Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2871-2882 |
| Number of pages | 12 |
| Journal | Eur. J. Nucl. Med. Mol. Imaging |
| Volume | 48 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2021 |
Keywords
- 18F-FDG PET/CT
- Asymptomatic
- COVID-19
- Incidental findings
- Interstitial pneumonia
- SARS-CoV-2
- fluorodeoxyglucose f 18
- clinical trial
- diagnostic imaging
- human
- interstitial lung disease
- Italy
- multicenter study
- pandemic
- positron emission tomography-computed tomography
- prevalence
- retrospective study
- Fluorodeoxyglucose F18
- Humans
- Lung Diseases, Interstitial
- Pandemics
- Positron Emission Tomography Computed Tomography
- Prevalence
- Retrospective Studies
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Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study : European Journal of Nuclear Medicine and Molecular Imaging. / Albano, D.; Bertagna, F.; Alongi, P. et al.
In: Eur. J. Nucl. Med. Mol. Imaging, Vol. 48, No. 9, 2021, p. 2871-2882.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study
T2 - European Journal of Nuclear Medicine and Molecular Imaging
AU - Albano, D.
AU - Bertagna, F.
AU - Alongi, P.
AU - Baldari, S.
AU - Baldoncini, A.
AU - Bartolomei, M.
AU - Boccaletto, F.
AU - Boero, M.
AU - Borsatti, E.
AU - Bruno, A.
AU - Burroni, L.
AU - Capoccetti, F.
AU - Castellani, M.
AU - Cervino, A.R.
AU - Chierichetti, F.
AU - Ciarmiello, A.
AU - Corso, A.
AU - Cuocolo, A.
AU - De Rimini, M.L.
AU - Deandreis, D.
AU - Dottorini, M.E.
AU - Esposito, F.
AU - Farsad, M.
AU - Gasparini, M.
AU - Grana, C.M.
AU - Gregianin, M.
AU - Guerra, L.
AU - Loreti, F.
AU - Lupi, A.
AU - Martino, G.
AU - Milan, E.
AU - Modoni, S.
AU - Morbelli, S.
AU - Muni, A.
AU - Nicolai, E.
AU - Palumbo, B.
AU - Papa, S.
AU - Papaleo, A.
AU - Pellerito, R.
AU - Poti, C.
AU - Romano, P.
AU - Rossetti, C.
AU - Rossini, P.
AU - Rubini, G.
AU - Ruffini, L.
AU - Sacchetti, G.
AU - Savelli, G.
AU - Schiavariello, S.
AU - Sciagrà, R.
AU - Sciuto, R.
AU - Seregni, E.
AU - Sestini, S.
AU - Sicolo, M.
AU - Spanu, A.
AU - Storto, G.
AU - Balducci, M.T.
AU - Trifirò, G.
AU - Versari, A.
AU - Vignati, A.
AU - Volterrani, D.
AU - Calcagni, M.L.
AU - Marzola, M.C.
AU - Garufo, A.
AU - Evangelista, L.
AU - Maroldi, R.
AU - Schillaci, O.
AU - Giubbini, R.
AU - Bonacina, M.
AU - Laudicella, R.
AU - Spallino, M.
AU - Palucci, A.
AU - Cuzzocrea, M.
AU - Donner, M.
AU - Maurea, S.
AU - Ceci, F.
AU - Dei Rossi, F.
AU - Tranfaglia, B.
AU - Sartorello, A.
AU - Gandolfo, P.
AU - Buschiazzo, A.
AU - Scarale, A.
AU - Kirienko, M.
AU - Merenda, N.
AU - Nappi, A.G.
AU - Durmo, R.
AU - Vellani, C.
AU - Ceriani, V.
