Malgorzata Mizerska-Wasiak, Alberto Caldas Afonso, Rémi Salomon, Georges Deschênes, Gema Ariceta, Z Birsin Özçakar, Ana Teixeira, Ali Duzova, Jérôme Harambat, Tomáš Seeman, Gabriela HrčkováAdrian Catalin Lungu, Svetlana Papizh, Amira Peco-Antic, Stéphanie De Rechter, Ugo Giordano, Marietta Kirchner, Teresa Lutz, Franz Schaefer, Olivier Devuyst, Elke Wühl, Francesco Emma

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitoring is the preferred method to diagnose hypertension in pediatrics, data in children with autosomal dominant polycystic kidney disease are limited.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our retrospective multicenter study was conducted to collect ambulatory BP monitoring recordings from patients with autosomal dominant polycystic kidney disease age <18 years old. Basic anthropometric parameters as well as data on kidney function, BP treatment, and kidney ultrasound were also collected.

RESULTS: Data from 310 children with autosomal dominant polycystic kidney disease with a mean age of 11.5±4.1 years old were collected at 22 European centers. At the time when ambulatory BP monitoring was performed, 95% of children had normal kidney function. Reference data for ambulatory BP monitoring were available for 292 patients. The prevalence rates of children with hypertension and/or those who were treated with antihypertensive drugs were 31%, 42%, and 35% during daytime, nighttime, or the entire 24-hour cycle, respectively. In addition, 52% of participants lacked a physiologic nocturnal BP dipping, and 18% had isolated nocturnal hypertension. Logistic regression analysis showed a significant association between a categorical cyst score that was calculated on the basis of the number of cysts >1 cm per kidney and daytime hypertension (odds ratio, 1.70; 95% confidence interval, 1.21 to 2.4; P=0.002), nighttime hypertension (odds ratio, 1.31; 95% confidence interval, 1.05 to 1.63; P=0.02), or 24-hour hypertension (odds ratio, 1.39; 95% confidence interval, 1.08 to 1.81; P=0.01). Kidney length, expressed as SD score, was also significantly associated with nighttime hypertension (odds ratio, 1.23; 95% confidence interval, 1.06 to 1.42; P=0.10).

CONCLUSIONS: These data indicate high prevalence of hypertension in children with autosomal dominant polycystic kidney disease starting at young ages.

Original languageEnglish
Pages (from-to)874-883
Number of pages10
JournalClinical journal of the American Society of Nephrology : CJASN
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 7 2018

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Autosomal Dominant Polycystic Kidney
Hypertension
Odds Ratio
Confidence Intervals
Ambulatory Monitoring
Kidney
Kidney Diseases
Multicenter Studies
Signs and Symptoms
Retrospective Studies
Pediatrics

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Prevalence of Hypertension in Children with Early-Stage ADPKD. / Massella, Laura; Mekahli, Djalila; Paripović, Dušan; Prikhodina, Larisa; Godefroid, Nathalie; Niemirska, Anna; Ağbaş, Ayşe; Kalicka, Karolina; Jankauskiene, Augustina; Mizerska-Wasiak, Malgorzata; Afonso, Alberto Caldas; Salomon, Rémi; Deschênes, Georges; Ariceta, Gema; Özçakar, Z Birsin; Teixeira, Ana; Duzova, Ali; Harambat, Jérôme; Seeman, Tomáš; Hrčková, Gabriela; Lungu, Adrian Catalin; Papizh, Svetlana; Peco-Antic, Amira; De Rechter, Stéphanie; Giordano, Ugo; Kirchner, Marietta; Lutz, Teresa; Schaefer, Franz; Devuyst, Olivier; Wühl, Elke; Emma, Francesco.

In: Clinical journal of the American Society of Nephrology : CJASN, Vol. 13, No. 6, 07.06.2018, p. 874-883.