AU - (AIMN), On the behalf of Italian Association of Nuclear Medicine
N1 - Cited By :4 Export Date: 20 October 2021 CODEN: EJNMA Correspondence Address: Albano, D.; Nuclear Medicine, Italy; email: domenico.albano@unibs.it Chemicals/CAS: fluorodeoxyglucose f 18, 63503-12-8; Fluorodeoxyglucose F18 Funding details: Università degli Studi di Brescia References: Park, M., Thwaites, R.S., Openshaw, P.J.M., COVID-19: lessons from SARS and MERS (2020) Eur J Immunol, 50 (3), pp. 308-311. , COI: 1:CAS:528:DC%2BB3cXjslyltb8%3D; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , COI: 1:CAS:528:DC%2BB3cXhs1Kqu7c%3D; Lan, L., Xu, D., Ye, G., Positive RT-PCR test results in patients recovered from COVID-19 (2020) JAMA, , https://doi.org/10.1001/jama.2020.2783; Kanne, J.P., Little, B.P., Chung, J.H., Essentials for radiologists on COVID-19: an update radiology scientific expert panel (2020) Radiology, 295 (1), pp. 16-17; Shi, H., Han, X., Jiang, N., Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: A descriptive study (2020) Lancet Infect Dis, , https://doi.org/10.1016/S1473-3099(20)30086-4; Eyp, L., Ng, M.Y., Khong, P.L., COVID-19 pneumonia: What has CT taught us (2020) Lancet Infect Dis, , https://doi.org/10.1016/S1473-3099(20)30134-1; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 bovel coronavirus (2019-nCoV) (2020) Radiology, , https://doi.org/10.1148/radiol.2020200230; Fang, Y., Zhang, H., Xie, J., Sensitivity of chest CT for COVID-19: comparison to RT-PCR (2020) Radiology, 296, pp. E115-E117; Xie, X., Zhong, Z., Zhao, W., Chest CT for typical 2019-nCoV pneumonia: Relationship to negative RT-PCR testing (2020) Radiology, , https://doi.org/10.1148/radiol.2020200343; Albano, D., Bertagna, F., Bertoli, M., Incidental findings suggestive of COVID-19 in asymptomatic patients undergoing nuclear medicine procedures in a high-prevalence region (2020) J Nucl Med, 61, pp. 632-636. , COI: 1:CAS:528:DC%2BB3cXhvVOis7zM; Setti, L., Kirienko, M., Dalto, S.M., FDG-PET/CT findings highly suspicious for COVID-19 in an Italian case series of asymptomatic patients (2020) Eur J Nucl Med Mol Imaging, 47, pp. 1649-1656. , COI: 1:CAS:528:DC%2BB3cXotVCisLs%3D; Colandrea, M., Gilardi, L., Travaini, L.L., 18F-FDG PET/CT in asymptomatic patients with COVID-19: the submerged iceberg surfaces (2020) Jpn J Radiol, 38, pp. 1007-1011. , COI: 1:CAS:528:DC%2BB3cXht1GjsrbP; Scarlattei, M., Baldari, G., Silva, M., Unknown SARS-CoV-2 pneumonia detected by PET/CT in patients with cancer (2020) Tumori, 106, pp. 325-332. , COI: 1:CAS:528:DC%2BB3cXhsVahu7vM; Polverari, G., Arena, V., Ceci, F., 18 F-Fluorodeoxyglucose uptake in patient with asymptomatic severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019) referred to positron emission tomography/computed tomography for NSCLC restaging (2020) J Thoracic Oncol, 15, pp. 1078-1080. , COI: 1:CAS:528:DC%2BB3cXntFGhtLY%3D; Albano, D., Camoni, L., Rinaldi, R., 18F-FDG PET/CT metabolic behavior of COVID-19 pneumonia: a series of 4 patients with RT-PCR confirmation (2020) Clin Nucl Med, 45, pp. e378-e380; Maurea, S., Mainolfi, C.G., Bombace, C., FDG-PET/CT imaging during the Covid-19 emergency: a southern Italian perspective (2020) Eur J Nucl Med Mol Imaging, 47, pp. 2691-2697. , COI: 1:CAS:528:DC%2BB3cXht1Cqt7jM; Setti, L., Bonacina, M., Meroni, R., Increased incidence of interstitial pneumonia detected on [18F]-FDG-PET/CT in asymptomatic cancer patients during COVID-19 pandemic in Lombardy: A casualty or COVID-19 infection? (2020) Eur J Nucl Med Mol Imaging, , https://doi.org/10.1007/s00259-020-05027-y; Pallardy, A., Rousseau, C., Labbe, et al, Incidental findings suggestive of COVID-19 in asymptomatic cancer patients undergoing 18F-FDG PET/CT in a low prevalence region (2020) Eur J Nucl Med Mol Imaging, 28, pp. 1-6; Halsey, R., Priftakis, D., Mackenzie, S., COVID-19 in the act: Incidental18 F-FDG PET/CT findings in asymptomatic patients and those with symptoms not primarily correlated with COVID-19 during the United Kingdom coronavirus lockdown (2020) Eur J Nucl Med Mol Imaging, , https://doi.org/10.1007/s00259-020-04972-y; Boellaard, R., O'Doherty, M.J., Weber, W.A., FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 (2010) Eur J Nucl Med Mol Imaging, 37, pp. 181-200; Hani, C., Trieu, N.H., Saab, I., COVID-19 pneumonia: a review of typical CT findings and differential diagnosis (2020) Diagn Interv Imaging, 101, pp. 263-268. , COI: 1:STN:280:DC%2BB38zltlWisA%3D%3D; Ye, Z., Zhang, Y., Wang, Y., Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review (2020) Eur Radiol, 30, pp. 4381-4389. , COI: 1:CAS:528:DC%2BB3cXhtlekt7fK; Han, R., Huang, L., Jiang, H., Early clinical and CT manifestations of coronavirus disease 2019 (COVID-19) pneumonia (2020) AJR Am J Roentgenol, 215, pp. 338-343; Bao, C., Liu, X., Zhang, H., Coronavirus disease 2019 (COVID-19) CT findings: a systematic review and meta-analysis (2020) J Am Coll Radiol, 17, pp. 701-709; Treglia, G., The role of 18F-FDG PET for COVID-19 infection: myth versus reality (2020) Clin Transl Imaging, 8, pp. 125-126; Zhou, F., Yu, T., Du, R., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study (2020) Lancet, 395, pp. 1054-1062. , COI: 1:CAS:528:DC%2BB3cXkvVGktL8%3D; Tang, N., Li, D., Wang, X., Sun, Z., Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia (2020) J Thromb Haemost, 18, pp. 844-847. , COI: 1:CAS:528:DC%2BB3cXlvV2ns70%3D; McGonagle, D., Sharif, K., O'Regan, A., The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease (2020) Autoimmun Rev, 19, p. 102537. , COI: 1:CAS:528:DC%2BB3cXms1ylt78%3D; Annunziata, S., Delgado Bolton, R.C., Kamani, C.E., Role of 2-[18F]FDG as a radiopharmaceutical for PET/CT in patients with COVID-19: a systematic review (2020) Pharmaceuticals (Basel), 13; Annunziata, S., Bauckneht, M., Albano, D., Impact of the COVID-19 pandemic in nuclear medicine departments: preliminary report of the first international survey (2020) Eur J Nucl Med Mol Imaging, 47, pp. 2090-2099. , COI: 1:CAS:528:DC%2BB3cXhtVGnu7vL; Ai, T., Yang, Z., Hou, H., Correlation of chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases (2020) Radiology, 296, pp. E32-E49
PY - 2021
Y1 - 2021
N2 - Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management. © 2021, The Author(s).
AB - Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management. © 2021, The Author(s).
KW - 18F-FDG PET/CT
KW - Asymptomatic
KW - COVID-19
KW - Incidental findings
KW - Interstitial pneumonia
KW - SARS-CoV-2
KW - fluorodeoxyglucose f 18
KW - clinical trial
KW - diagnostic imaging
KW - human
KW - interstitial lung disease
KW - Italy
KW - multicenter study
KW - pandemic
KW - positron emission tomography-computed tomography
KW - prevalence
KW - retrospective study
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Lung Diseases, Interstitial
KW - Pandemics
KW - Positron Emission Tomography Computed Tomography
KW - Prevalence
KW - Retrospective Studies
U2 - 10.1007/s00259-021-05219-0
DO - 10.1007/s00259-021-05219-0
M3 - Article
VL - 48
SP - 2871
EP - 2882
JO - Eur. J. Nucl. Med. Mol. Imaging
JF - Eur. J. Nucl. Med. Mol. Imaging
SN - 1619-7070
IS - 9
ER -