Research output: Contribution to journalArticle

Massella, L, Mekahli, D, Paripović, D, Prikhodina, L, Godefroid, N, Niemirska, A, Ağbaş, A, Kalicka, K, Jankauskiene, A, Mizerska-Wasiak, M, Afonso, AC, Salomon, R, Deschênes, G, Ariceta, G, Özçakar, ZB, Teixeira, A, Duzova, A, Harambat, J, Seeman, T, Hrčková, G, Lungu, AC, Papizh, S, Peco-Antic, A, De Rechter, S, Giordano, U, Kirchner, M, Lutz, T, Schaefer, F, Devuyst, O, Wühl, E & Emma, F 2018, 'Prevalence of Hypertension in Children with Early-Stage ADPKD', Clinical journal of the American Society of Nephrology : CJASN, vol. 13, no. 6, pp. 874-883. https://doi.org/10.2215/CJN.11401017
Massella, Laura ; Mekahli, Djalila ; Paripović, Dušan ; Prikhodina, Larisa ; Godefroid, Nathalie ; Niemirska, Anna ; Ağbaş, Ayşe ; Kalicka, Karolina ; Jankauskiene, Augustina ; Mizerska-Wasiak, Malgorzata ; Afonso, Alberto Caldas ; Salomon, Rémi ; Deschênes, Georges ; Ariceta, Gema ; Özçakar, Z Birsin ; Teixeira, Ana ; Duzova, Ali ; Harambat, Jérôme ; Seeman, Tomáš ; Hrčková, Gabriela ; Lungu, Adrian Catalin ; Papizh, Svetlana ; Peco-Antic, Amira ; De Rechter, Stéphanie ; Giordano, Ugo ; Kirchner, Marietta ; Lutz, Teresa ; Schaefer, Franz ; Devuyst, Olivier ; Wühl, Elke ; Emma, Francesco. / Prevalence of Hypertension in Children with Early-Stage ADPKD. In: Clinical journal of the American Society of Nephrology : CJASN. 2018 ; Vol. 13, No. 6. pp. 874-883.
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title = "Prevalence of Hypertension in Children with Early-Stage ADPKD",
abstract = "BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitoring is the preferred method to diagnose hypertension in pediatrics, data in children with autosomal dominant polycystic kidney disease are limited.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our retrospective multicenter study was conducted to collect ambulatory BP monitoring recordings from patients with autosomal dominant polycystic kidney disease age <18 years old. Basic anthropometric parameters as well as data on kidney function, BP treatment, and kidney ultrasound were also collected.RESULTS: Data from 310 children with autosomal dominant polycystic kidney disease with a mean age of 11.5±4.1 years old were collected at 22 European centers. At the time when ambulatory BP monitoring was performed, 95{\%} of children had normal kidney function. Reference data for ambulatory BP monitoring were available for 292 patients. The prevalence rates of children with hypertension and/or those who were treated with antihypertensive drugs were 31{\%}, 42{\%}, and 35{\%} during daytime, nighttime, or the entire 24-hour cycle, respectively. In addition, 52{\%} of participants lacked a physiologic nocturnal BP dipping, and 18{\%} had isolated nocturnal hypertension. Logistic regression analysis showed a significant association between a categorical cyst score that was calculated on the basis of the number of cysts >1 cm per kidney and daytime hypertension (odds ratio, 1.70; 95{\%} confidence interval, 1.21 to 2.4; P=0.002), nighttime hypertension (odds ratio, 1.31; 95{\%} confidence interval, 1.05 to 1.63; P=0.02), or 24-hour hypertension (odds ratio, 1.39; 95{\%} confidence interval, 1.08 to 1.81; P=0.01). Kidney length, expressed as SD score, was also significantly associated with nighttime hypertension (odds ratio, 1.23; 95{\%} confidence interval, 1.06 to 1.42; P=0.10).CONCLUSIONS: These data indicate high prevalence of hypertension in children with autosomal dominant polycystic kidney disease starting at young ages.",
author = "Laura Massella and Djalila Mekahli and Dušan Paripović and Larisa Prikhodina and Nathalie Godefroid and Anna Niemirska and Ayşe Ağbaş and Karolina Kalicka and Augustina Jankauskiene and Malgorzata Mizerska-Wasiak and Afonso, {Alberto Caldas} and R{\'e}mi Salomon and Georges Desch{\^e}nes and Gema Ariceta and {\"O}z{\cc}akar, {Z Birsin} and Ana Teixeira and Ali Duzova and J{\'e}r{\^o}me Harambat and Tom{\'a}š Seeman and Gabriela Hrčkov{\'a} and Lungu, {Adrian Catalin} and Svetlana Papizh and Amira Peco-Antic and {De Rechter}, St{\'e}phanie and Ugo Giordano and Marietta Kirchner and Teresa Lutz and Franz Schaefer and Olivier Devuyst and Elke W{\"u}hl and Francesco Emma",
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language = "English",
volume = "13",
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TY - JOUR

T1 - Prevalence of Hypertension in Children with Early-Stage ADPKD

AU - Massella, Laura

AU - Mekahli, Djalila

AU - Paripović, Dušan

AU - Prikhodina, Larisa

AU - Godefroid, Nathalie

AU - Niemirska, Anna

AU - Ağbaş, Ayşe

AU - Kalicka, Karolina

AU - Jankauskiene, Augustina

AU - Mizerska-Wasiak, Malgorzata

AU - Afonso, Alberto Caldas

AU - Salomon, Rémi

AU - Deschênes, Georges

AU - Ariceta, Gema

AU - Özçakar, Z Birsin

AU - Teixeira, Ana

AU - Duzova, Ali

AU - Harambat, Jérôme

AU - Seeman, Tomáš

AU - Hrčková, Gabriela

AU - Lungu, Adrian Catalin

AU - Papizh, Svetlana

AU - Peco-Antic, Amira

AU - De Rechter, Stéphanie

AU - Giordano, Ugo

AU - Kirchner, Marietta

AU - Lutz, Teresa

AU - Schaefer, Franz

AU - Devuyst, Olivier

AU - Wühl, Elke

AU - Emma, Francesco

N1 - Copyright © 2018 by the American Society of Nephrology.

PY - 2018/6/7

Y1 - 2018/6/7

N2 - BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitoring is the preferred method to diagnose hypertension in pediatrics, data in children with autosomal dominant polycystic kidney disease are limited.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our retrospective multicenter study was conducted to collect ambulatory BP monitoring recordings from patients with autosomal dominant polycystic kidney disease age <18 years old. Basic anthropometric parameters as well as data on kidney function, BP treatment, and kidney ultrasound were also collected.RESULTS: Data from 310 children with autosomal dominant polycystic kidney disease with a mean age of 11.5±4.1 years old were collected at 22 European centers. At the time when ambulatory BP monitoring was performed, 95% of children had normal kidney function. Reference data for ambulatory BP monitoring were available for 292 patients. The prevalence rates of children with hypertension and/or those who were treated with antihypertensive drugs were 31%, 42%, and 35% during daytime, nighttime, or the entire 24-hour cycle, respectively. In addition, 52% of participants lacked a physiologic nocturnal BP dipping, and 18% had isolated nocturnal hypertension. Logistic regression analysis showed a significant association between a categorical cyst score that was calculated on the basis of the number of cysts >1 cm per kidney and daytime hypertension (odds ratio, 1.70; 95% confidence interval, 1.21 to 2.4; P=0.002), nighttime hypertension (odds ratio, 1.31; 95% confidence interval, 1.05 to 1.63; P=0.02), or 24-hour hypertension (odds ratio, 1.39; 95% confidence interval, 1.08 to 1.81; P=0.01). Kidney length, expressed as SD score, was also significantly associated with nighttime hypertension (odds ratio, 1.23; 95% confidence interval, 1.06 to 1.42; P=0.10).CONCLUSIONS: These data indicate high prevalence of hypertension in children with autosomal dominant polycystic kidney disease starting at young ages.

AB - BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitoring is the preferred method to diagnose hypertension in pediatrics, data in children with autosomal dominant polycystic kidney disease are limited.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our retrospective multicenter study was conducted to collect ambulatory BP monitoring recordings from patients with autosomal dominant polycystic kidney disease age <18 years old. Basic anthropometric parameters as well as data on kidney function, BP treatment, and kidney ultrasound were also collected.RESULTS: Data from 310 children with autosomal dominant polycystic kidney disease with a mean age of 11.5±4.1 years old were collected at 22 European centers. At the time when ambulatory BP monitoring was performed, 95% of children had normal kidney function. Reference data for ambulatory BP monitoring were available for 292 patients. The prevalence rates of children with hypertension and/or those who were treated with antihypertensive drugs were 31%, 42%, and 35% during daytime, nighttime, or the entire 24-hour cycle, respectively. In addition, 52% of participants lacked a physiologic nocturnal BP dipping, and 18% had isolated nocturnal hypertension. Logistic regression analysis showed a significant association between a categorical cyst score that was calculated on the basis of the number of cysts >1 cm per kidney and daytime hypertension (odds ratio, 1.70; 95% confidence interval, 1.21 to 2.4; P=0.002), nighttime hypertension (odds ratio, 1.31; 95% confidence interval, 1.05 to 1.63; P=0.02), or 24-hour hypertension (odds ratio, 1.39; 95% confidence interval, 1.08 to 1.81; P=0.01). Kidney length, expressed as SD score, was also significantly associated with nighttime hypertension (odds ratio, 1.23; 95% confidence interval, 1.06 to 1.42; P=0.10).CONCLUSIONS: These data indicate high prevalence of hypertension in children with autosomal dominant polycystic kidney disease starting at young ages.

U2 - 10.2215/CJN.11401017

DO - 10.2215/CJN.11401017

M3 - Article

C2 - 29674338

VL - 13

SP - 874

EP - 883

JO - Clinical journal of the American Society of Nephrology : CJASN

JF - Clinical journal of the American Society of Nephrology : CJASN

SN - 1555-9041

IS - 6

ER -